EPSP synthase

5-enolpyruvylshikimate-3-phosphate synthase3-phosphoshikimate 1-carboxyvinyltransferase5-enolpyruvylshikimate-3-phosphate5-''enol''pyruvylshikimate-3-phosphate synthase5-O-(1-carboxyvinyl)-3-phosphoshikimateEnolpyruvylshikimate 3-phosphate synthase enzyme
5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.wikipedia
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Glyphosate

Roundupglycosphateglyphosates
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase.

Shikimic acid

shikimateshikimate pathwayshikimic
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate. EPSP synthase participates in the biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan via the shikimate pathway in bacteria, fungi, and plants.
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Herbicide

herbicidesherbicidalweed killer
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
EPSPS inhibitors: Enolpyruvylshikimate 3-phosphate synthase enzyme (EPSPS) is used in the synthesis of the amino acids tryptophan, phenylalanine and tyrosine. They affect grasses and dicots alike. Glyphosate (Roundup) is a systemic EPSPS inhibitor inactivated by soil contact.

Genetically modified crops

genetically modifiedtransgenic cropsgenetically modified crop
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
More specifically, glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).

Shikimate pathway

shikimic acid pathwaypathwayShikimate acid pathway
Glyphosate is a competitive inhibitor of PEP, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway.
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Enzyme

enzymologyenzymesenzymatic
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate. 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.

Microorganism

microorganismsmicrobemicrobes
5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.

Substrate (chemistry)

substratessubstrateenzyme substrate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Phosphoenolpyruvic acid

phosphoenolpyruvatePEPphosphoenol pyruvate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Product (chemistry)

productsproductchemical products
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Phosphate

phosphatesphosphate groupinorganic phosphate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Biological target

drug targettargetbiomolecular target
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.

Transferase

transferasesformyltransferasecatalyzes the transfer
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

Aryl

arylationaryl groupbiaryl
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

Alkyl

alkyl groupalkyl groupsheptyl
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

Methyl group

methylCH 3 Me
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

List of enzymes

systematic nameclassified
The systematic name of this enzyme class is phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase. Other names in common use include:

Aromaticity

aromaticaromatic compoundaromatic ring
EPSP synthase participates in the biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan via the shikimate pathway in bacteria, fungi, and plants.

Phenylalanine

Phephenylalanine metabolism L -phenylalanine
EPSP synthase participates in the biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan via the shikimate pathway in bacteria, fungi, and plants.

Tyrosine

Tyrtyrosine metabolismphosphotyrosine
EPSP synthase participates in the biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan via the shikimate pathway in bacteria, fungi, and plants.

Tryptophan

Trptryptophan metabolism L -tryptophan
EPSP synthase participates in the biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan via the shikimate pathway in bacteria, fungi, and plants.

Gut flora

gut microbiotaintestinal floragut bacteria
Gut flora of some animals contain EPSPS.

Competitive inhibition

competitive inhibitorcompetitivecompetitive inhibitors
Glyphosate is a competitive inhibitor of PEP, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway.