Diabetic foot ulcer

foot ulcerfoot ulcersdiabetes foot ulcersDiabetic Foot sepsisdiabetic foot woundsneuropathic ulcer
Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot.wikipedia
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Diabetes mellitus

diabetesdiabeticdiabetics
Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process.
Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes.

Total contact casting

Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting.
Total contact casting (TCC) is a specially designed cast designed to take weight off of the foot (off-loading) in patients with diabetic foot ulcers (DFUs).

Diabetic foot

diabetic foot syndromeProblem Woundsdiabetes-related foot infections
Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot.
Presence of several characteristic diabetic foot pathologies such as infection, diabetic foot ulcer and neuropathic osteoarthropathy is called diabetic foot syndrome.

Complications of diabetes mellitus

diabetes complicationsdiabetic complicationscomplication of diabetes mellitus
Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot.
Diabetic foot, often due to a combination of sensory neuropathy (numbness or insensitivity) and vascular damage, increases rates of skin ulcers (diabetic foot ulcers) and infection and, in serious cases, necrosis and gangrene. It is why it takes longer for diabetics to heal from leg and foot wounds and why diabetics are prone to leg and foot infections. In the developed world is the most common cause of non-traumatic adult amputation, usually of toes and or feet.

Dressing (medical)

dressingdressingswound dressing
Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting.
However, it is not used in wound with high discharge and neuropathic ulcers.

Ulcer (dermatology)

ulcerulcersulceration
Blisters and sores appear on numb areas of the feet and legs such as metatarso-phalangeal joints, heel region and as a result pressure or injury goes unnoticed and eventually become portal of entry for bacteria and infection.
Neuropathic ulcer

Diabetic sock

Steps to prevent diabetic foot ulcers include frequent review by a foot specialist, good foot hygiene, diabetic socks and shoes, as well as avoiding injury.
Diabetes raises the blood sugar level, which can increase the risk of foot ulcers.

Alginate dressing

Dressings and creams containing silver have not been properly studied nor have alginate dressings.
There is no evidence of superior effectiveness in those with diabetic foot ulcers.

Granulation tissue

scar tissuegranulationproud flesh
Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

Wound

lacerationlacerationswounds
Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

Ultimate tensile strength

tensile strengthtensileultimate strength
Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

Blood sugar level

blood sugarblood glucoseblood glucose level
Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting.

Debridement

debridedebrideddebriding
Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting.

Hyperbaric medicine

hyperbaric oxygen therapyhyperbarichyperbaric oxygen
Hyperbaric oxygen therapy may also help but is expensive.

Diabetic neuropathy

neuropathydiabetic neuropathiesdiabetes
Risk factors implicated in the development of diabetic foot ulcers are infection, older age, diabetic neuropathy, peripheral vascular disease, cigarette smoking, poor glycemic control, previous foot ulcerations or amputations, and ischemia of small and large blood vessels.

Edema

dropsyoedemaswelling
Prior history of foot disease, foot deformities that produce abnormally high forces of pressure, renal failure, oedema, impaired ability to look after personal care (e.g. visual impairment) are further risk factors for diabetic foot ulcer.

Blister

blistersbullaevesication
Blisters and sores appear on numb areas of the feet and legs such as metatarso-phalangeal joints, heel region and as a result pressure or injury goes unnoticed and eventually become portal of entry for bacteria and infection.

Bacteria

bacteriumbacterialeubacteria
Blisters and sores appear on numb areas of the feet and legs such as metatarso-phalangeal joints, heel region and as a result pressure or injury goes unnoticed and eventually become portal of entry for bacteria and infection.

Infection

infectious diseaseinfectious diseasesinfectious
Blisters and sores appear on numb areas of the feet and legs such as metatarso-phalangeal joints, heel region and as a result pressure or injury goes unnoticed and eventually become portal of entry for bacteria and infection.

Extracellular matrix

ECMmatrixextracellular matrices
A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. Through the interaction of cell with its extracellular matrix (transmitted through the anchoring molecules classed as integrins) there forms a continuous association between cell interior, cell membrane and extracellular matrix components that help drive various cellular events in a regulated fashion.

Dermis

dermaldermal papillaepapillary dermis
The dermis lies below the epidermis, and these two layers are collectively known as the skin.

Epidermis

epidermalrete ridgesepidermal cells
The dermis lies below the epidermis, and these two layers are collectively known as the skin.

Skin

cutaneousskin cellanimal skin
The dermis lies below the epidermis, and these two layers are collectively known as the skin.

Connective tissue

fibrous tissuefibrous connective tissueconnective
The specific species of ECM of connective tissues often differ chemically, but collagen generally forms the bulk of the structure.

Integrin

integrinsintegrin receptorintegrin alpha1
Through the interaction of cell with its extracellular matrix (transmitted through the anchoring molecules classed as integrins) there forms a continuous association between cell interior, cell membrane and extracellular matrix components that help drive various cellular events in a regulated fashion.