Cell adhesion in desmosomes
Young woman with malar rash, typically found in systemic lupus erythematosus (SLE)

Mutations in desmoplakin have been shown to play a role in dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, striate palmoplantar keratoderma, Carvajal syndrome and paraneoplastic pemphigus.

- Desmoplakin

Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, desmoplakin 1, desmoplakin 2, and bullous pemphigoid antigen I.

- Paraneoplastic pemphigus
Cell adhesion in desmosomes

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