Desmoplakin
Protein in humans that is encoded by the DSP gene.
- Desmoplakin21 related topics
Desmosome
Cell structure specialized for cell-to-cell adhesion.
The outer dense plaque, which is about 15–20 nm in length, contains the intracellular ends of desmocollin and desmoglein, the N-terminus side of desmoplakin, and the armadillo family of mediatory proteins plakoglobin and plakophilin.
Palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Type 2: : DSP
Desmin
Protein that in humans is encoded by the DES gene.
Desmin has been shown to interact with desmoplakin and αB-crystallin.
Intermediate filament
Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates.
Keratin filaments in epithelial cells link to desmosomes (desmosomes connect the cytoskeleton together) through plakoglobin, desmoplakin, desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells.
Plakoglobin
Protein that in humans is encoded by the JUP gene.
Studies investigating the role of plakoglobin in disease pathology have found that suppression of desmoplakin expression by siRNA led to the nuclear localization of plakoglobin, resulting in a reduction in Wnt signaling via Tcf/Lef1 and ensued pathogenesis of ARVC.
Paraneoplastic pemphigus
Autoimmune disorder stemming from an underlying tumor.
Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, desmoplakin 1, desmoplakin 2, and bullous pemphigoid antigen I.
Keratin 1
Member of the keratin family.
Keratin 1 has been shown to interact with Desmoplakin and PRKCE.
Plakophilin-2
Protein that in humans is encoded by the PKP2 gene.
Plakophilin 2 localizes to cell desmosomes and nuclei and binds plakoglobin, desmoplakin, and the desmosomal cadherins via N-terminal head domain.
Plakophilin-1
Protein that in humans is encoded by the PKP1 gene.
PKP1 has been shown to interact with Desmoplakin.