A report on Malaria and Doxycycline

Malaria parasite connecting to a red blood cell
Generic 100 mg doxycycline capsules
Main symptoms of malaria
Doxycycline package
The life cycle of malaria parasites. Sporozoites are introduced by a mosquito bite. They migrate to the liver, where they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Tet-ON inducible shRNA system
Micrograph of a placenta from a stillbirth due to maternal malaria. H&E stain. Red blood cells are anuclear; blue/black staining in bright red structures (red blood cells) indicate foreign nuclei from the parasites.
Electron micrograph of a Plasmodium falciparum-infected red blood cell (center), illustrating adhesion protein "knobs"
The blood film is the gold standard for malaria diagnosis.
Ring-forms and gametocytes of Plasmodium falciparum in human blood
An Anopheles stephensi mosquito shortly after obtaining blood from a human (the droplet of blood is expelled as a surplus). This mosquito is a vector of malaria, and mosquito control is an effective way of reducing its incidence.
Man spraying kerosene oil in standing water, Panama Canal Zone, 1912
Walls where indoor residual spraying of DDT has been applied. The mosquitoes remain on the wall until they fall down dead on the floor.
A mosquito net in use.
An advertisement for quinine as a malaria treatment from 1927.
Deaths due to malaria per million persons in 2012
Past and current malaria prevalence in 2009
Ancient malaria oocysts preserved in Dominican amber
British doctor Ronald Ross received the Nobel Prize for Physiology or Medicine in 1902 for his work on malaria.
Chinese medical researcher Tu Youyou received the Nobel Prize for Physiology or Medicine in 2015 for her work on the antimalarial drug artemisinin.
Artemisia annua, source of the antimalarial drug artemisinin
U.S. Marines with malaria in a field hospital on Guadalcanal, October 1942
Members of the Malaria Commission of the League of Nations collecting larvae on the Danube delta, 1929
1962 Pakistani postage stamp promoting malaria eradication program
Malaria clinic in Tanzania
Child with malaria in Ethiopia
World War II poster
Disability-adjusted life year for malaria per 100,000 inhabitants in 2004 no data <10 0–100 100–500 500–1000 1000–1500 1500–2000 2000–2500 2500–2750 2750–3000 3000–3250 3250–3500 ≥3500

It is also used to prevent malaria in combination with quinine.

- Doxycycline

Quinine, along with doxycycline, may be used if artemisinin is not available.

- Malaria
Malaria parasite connecting to a red blood cell

2 related topics with Alpha

Overall

Plasmodium falciparum

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Laveran's drawing of various stages of P. falciparum as seen on fresh blood (1880).
Blood smear from a P. falciparum culture (K1 strain - asexual forms) - several red blood cells have ring stages inside them. Close to the center is a schizont and on the left a trophozoite.
Ring forms in red blood cells (Giemsa stain)
Life cycle of Plasmodium

Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans.

As second-line antimalarial treatment, when initial treatment does not work, an alternative ACT known to be effective in the region is recommended, such as artesunate plus tetracycline or doxycycline or clindamycin, and quinine plus tetracycline or doxycycline or clindamycin.

Electron micrograph of Treponema pallidum

Syphilis

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Sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.

Sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.

Electron micrograph of Treponema pallidum
Primary chancre of syphilis at the site of infection on the penis
Typical presentation of secondary syphilis with a rash on the palms of the hands
Reddish papules and nodules over much of the body due to secondary syphilis
Model of a head of a person with tertiary (gummatous) syphilis, Musée de l'Homme, Paris
Histopathology of Treponema pallidum spirochetes using a modified Steiner silver stain
This poster acknowledges the social stigma of syphilis, while urging those who possibly have the disease to be tested (circa 1936).
Micrograph of secondary syphilis skin lesions. (A/B) H&E stain of SS lesions. (C/D) IHC staining reveals abundant spirochetes embedded within a mixed cellular inflammatory infiltrate (shown in the red box) in the papillary dermis. The blue arrow points to a tissue histiocyte and the read arrows to two dermal lymphocytes.
Portrait of Mr. J. Kay, affected with what is now believed to have been congenital syphilis c. 1820
Jarisch–Herxheimer reaction in a person with syphilis and human immunodeficiency virus
Syphilis deaths per million persons in 2012
Portrait of Gerard de Lairesse by Rembrandt van Rijn, circa 1665–67, oil on canvas. De Lairesse, himself a painter and art theorist, had congenital syphilis that deformed his face and eventually blinded him.
An early medical illustration of people with syphilis, Vienna, 1498
A Work Projects Administration poster about syphilis c. 1940
Preparation and Use of Guayaco for Treating Syphilis, after Stradanus, 1590

In those who have a severe penicillin allergy, doxycycline or tetracycline may be used.

False positives can also occur with lymphoma, tuberculosis, malaria, endocarditis, connective tissue disease, and pregnancy.