A report on Fibromyalgia and Duloxetine

The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia
Cymbalta (duloxetine) 60mg
A woman feeling stress
The location of the nine paired tender points that comprise the 1990 American College of Rheumatology criteria for fibromyalgia
Widespread pain index (WPI) areas
Stress and trauma are strongly linked to fibromyalgia

Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization.

- Duloxetine

The medications duloxetine, milnacipran, or pregabalin have been approved by the US Food and Drug Administration (FDA) for the management of fibromyalgia.

- Fibromyalgia
The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia

2 related topics with Alpha

Overall
Duloxetine, an example of an SNRI.

Serotonin–norepinephrine reuptake inhibitor

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Duloxetine, an example of an SNRI.
Timeline of approved SNRIs.
Timeline of development of antidepressant agents.
Inhibiting the reuptake transport protein results in increased concentrations of serotonin and norepinephrine in the synaptic clefts, leading to improvement of depression symptoms.
Aryloxypropanamine scaffold and agents containing it.
Cycloalkanol ethylamine scaffold and agents containing it.
Structure of milnacipran.

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs used to treat major depressive disorder (MDD), anxiety disorders, obsessive–compulsive disorder (OCD), social phobia, attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

The half-life of duloxetine is about 12 hours (range: 8–17 hours), and steady-state is achieved after about 3 days.

Gate control theory of pain

Neuropathic pain

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Pain caused by damage or disease affecting the somatosensory system.

Pain caused by damage or disease affecting the somatosensory system.

Gate control theory of pain
Microglia (identified by alpha-coronin1a), and neurons in culture. Microglia are proposed to release molecules that alter the excitability of neurons.

Gabapentin may reduce symptoms associated with neuropathic pain or fibromyalgia in some people.

Dual serotonin-norepinephrine reuptake inhibitors in particular duloxetine, as well as tricyclic antidepressants in particular amitriptyline, and nortriptyline are considered first-line medications for this condition.