Empathogen–entactogen

entactogenentactogenicempathogenempathogenicempathogen-entactogenempathogensentactogens
Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA).wikipedia
134 Related Articles

Psychoactive drug

psychoactivepsychotropicdrug
Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA).
Empathogen–entactogens

3,4-Methylenedioxyamphetamine

MDAtenamfetaminemethylenedioxyamphetamine
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
3,4-Methylenedioxyamphetamine (MDA), is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug.

3,4-Methylenedioxy-N-ethylamphetamine

MDEAmethylenedioxyethylamphetamineMDE
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
3,4-Methylenedioxy-N-ethylamphetamine ("MDEA"; also called "MDE" and colloquially, "Eve") is an empathogenic psychoactive drug.

3,4-Methylenedioxy-N-hydroxyamphetamine

MDOHMethylenedioxyhydroxyamphetamine3,4-Methylenedioxy-''N''-hydroxyamphetamine
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
3,4-Methylenedioxy-N-hydroxyamphetamine (MDOH, MDH, N-hydroxytenamphetamine) is an entactogen, psychedelic, and stimulant of the phenethylamine and amphetamine chemical classes.

Methylone

3,4-Methylenedioxy-''N''-methylcathinone
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
Methylone (also known as "3,4-methylenedioxy-N-methylcathinone", "MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and stimulant psychoactive drug.

Alpha-Methyltryptamine

α-MethyltryptamineAMTαMT
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
α-Methyltryptamine (abbreviated as αMT, AMT) is a psychedelic, stimulant, and entactogen drug of the tryptamine class.

Substituted amphetamine

amphetaminesamphetaminesubstituted amphetamines
This class of drug is distinguished from the classes of hallucinogen or psychedelic, and amphetamine or stimulant. Most entactogens are phenethylamines and amphetamines, although several, such as αMT and αET, are tryptamines.
The compounds in this class span a variety of pharmacological subclasses, including stimulants, empathogens, and hallucinogens, among others.

Alpha-Ethyltryptamine

α-ethyltryptamineetryptamineαET
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
α-Ethyltryptamine (αET, AET), also known as etryptamine (INN, BAN, USAN), is a psychedelic, stimulant, and entactogenic drug of the tryptamine class.

Substituted phenethylamine

phenethylaminephenethylaminesphenethylamine class
Most entactogens are phenethylamines and amphetamines, although several, such as αMT and αET, are tryptamines.
Many substituted phenethylamines are psychoactive drugs which belong to a variety of different drug classes, including central nervous system stimulants (e.g., amphetamine), hallucinogens (e.g., dl-2,5-dimethoxy-4-methylamphetamine DOM), entactogens (e.g., 3,4-methylenedioxyamphetamine MDA), appetite suppressants (e.g. phentermine), nasal decongestants and bronchodilators (e.g., levomethamphetamine and pseudoephedrine), antidepressants (e.g. bupropion and phenelzine), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others.

Substituted methylenedioxyphenethylamine

MDxxList of substituted methylenedioxyphenethylaminesmethylenedioxylated
When referring to MDMA and its counterparts, the term MDxx is often used (with the exception of MDPV).
Substituted methylenedioxy- phenethylamines (MD xx ) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens.

Psychedelic drug

psychedelicpsychedelicspsychedelic drugs
This class of drug is distinguished from the classes of hallucinogen or psychedelic, and amphetamine or stimulant. The chemicals below have a varying degree of entactogenic effects; some of them induce additional effects, including serenic effects, stimulant effects, antidepressant effects, anxiolytic effects, and psychedelic effects. Both terms adopted and used in naming the class of therapeutic drugs for MDMA and related compounds were chosen with the intention of providing some reflection of the reported psychological effects associated with drugs in the classification and distinguishing these compounds from classical psychedelic drugs such as LSD, mescaline, and psilocybin and major stimulants, such as methamphetamine and amphetamine.
The empathogen-entactogens are phenethylamines of the MDxx class such as MDMA, MDEA, and MDA.

David E. Nichols

David Nichols
The term empathogen, meaning "generating a state of empathy", was coined in 1983–84 independently by Ralph Metzner and David E. Nichols as a term to denote a therapeutic class of drugs that includes MDMA and phenethylamine relatives.
His contributions include the synthesis and reporting of escaline, LSZ, 6-APB, 2C-I-NBOMe and other NBOMe variants (NBOMe-2C-B, NBOMe-2C-C, NBOMe-2C-D), and several others, as well as the coining of the term "entactogen".

Hallucinogen

hallucinogenicpsychedelic drughallucinogens
This class of drug is distinguished from the classes of hallucinogen or psychedelic, and amphetamine or stimulant.
Empathogen–entactogens such as MDA

Serenic

antiaggressive
The chemicals below have a varying degree of entactogenic effects; some of them induce additional effects, including serenic effects, stimulant effects, antidepressant effects, anxiolytic effects, and psychedelic effects.
The recreational drug MDMA ("ecstasy") and a variety of related drugs have been described as empathogen-entactogens, or simply as entactogens.

6-APB

6-(2-Aminopropyl)benzofuran
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
6-APB (6-(2-aminopropyl)benzofuran) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes.

5-APDI

5-(2-Aminopropyl)-2,3-dihydro-1H-indene5-Indanyl-2-aminopropaneIAP
5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI, IAP)
5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP), IAP (psychedelic), 2-API(2-aminopropylindane), indanametamine, and, incorrectly, as indanylamphetamine, is an entactogen and psychedelic drug of the amphetamine family.

5-APB

5-(2-aminopropyl)benzofuran
5-(2-aminopropyl)benzofuran (5-APB)
5-APB (abbreviation of "5-(2-aminopropyl)benzofuran"; see infobox for the correct IUPAC name) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes.

MBDB

methylbenzodioxylbutanamineMethyl-JN''-methyl-1,3-benzodioxolylbutanamine
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
1,3-Benzodioxolyl-N-methylbutanamine (N-methyl-1,3-benzodioxolylbutanamine, MBDB, 3,4-methylenedioxy-N-methyl-α-ethylphenylethylamine) is an entactogen of the phenethylamine chemical class.

Stimulant

psychostimulantstimulantspsychostimulants
This class of drug is distinguished from the classes of hallucinogen or psychedelic, and amphetamine or stimulant. The chemicals below have a varying degree of entactogenic effects; some of them induce additional effects, including serenic effects, stimulant effects, antidepressant effects, anxiolytic effects, and psychedelic effects. Both terms adopted and used in naming the class of therapeutic drugs for MDMA and related compounds were chosen with the intention of providing some reflection of the reported psychological effects associated with drugs in the classification and distinguishing these compounds from classical psychedelic drugs such as LSD, mescaline, and psilocybin and major stimulants, such as methamphetamine and amphetamine.
Some stimulants, notably those with empathogenic and hallucinogenic effects alter serotonergic neurotransmission.

MDMA

ecstasymethylenedioxymethamphetamineE
Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA). The term empathogen, meaning "generating a state of empathy", was coined in 1983–84 independently by Ralph Metzner and David E. Nichols as a term to denote a therapeutic class of drugs that includes MDMA and phenethylamine relatives. Both terms adopted and used in naming the class of therapeutic drugs for MDMA and related compounds were chosen with the intention of providing some reflection of the reported psychological effects associated with drugs in the classification and distinguishing these compounds from classical psychedelic drugs such as LSD, mescaline, and psilocybin and major stimulants, such as methamphetamine and amphetamine.
Entactogenic effects – increased empathy or feelings of closeness with others and oneself

MDAI

5,6-Methylenedioxy-2-aminoindane
Major members of this class include MDMA, MDA, MDEA, MDOH, MBDB, 6-APB, methylone, mephedrone, αMT, and αET, MDAI among others.
It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) in vitro and produces entactogen effects in humans.

Alexander Shulgin

ShulginAlexander "Sasha" ShulginAlexander
* Nichols, D.E., Hoffman, A.J., Oberlender, R.A., Jacob P 3rd & Shulgin A.T. Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class 1986 J Med Chem 29 2009-15
He is credited with introducing MDMA ("ecstasy", "mandy" or "molly") to psychologists in the late 1970s for psychopharmaceutical use and for the discovery, synthesis and personal bioassay of over 230 psychoactive compounds for their psychedelic and entactogenic potential.

Amphetamine

speedbenzedrineamphetamines
Both terms adopted and used in naming the class of therapeutic drugs for MDMA and related compounds were chosen with the intention of providing some reflection of the reported psychological effects associated with drugs in the classification and distinguishing these compounds from classical psychedelic drugs such as LSD, mescaline, and psilocybin and major stimulants, such as methamphetamine and amphetamine.
The class includes amphetamine itself, stimulants like methamphetamine, serotonergic empathogens like MDMA, and decongestants like ephedrine, among other subgroups.

5-IAI

5-Iodo-2-aminoindane
5-Iodo-2-aminoindane (5-IAI)
5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.

Serotonin

5-HTserotonergic5-hydroxytryptamine
There is also a potential concern for the neurotoxic effects of MDMA on the fiber density of serotonin neurons in the neocortex.
Several classes of drugs target the 5-HT system, including some antidepressants, antipsychotics, anxiolytics, antiemetics, and antimigraine drugs, as well as the psychedelic drugs and empathogens.