Erythema nodosum

erythema nodosum leprosumAcute erythema nodosumChronic erythema nodosumerythema nodosum leprosum (ENL)
Erythema nodosum (EN), is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins.wikipedia
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Crohn's disease

Crohn’s diseaseCrohn diseaseCrohn
The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum.

Sarcoidosis

pulmonary sarcoidosissarcoidBoeck's sarcoid
A chest X-ray should be performed to rule out pulmonary diseases, in particular sarcoidosis and Löfgren syndrome.
Some may have Löfgren syndrome with fever, large lymph nodes, arthritis, and a rash known as erythema nodosum.

Coccidioidomycosis

Valley feverCoccidiomycosisSan Joaquin Valley Fever
The classic triad of coccidioidomycosis known as "desert rheumatism" includes the combination of fever, joint pains, and erythema nodosum.

Behçet's disease

Behcet's diseaseBehcet syndromeBehcet's syndrome
Additionally, patients may present with erythema nodosum, cutaneous pustular vasculitis, and lesions similar to pyoderma gangrenosum.

Thalidomide

ThalomidConterganThalidomide Syndrome
Thalidomide has been used successfully in the treatment of Erythema nodosum leprosum, and it was approved by the U.S. FDA for this use in July 1998.
Thalidomide is used as a first-line treatment in multiple myeloma in combination with dexamethasone or with melphalan and prednisone, to treat acute episodes of erythema nodosum leprosum, and for maintenance therapy.

Löfgren syndrome

A chest X-ray should be performed to rule out pulmonary diseases, in particular sarcoidosis and Löfgren syndrome.
It is characterized by enlargement of the lymph nodes near the inner border of the lungs (called "hilar lymphadenopathy") as seen on x-ray, and tender red nodules (erythema nodosum) are classically present on the shins, predominantly in women.

Potassium iodide

KISSKIPotassium iodide (KI)
Potassium iodide can be used for persistent lesions whose cause remains unknown.

Inflammation

inflammatoryinflammatory responseinflamed
Erythema nodosum (EN), is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins.

Panniculitis

Alpha-1 antitrypsin deficiency panniculitisPancreatic panniculitisSclerosing lipogranuloma
Erythema nodosum (EN), is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins.

Malaise

a general sense of feeling unwellgeneral discomfortfeeling generally unwell
The first signs of erythema nodosum are often flu-like symptoms such as a fever, cough, malaise, and aching joints.

Nodule (medicine)

nodulesnodulenodular
Erythema nodosum is characterised by 1 – nodules (rounded lumps) below the skin surface, usually on the shins.

Subcutaneous tissue

subcutaneoussubcutaneous fathypodermis
These subcutaneous nodules can appear anywhere on the body, but the most common sites are the shins, arms, thighs, and torso.

Lepromatous leprosy

lepromatousleprosyleprosy, lepromatous
EN may also be due to excessive antibody production in lepromatous leprosy leading to deposition of immune complexes.

Immune complex

immune complexesantigen-antibody complexantigen-antibody complexes
EN may also be due to excessive antibody production in lepromatous leprosy leading to deposition of immune complexes.

HLA-B27

HLA B27B27HLA-B*27
There is an association with the HLA-B27 histocompatibility antigen, which is present in 65% of patients with erythema nodosum.

List of medical mnemonics

mnemonicmemory aid
A useful mnemonic for causes is SORE SHINS (Streptococci, OCP, Rickettsia, Eponymous (Behçet), Sulfonamides, Hansen's Disease (Leprosy), IBD, NHL, Sarcoidosis.

Coccidioides immitis

coccidioidinCoccidiodes immitisCoccidioides immitis RS