ErbB

EGFR familyEpidermal growth factor receptor familyEGF receptor familyEGFRepidermal growth factor receptor (EGFR/ERBB) familyepidermal growth factor receptor (HER/EGFR/ERBB) familyErbB familyErbB family of receptorserbB geneERBB receptors
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.wikipedia
59 Related Articles

Receptor tyrosine kinase

receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptors
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.

Epidermal growth factor receptor

EGFREGF receptorEGFR inhibitor
In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4).
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4).

HER2/neu

HER2ERBB2HER-2
In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4).
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family.

ERBB3

HER3receptor, erbb-3erbB-3
In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4).
ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases.

ERBB4

HER4ErbB-4Her 4
In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4).
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor family.

Neuregulin 1

NRG1neuregulin-1heregulin
NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors.

Gefitinib

Iressa
Drugs such as panitumumab, cetuximab, gefitinib, erlotinib, afatinib, and lapatinib are used to inhibit it.
The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4).

Epiregulin

EREG
Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.

Neuregulin

neuregulinsneuregulin 2neuregulin-2
A study done on mice in early 2009 has indicated that when neuregulin-1\ErbB signalling is disrupted, the dendritic spines of neurons grow but do not fully form.

Neurodegeneration

neurodegenerativeneurodegenerative diseaseneurodegenerative diseases
Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor.

Multiple sclerosis

MSmultiple sclerosis (MS)disseminated sclerosis
Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor.

Alzheimer's disease

AlzheimerAlzheimer’s diseaseAlzheimer disease
Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor.

Neoplasm

tumortumorstumour
Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors.

Schwann cell

Schwann cellsSchwannschwann cell transplant
Lack of Schwann cell maturation leads to degeneration of motor and sensory neurons.

Cancer

cancersmalignanciescancerous
ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors.

Malignancy

malignantmalignanciesmalignant cells
ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors.

Extracellular

extracellular spaceextracellular environment[2
This structure is made up of an extracellular region or ectodomain or ligand binding region that contains approximately 620 amino acids, a single transmembrane-spanning region containing approximately 23 residues, and an intracellular cytoplasmic tyrosine kinase domain containing up to approximately 540 residues.

Amino acid

amino acidsresiduesresidue
This structure is made up of an extracellular region or ectodomain or ligand binding region that contains approximately 620 amino acids, a single transmembrane-spanning region containing approximately 23 residues, and an intracellular cytoplasmic tyrosine kinase domain containing up to approximately 540 residues.

Transmembrane protein

transmembranetransmembrane proteinstype I
This structure is made up of an extracellular region or ectodomain or ligand binding region that contains approximately 620 amino acids, a single transmembrane-spanning region containing approximately 23 residues, and an intracellular cytoplasmic tyrosine kinase domain containing up to approximately 540 residues.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
This structure is made up of an extracellular region or ectodomain or ligand binding region that contains approximately 620 amino acids, a single transmembrane-spanning region containing approximately 23 residues, and an intracellular cytoplasmic tyrosine kinase domain containing up to approximately 540 residues.

Leucine

LeuL-leucineL
The extracellular region of each family member is made up of 4 subdomains, L1, CR1, L2, and CR2, where "L" signifies a leucine-rich repeat domain and "CR" a cysteine-rich region, and these CR domains contain disulfide modules in their structure as 8 disulfide modules in CR1 domain, whereas 7 modules in CR2 domain.

Cysteine

CysL-cysteinecystein
The extracellular region of each family member is made up of 4 subdomains, L1, CR1, L2, and CR2, where "L" signifies a leucine-rich repeat domain and "CR" a cysteine-rich region, and these CR domains contain disulfide modules in their structure as 8 disulfide modules in CR1 domain, whereas 7 modules in CR2 domain.

Protein Data Bank (file format)

PDBProtein Data BankPDB format
The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4):

Protein dimer

heterodimerdimerhomodimer
The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands.

Biomolecular structure

structuresstructuretertiary structure
The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands.