Dapsone

Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.wikipedia
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Clofazimine

Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy.

Leprosy

leperlepersleper hospital
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
Treatment for paucibacillary leprosy is with the medications dapsone and rifampicin for six months.

Pyrimethamine

It is unclear if the combination with pyrimethamine is useful in the prevention of malaria.
It is also used with dapsone as a second-line option to prevent Pneumocystis jiroveci pneumonia in people with HIV/AIDS.

Rifampicin

rifampin
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
With multidrug therapy used as the standard treatment of Hansen's disease, rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance.

Trimethoprim

triomethoprim
It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole.
With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.

WHO Model List of Essential Medicines

World Health Organization's List of Essential MedicinesList of Essential MedicinesModel List of Essential Medicines
It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.
Dapsone

Drug reaction with eosinophilia and systemic symptoms

DRESS syndromedrug induced hypersensitivity syndromeDrug reaction with eosinophilia and systemic symptoms aka DRESS
The reaction always involves a rash, may also include fever, jaundice, and eosinophilia, and is likely to be one manifestation of the SCARs reaction viz., the DRESS syndrome (see above).
This is evident in the most commonly cited drugs that cause the DRESS syndrome viz., allopurinol, sulfasalazine, and minocycline, as well as in prominent but less commonly cited causes of the disorder such as strontium ranelate, leflunomide, dapsone, and nonsteroidal anti-inflammatory drugs (diclofenac, celecoxib, ibuprofen, and phenylbutazone).

Glucose-6-phosphate dehydrogenase deficiency

favismG6PD deficiencyG6PD
Severe side effects may include a decrease in blood cells, red blood cell breakdown especially in those with glucose-6-phosphate dehydrogenase deficiency (G-6-PD), or hypersensitivity.
Sulfonamides (such as sulfanilamide, sulfamethoxazole, and mafenide), thiazolesulfone, methylene blue, and naphthalene should also be avoided by people with G6PD deficiency as they antagonize folate synthesis, as should certain analgesics (such as phenazopyridine and acetanilide) and a few non-sulfa antibiotics (nalidixic acid, nitrofurantoin, isoniazid, dapsone, and furazolidone).

Severe cutaneous adverse reactions

It is a form of severe cutaneous adverse reactions (SCARs) in which a SCARs disorder, primarily the DRESS syndrome or a DRESS syndrome-like reaction occurs.
Allopurinol and sulfasalazine account for almost 66% of DRESS syndrome cases with minocycline being the third most common cause of the disorder; Strontium ranelate, leflunomide, dapsone, and nonsteroidal anti-inflammatory drugs (diclofenac, celecoxib, ibuprofen, and phenylbutazone) are less common causes of the disorder.

Methemoglobinemia

methaemoglobinaemiaacquired methaemoglobinaemiaelevated methemoglobin
The most prominent side-effects of this drug are dose-related hemolysis (which may lead to hemolytic anemia) and methemoglobinemia.
Classical drug causes of methemoglobinaemia include various antibiotics (trimethoprim, sulfonamides, and dapsone ), local anesthetics (especially articaine, benzocaine, prilocaine, and lidocaine ), and aniline dyes, metoclopramide, rasburicase, chlorates, and bromates.

Acne

acne vulgariscystic acneblemishes
Additionally, it has been used for acne, dermatitis herpetiformis, and various other skin conditions.
Dapsone is not a first-line topical antibiotic due to higher cost and lack of clear superiority over other antibiotics.

Pneumocystis pneumonia

Pneumocystis'' pneumoniapneumocystis carinii pneumoniaPCP
It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function.
Other medications that are used, alone or in combination, include pentamidine, trimetrexate, dapsone, atovaquone, primaquine, pafuramidine maleate (under investigation), and clindamycin.

CYP3A4

cytochrome P450 3A43A4cytochrome P450-3A4
Dapsone is metabolized by the Cytochrome P450 system, specifically isozymes CYP2D6, CYP2B6, CYP3A4, and CYP2C19.

Sulfone

sulfonesselenonesulphone
It is of the sulfone class.
Examples of sulfones in pharmacology include dapsone, a drug formerly used as an antibiotic to treat leprosy, dermatitis herpetiformis, tuberculosis, or pneumocystis pneumonia (PCP).

Dermatitis herpetiformis

Duhring's diseaseskin condition
Additionally, it has been used for acne, dermatitis herpetiformis, and various other skin conditions.
Dapsone is an effective initial treatment in most people.

Brown recluse spider

brown reclusebrown reclusesL. reclusa
Dapsone may be used to treat brown recluse spider bites that become necrotic.
Many other therapies have been used with varying degrees of success, including hyperbaric oxygen, dapsone, antihistamines (e.g., cyproheptadine), antibiotics, dextran, glucocorticoids, vasodilators, heparin, nitroglycerin, electric shock, curettage, surgical excision, and antivenom.

Chlorproguanil/dapsone

This led GlaxoSmithKline to develop Lapdap, a combination drug consisting of chlorproguanil and dapsone.
Chlorproguanil/dapsone (sold commercially as Lapdap) was a fixed dose antimalarial combination containing chlorproguanil and dapsone, which act synergystically against malaria.

History of leprosy

Later, Indian scientist Shantaram Yawalkar and his colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance.

Leprostatic agent

Antileproticantileprotic drugleprostatic agents
dapsone

Leukemoid reaction

leukocyte liposomal releaseleukocytic reaction
Use of dapsone

The Leprosy Mission

IndiaLeprosy MissionAmerican Leprosy Mission
1940s-50s – The first effective cure for leprosy, Dapsone, is introduced.

Promin

glucosulfone
It is broken down in the body to dapsone, which is the therapeutic form.

Iisalmi

IdensalmiIisalmen
Normet, engineers and manufacturers of mechanised equipment for underground rock-mining and tunnelling, also has its factory and headquarters in Iisalmi.