A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).
Cell adhesion in desmosomes

Desmin has been shown to interact with desmoplakin and αB-crystallin.

- Desmin

In cardiomyocytes, desmoplakin forms desmosomal plaques with the intermediate filament desmin, whereas in endothelial cells cytokeratin type intermediate filaments are recruited, and vimentin in arachnoid and follicular dendritic cell types.

- Desmoplakin
A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

1 related topic

Alpha

Structure of lamin a/c globular domain

Intermediate filament

Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates.

Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates.

Structure of lamin a/c globular domain
Structure of intermediate filament
Human vimentin coil 2b fragment (cys2)
Keratin intermediate filaments (stained red) around epithelial cells
Vimentin fibers in fibroblasts

Desmin IFs are structural components of the sarcomeres in muscle cells and connect different cell organells like the desmosomes with the cytoskeleton.

Keratin filaments in epithelial cells link to desmosomes (desmosomes connect the cytoskeleton together) through plakoglobin, desmoplakin, desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells.