Elastin

tropoelastinELNelasticelastin-bindingELN (gene)
Elastin is a key protein of the extracellular matrix.wikipedia
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Extracellular matrix

ECMmatrixextracellular matrices
Elastin is a key protein of the extracellular matrix.
Elastins, in contrast to collagens, give elasticity to tissues, allowing them to stretch when needed and then return to their original state.

Alpha-1 antitrypsin

alpha 1-antitrypsinα 1 -antitrypsinα1-antitrypsin
Other associated defects in elastin include Marfan syndrome, emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis, Buschke-Ollendorff syndrome, Menkes syndrome, pseudoxanthoma elasticum, and Williams syndrome.
When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil elastase is excessively free to break down elastin, degrading the elasticity of the lungs, which results in respiratory complications, such as chronic obstructive pulmonary disease, in adults.

Elastic fiber

elastic fiberselastic tissueelastic
The ELN gene encodes a protein that is one of the two components of elastic fibers. Elastic fiber in the body is a mixture of amorphous elastin and fibrous fibrillin.
Elastic fibers (or yellow fibers) are bundles of proteins (elastin) found in extracellular matrix of connective tissue and produced by fibroblasts and smooth muscle cells in arteries.

Protein

proteinsproteinaceousstructural proteins
Elastin is a key protein of the extracellular matrix.
Most structural proteins are fibrous proteins; for example, collagen and elastin are critical components of connective tissue such as cartilage, and keratin is found in hard or filamentous structures such as hair, nails, feathers, hooves, and some animal shells.

Connective tissue

fibrous tissuefibrous connective tissueconnective
It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting.
Elastic fibers, made from elastin and fibrillin, also provide resistance to stretch forces.

Cutis laxa

Cutis laxa seniliscutis laxa syndromeCutis laxa, dominant type
Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and the autosomal dominant cutis laxa.
Cutis laxa is associated with deficient or absent elastin fibers in the extracellular matrix.

Atherosclerosis

atheroscleroticatherogenesisatherosclerotic plaques
Other associated defects in elastin include Marfan syndrome, emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis, Buschke-Ollendorff syndrome, Menkes syndrome, pseudoxanthoma elasticum, and Williams syndrome.
The bulk of these lesions is made of excess fat, collagen, and elastin.

Artery

arteriesarterialarterial system
Elastin serves an important function in arteries as a medium for pressure wave propagation to help blood flow and is particularly abundant in large elastic blood vessels such as the aorta.
This layer is mainly made up of endothelial cells (and a supporting layer of elastin rich collagen in elastic arteries).

Fibrillin

FBN2fibrillin-1FBN3
Elastic fiber in the body is a mixture of amorphous elastin and fibrous fibrillin.
for deposition of elastin.

Lung

lungspulmonaryright lung
Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder.
Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres.

Pseudoxanthoma elasticum

PXE
Other associated defects in elastin include Marfan syndrome, emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis, Buschke-Ollendorff syndrome, Menkes syndrome, pseudoxanthoma elasticum, and Williams syndrome.
In PXE, there is mineralization (accumulation of calcium and other minerals) and fragmentation of the elastin-containing fibers in connective tissue, but primarily in the midlaminar layer of the dermis, Bruch's membrane and the midsized arteries.

Williams syndrome

Williams-Beuren syndromeWilliamsWilliam's Syndrome
Other associated defects in elastin include Marfan syndrome, emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis, Buschke-Ollendorff syndrome, Menkes syndrome, pseudoxanthoma elasticum, and Williams syndrome.
CLIP2, ELN, GTF2I, GTF2IRD1, and LIMK1 are among the genes that are typically deleted from one chromosome in people with Williams syndrome.

Desmosine

To make mature elastin fibres, the tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine cross-linking molecules.
Desmosine is a component of elastin and cross links with its isomer, isodesmosine, giving elasticity to the tissue.

Skin

cutaneousskin cellanimal skin
Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder.
It consists of loose connective tissue and elastin.

Elastic cartilage

elastic
Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder.
The principal protein is elastin.

Coacervate

coacervation
Tropoelastin aggregates at physiological temperature due to interactions between hydrophobic domains in a process called coacervation.
Coacervates ( or ) are organic-rich droplets formed via liquid-liquid phase separation, mainly resulting from association of oppositely charged molecules (macro-ions, polyelectrolytes, polysaccharides, proteins, etc.) or from hydrophobic proteins (such as elastin-like polypeptides).

GLB1

Elastin receptorbeta-galactosidasegalactosidase, beta 1
The GLB1 gene also encodes an elastin binding protein.

Lysyl oxidase

LOXprotein-lysine 6-oxidaseLOX (gene)
The enzyme that performs the crosslinking is lysyl oxidase, using an in vivo Chichibabin pyridine synthesis reaction.
Lysyl oxidase is an extracellular copper-dependent enzyme that catalyzes formation of aldehydes from lysine residues in collagen and elastin precursors.

Isodesmosine

To make mature elastin fibres, the tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine cross-linking molecules.
Isodesmosine is a lysine derivative found in elastin.

Chichibabin pyridine synthesis

Chichibabin synthesispyridine synthesis reactionreaction mechanism
The enzyme that performs the crosslinking is lysyl oxidase, using an in vivo Chichibabin pyridine synthesis reaction.
Researchers found that protein-incorporated allysine, (deaminated lysine) from bovine ligamentum nuchae elastin fibers appeared to be pyridine crosslinked.

Supravalvular aortic stenosis

Supravalvar aortic stenosisSVAS
The large number of introns suggests that genetic recombination may contribute to the instability of the gene, leading to diseases such as SVAS.
Supravalvular aortic stenosis is associated with genetic damage at the Elastin gene locus on chromosome 7q11.23.

Elasticity (physics)

elasticityelasticelasticity theory
It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting.

Gene

genesnumber of genesgene sequence
In humans, elastin is encoded by the ELN gene.

Hydrophobe

hydrophobichydrophobicityhydrophobic interaction
The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues.

Glycine

GlyGglycinate
The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues.