EPSP synthase

5-enolpyruvylshikimate-3-phosphate synthase3-phosphoshikimate 1-carboxyvinyltransferase5-enolpyruvylshikimate-3-phosphate5-''enol''pyruvylshikimate-3-phosphate synthase5-O-(1-carboxyvinyl)-3-phosphoshikimateEnolpyruvylshikimate 3-phosphate synthase enzyme
5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.wikipedia
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Glyphosate

Roundupglycosphateglyphosates
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase.

Herbicide

herbicidesherbicidalweed killer
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
EPSPS inhibitors: Enolpyruvylshikimate 3-phosphate synthase enzyme (EPSPS) is used in the synthesis of the amino acids tryptophan, phenylalanine and tyrosine. They affect grasses and dicots alike. Glyphosate (Roundup) is a systemic EPSPS inhibitor inactivated by soil contact.

Shikimic acid

shikimateshikimate pathwayshikimic
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Genetically modified crops

genetically modifiedtransgenic cropsgenetically modified crop
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.
More specifically, glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).

Shikimate pathway

shikimic acid pathwaypathwayShikimate acid pathway
Glyphosate is a competitive inhibitor of PEP, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway.
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Chorismate synthase

Hence, this enzyme has one substrate, 5-O-(1-carboxyvinyl)-3-phosphoshikimate, and two products, chorismate and phosphate.

Genetically modified canola

Canola
One is a gene derived from the common soil bacterium Agrobacterium strain CP4, that encodes for the EPSPS enzyme.

Genetically modified soybean

soybeanRoundup Ready soybeanglyphosate-resistant soybean
Plants and microorganisms make these amino acids with an enzyme that only plants and lower organisms have, called 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).

Roundup Ready

herbicide-resistant crop plants
Some microorganisms have a version of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS: EC 2.5.1.19, 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthetase; phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase) that is resistant to glyphosate inhibition.

Shikimate kinase

The four enzymes that precede shikimate kinase in the pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, and shikimate dehydrogenase, and the two that follow it are EPSP synthase and chorismate synthase.

Enzyme inhibitor

inhibitorinhibitioninhibitors
The herbicide glyphosate is an inhibitor of 3-phosphoshikimate 1-carboxyvinyltransferase, other herbicides, such as the sulfonylureas inhibit the enzyme acetolactate synthase.

Enzyme

enzymologyenzymesenzymatic
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate. 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.

Microorganism

microorganismsmicrobemicrobes
5-enolpyruvylshikimate-3-phosphate (EPSP) synthase is an enzyme produced by plants and microorganisms.

Substrate (chemistry)

substratessubstrateenzyme substrate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Phosphoenolpyruvic acid

phosphoenolpyruvatePEPphosphoenol pyruvate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Product (chemistry)

productsproductchemical products
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Phosphate

phosphatesphosphate groupinorganic phosphate
Thus, the two substrates of this enzyme are phosphoenolpyruvate (PEP) and 3-phospho-shikimate, whereas its two products are phosphate and 5-enolpyruvylshikimate-3-phosphate.

Biological target

drug targettargetbiomolecular target
It is the biological target of the herbicide glyphosate, and a glyphosate-resistant version of this gene has been used in genetically modified crops.

Transferase

transferasesformyltransferasecatalyzes the transfer
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

Aryl

arylationaryl groupbiaryl
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

Alkyl

alkyl groupalkyl groupsheptyl
The enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.