Long-term memory is commonly labelled as explicit memory (declarative), as well as episodic memory, semantic memory, autobiographical memory, and implicit memory (procedural memory).

- Long-term memory

Along with semantic memory, it comprises the category of explicit memory, one of the two major divisions of long-term memory (the other being implicit memory).

- Episodic memory

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Overall

Overview of the forms and functions of memory.

Memory

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Faculty of the mind by which data or information is encoded, stored, and retrieved when needed.

Faculty of the mind by which data or information is encoded, stored, and retrieved when needed.

Overview of the forms and functions of memory.
Olin Levi Warner, Memory (1896). Library of Congress Thomas Jefferson Building, Washington, D.C.
The working memory model
The garden of oblivion, illustration by Ephraim Moses Lilien.
Regulatory sequence in a promoter at a transcription start site with a paused RNA polymerase and a TOP2B-induced double-strand break
Brain regions involved in memory formation including medial prefrontal cortex (mPFC)
Regulatory sequence in a promoter at a transcription start site with a paused RNA polymerase and a TOP2B-induced double-strand break

Memory is often understood as an informational processing system with explicit and implicit functioning that is made up of a sensory processor, short-term (or working) memory, and long-term memory.

Under declarative memory resides semantic and episodic memory.

Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.

Hippocampus

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Major component of the brain of humans and other vertebrates.

Major component of the brain of humans and other vertebrates.

Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.
Image 1: The human hippocampus and fornix (left) compared with a seahorse (right)
Image 2: Cross-section of cerebral hemisphere showing structure and location of hippocampus
Image 3: Coronal section of the brain of a macaque monkey, showing hippocampus (circled)
Image 4: Basic circuit of the hippocampus, as drawn by Cajal DG: dentate gyrus. Sub: subiculum. EC: entorhinal cortex
Image 5: Hippocampal location and regions
Rats and cognitive maps
Image 6: Spatial firing patterns of 8 place cells recorded from the CA1 layer of a rat. The rat ran back and forth along an elevated track, stopping at each end to eat a small food reward. Dots indicate positions where action potentials were recorded, with color indicating which neuron emitted that action potential.
Image 7: Examples of rat hippocampal EEG and CA1 neural activity in the theta (awake/behaving) and LIA (slow-wave sleep) modes. Each plot shows 20 seconds of data, with a hippocampal EEG trace at the top, spike rasters from 40 simultaneously recorded CA1 pyramidal cells in the middle (each raster line represents a different cell), and a plot of running speed at the bottom. The top plot represents a time period during which the rat was actively searching for scattered food pellets. For the bottom plot the rat was asleep.
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Image 9: An EEG showing epilepsy right-hippocampal seizure onset
Image 10: An EEG showing epilepsy left-hippocampal seizure onset
Image 11: Drawing by Italian pathologist Camillo Golgi of a hippocampus stained using the silver nitrate method
thumb|Hippocampus highlighted in green on coronal T1 MRI images
thumb|Hippocampus highlighted in green on sagittal T1 MRI images
thumb|Hippocampus highlighted in green on transversal T1 MRI images

The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation.

Over the years, three main ideas of hippocampal function have dominated the literature: response inhibition, episodic memory, and spatial cognition.

Hippocampus as seen in red

Explicit memory

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Hippocampus as seen in red
Amygdala as seen in red
The Morris water maze

Explicit memory (or declarative memory) is one of the two main types of long-term human memory, the other of which is implicit memory.

Explicit memory can be divided into two categories: episodic memory, which stores specific personal experiences, and semantic memory, which stores factual information.

Hippocampus (brain)

Anterograde amnesia

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Hippocampus (brain)

In neurology, anterograde amnesia is a loss of the ability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

Furthermore, the data do not explain the dichotomy that exists in the MTL memory system between episodic memory and semantic memory (described below).

Lobes of the human brain (temporal lobe is shown in green)

Temporal lobe

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One of the four major lobes of the cerebral cortex in the brain of mammals.

One of the four major lobes of the cerebral cortex in the brain of mammals.

Lobes of the human brain (temporal lobe is shown in green)
Animation showing the position of the human left temporal lobe

Declarative (denotative) or explicit memory is conscious memory divided into semantic memory (facts) and episodic memory (events).

The temporal lobe communicates with the hippocampus and plays a key role in the formation of explicit long-term memory modulated by the amygdala.

The line processes to make information memory

Memory consolidation

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Category of processes that stabilize a memory trace after its initial acquisition.

Category of processes that stabilize a memory trace after its initial acquisition.

The line processes to make information memory
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Long-term memory, when discussed in the context of synaptic consolidation, is conventionally said to be memory that lasts for at least 24 hours.

Multiple trace theory (MTT) builds on the distinction between semantic memory and episodic memory and addresses perceived shortcomings of the standard model with respect to the dependency of the hippocampus.

Amnesie

Amnesia

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Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Amnesie

Anterograde amnesia is the inability to transfer new information from the short-term store into the long-term store.

Retrograde amnesia is inability to recall memories before onset of amnesia. One may be able to encode new memories after the incident. Retrograde is usually caused by head trauma or brain damage to parts of the brain besides the hippocampus. The hippocampus is responsible for encoding new memory. Episodic memory is more likely to be affected than semantic memory. The damage is usually caused by head trauma, cerebrovascular accident, stroke, tumor, hypoxia, encephalitis, or chronic alcoholism. People with retrograde amnesia are more likely to remember general knowledge rather than specifics. Recent memories are less likely to be recovered, but older memories will be easier to recall due to strengthening over time. Retrograde amnesia is usually temporary and can be treated by exposing them to memories from the loss. Another type of consolidation (process by which memories become stable in the brain) occurs over much longer periods of time/days, weeks, months and years and likely involves transfer of information from the hippocampus to more permanent storage site in the cortex. The operation of this longer-term consolidation process is seen in the retrograde amnesia of patients with hippocampal damage who can recall memories from childhood relatively normally, but are impaired when recalling experiences that occurred just a few years prior to the time they became amnesic. (Kirwan et al.,2008)In the case of LSJ, her case shows that retrograde amnesia can affect many different parts of knowledge. LSJ was not able to remember things from her child or adult life. She was not able to remember things that most people pick up in everyday life such as logos or the names of common songs.

Hermann Ebbinghaus

Recall (memory)

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Recall in memory refers to the mental process of retrieval of information from the past.

Recall in memory refers to the mental process of retrieval of information from the past.

Hermann Ebbinghaus
Cerebellum highlighted in red
Globus pallidus highlighted in red
Hippocampus highlighted in red
Anterior cingulate cortex
A visual representation of Spreading Activation
Jorge Luis Borges in 1951

Tulving described episodic memory as a memory about a specific event that occurred at a particular time and place, for example what you got for your 10th birthday.

Semantic memories are abstract words, concepts, and rules stored in long-term memory.

Drawing comparing a normal aged brain (left) and the brain of a person with Alzheimer's. Characteristics that separate the two are pointed out.

Alzheimer's disease

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Neurodegenerative disease that usually starts slowly and progressively worsens.

Neurodegenerative disease that usually starts slowly and progressively worsens.

Drawing comparing a normal aged brain (left) and the brain of a person with Alzheimer's. Characteristics that separate the two are pointed out.
Stages of atrophy in Alzheimer's.
A normal brain on the left and a late-stage Alzheimer's brain on the right
In Alzheimer's disease, changes in tau protein lead to the disintegration of microtubules in brain cells.
Histopathologic images of Alzheimer's disease, in the CA3 area of the hippocampus, showing an amyloid plaque (top right), neurofibrillary tangles (bottom left), and granulovacuolar degeneration bodies (bottom center)
PET scan of the brain of a person with Alzheimer's disease showing a loss of function in the temporal lobe
Cognitive tests such as the Mini–Mental State Examination (MMSE) can help in the diagnosis of Alzheimer's disease. In this test instructions are given to copy drawings like the one shown, remember some words, read, and subtract numbers serially.
Intellectual activities such as playing chess or regular social interaction have been linked to a reduced risk of Alzheimer's disease in epidemiological studies, although no causal relationship has been found.
Three-dimensional molecular model of donepezil, an acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease symptoms
Molecular structure of memantine, a medication approved for advanced Alzheimer's disease symptoms
Alois Alzheimer's patient Auguste Deter in 1902. Hers was the first described case of what became known as Alzheimer's disease.
Self-portrait of artist William Utermohlen, created after Alzheimer's disease diagnosis

Older memories of the person's life (episodic memory), facts learned (semantic memory), and implicit memory (the memory of the body on how to do things, such as using a fork to eat or how to drink from a glass) are affected to a lesser degree than new facts or memories.

Baddeley and Hitch's model of working memory

Working memory

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Cognitive system with a limited capacity that can hold information temporarily.

Cognitive system with a limited capacity that can hold information temporarily.

Baddeley and Hitch's model of working memory

The episodic buffer resembles Tulving's concept of episodic memory, but it differs in that the episodic buffer is a temporary store.

In a similar vein, Cowan does not regard working memory as a separate system from long-term memory.