Dermatomyositis

Gottron's papulesAnti-Jo1dermatomyisitisjuvenile dermatomyositis
Dermatomyositis (DM) is a long-term inflammatory disorder which affects muscles.wikipedia
179 Related Articles

Inflammatory myopathy

inflammatory myopathiesidiopathic inflammatory myopathiesinflammatory muscle disease
It is a type of inflammatory myopathy. It has also been classified as an idiopathic inflammatory myopathy along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis, and sporadic inclusion body myositis.
The main classes of idiopathic inflammatory myopathy are polymyositis (PM), dermatomyositis (DM), and inclusion-body myositis (IBM).

Electromyography

EMGelectromyogramelectromyographic
Diagnosis is typically based on some combination of symptoms, blood tests, electromyography, and muscle biopsies.

Autoimmunity

autoimmuneautoantigenauto-immune
The cause is unknown, but it may result from an initial viral infection or cancer, either of which could raise an autoimmune response. Between 7 and 30% of dermatomyositis arise from cancer, probably as an autoimmune response.
Prominent examples include celiac disease, diabetes mellitus type 1, Henloch Scholein Pupura (HSP) sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), ankylosing spondylitis, polymyositis (PM), dermatomyositis (DM) and multiple sclerosis (MS).

Calcinosis

c'''alcinosisCalcinosis universaliscalcium deposit
Complications may include calcium deposits in muscles or skin.

Polymyositis

The diagnosis of dermatomyositis is based on five criteria which are also used to differentially diagnose with respect to polymyositis:
Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis.

Heliotrope (color)

heliotrope
One form the rashes take is called "heliotrope" (a purplish color) or lilac, but may also be red.

Immunoglobulin therapy

intravenous immunoglobulinIVIGintravenous immunoglobulins
Intravenous immunoglobulin may also improve outcomes.
Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as dermatomyositis in an attempt to decrease the severity of symptoms.

Inflammation

inflammatoryinflammatory responseinflamed
Dermatomyositis (DM) is a long-term inflammatory disorder which affects muscles.
They may occur in conjunction with other immune disorders, such as systemic sclerosis, and include dermatomyositis, polymyositis, and inclusion body myositis.

Paraneoplastic syndrome

paraneoplasticparaneoplastic syndromesparaneoplastic disease
Between 7 and 30% of dermatomyositis arise from cancer, probably as an autoimmune response.
The following diseases manifest by means of mucocutaneous dysfunction: acanthosis nigricans, dermatomyositis, Leser-Trélat sign, necrolytic migratory erythema, Sweet's syndrome, Florid cutaneous papillomatosis, pyoderma gangrenosum, and acquired generalized hypertrichosis.

Anti-nuclear antibody

anti-nuclear antibodiesANAantinuclear antibodies
Dermatomyositis is associated with autoantibodies, especially antinuclear antibodies (ANA).
This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren's syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.

Autoantibody

autoantibodiesauto-antibodiesanti-drug antibodies
Dermatomyositis is associated with autoantibodies, especially antinuclear antibodies (ANA).

Muscle biopsy

muscle biopsiesSkeletal muscle biopsy
Diagnosis is typically based on some combination of symptoms, blood tests, electromyography, and muscle biopsies.

Juvenile dermatomyositis

Childhood dermatomyositis
There is a form of this disorder that strikes children, known as juvenile dermatomyositis (JDM).
It manifests itself in children; it is the pediatric counterpart of dermatomyositis.

Myositis

muscle inflammationmyosistismyositides
It has also been classified as an idiopathic inflammatory myopathy along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis, and sporadic inclusion body myositis.

Corticosteroid

corticosteroidssteroidssteroid
Medications in the corticosteroids family are typically used with other agents like methotrexate or azathioprine recommended if steroids are not working well.

Histidine—tRNA ligase

histidine-tRNA ligasehistidyl-tRNA synthetasehistidyl tRNA synthetase
Around 80% of people with DM test positive for ANA and around 30% of people have myositis-specific autoantibodies which include antibodies to aminoacyl-tRNA synthetases (anti-synthetase antibodies), including antibodies against histidine—tRNA ligase (also called Jo-1); antibodies to signal recognition particle (SRP); and anti-Mi-2 antibodies.
* Anti-Jo1

Aspartate transaminase

aspartate aminotransferaseASTserum glutamic oxaloacetic transaminase
For example, muscle inflammation due to dermatomyositis may cause AST>ALT.

Inclusion body myositis

myositis, inclusion bodyinclusion-body myositis
It has also been classified as an idiopathic inflammatory myopathy along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis, and sporadic inclusion body myositis.
They are dermatomyositis (DM) and polymyositis (PM) and all three illnesses were called idiopathic (of unknown origin) myositis or inflammatory myopathies.

Maria Callas

CallasMaria KallasMaria Meneghini Callas
According to their findings, presented at the University of Bologna in 2010, Callas had dermatomyositis, a rare, connective tissue disease that causes a failure of the muscles and ligaments, including the larynx.

Rob Buckman

Robert BuckmanBuckman, Robert
In 1979, Buckman was diagnosed with dermatomyositis, an autoimmune disease which seriously affected his ability to work and was nearly fatal.

Ricky Bell (running back)

Ricky BellBell, Ricky
Bell died at age 29 of heart failure caused by the disease of dermatomyositis.

Laurence Olivier

Lord OlivierSir Laurence OlivierOlivier
Olivier spent the last 15 years of his life in securing his finances and dealing with deteriorating health, which included thrombosis and dermatomyositis, a degenerative muscle disorder.

Muscle

musclesmuscularmusculature
Dermatomyositis (DM) is a long-term inflammatory disorder which affects muscles.