A report on Estrogen receptor and Estrone

A dimer of the ligand-binding region of ERβ (PDB rendering based on ).
Comprehensive overview of steroidogenesis, showing estrone on the lower right among the estrogens.
The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation.
A dimer of the ligand-binding region of ERα (PDB rendering based on ).
Nolvadex (tamoxifen) 20 mg
Arimidex (anastrozole) 1 mg

Estrone is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ.

- Estrone

Endogenous estrogens (e.g., estradiol, estrone, estriol, estetrol)

- Estrogen receptor
A dimer of the ligand-binding region of ERβ (PDB rendering based on ).

7 related topics with Alpha

Overall
Human steroidogenesis, showing estradiol at bottom right.

Estradiol

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Estrogen steroid hormone and the major female sex hormone.

Estrogen steroid hormone and the major female sex hormone.

Human steroidogenesis, showing estradiol at bottom right.
Estradiol levels across the menstrual cycle in 36 normally cycling, ovulatory women, based on 956 specimens. The horizontal dashed lines are the mean integrated levels for each curve. The vertical dashed line in the center is mid-cycle.

The major pathway involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol.

The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including in keratinocytes and fibroblasts.

Human steroidogenesis, showing estriol at bottom right. In essence, it follows the pathway from dehydroepiandrosterone or DHEA (at left), but with a modified DHEA with an additional OH-group.

Estriol

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Steroid, a weak estrogen, and a minor female sex hormone.

Steroid, a weak estrogen, and a minor female sex hormone.

Human steroidogenesis, showing estriol at bottom right. In essence, it follows the pathway from dehydroepiandrosterone or DHEA (at left), but with a modified DHEA with an additional OH-group.

It is one of three major endogenous estrogens, the others being estradiol and estrone.

Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ.

Estradiol, the major estrogen sex hormone in humans and a widely used medication.

Estrogen

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Category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics.

Category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics.

Estradiol, the major estrogen sex hormone in humans and a widely used medication.
Reference ranges for the blood content of estradiol, the primary type of estrogen, during the menstrual cycle.
Steroidogenesis, showing estrogens at bottom right as in pink triangle.

There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3).

Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes.

Estrogen receptor alpha

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Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.

Endogenous estrogens (e.g., estradiol, estrone, estriol, estetrol)

GPER

3 links

Protein that in humans is encoded by the GPER gene.

Protein that in humans is encoded by the GPER gene.

The classical estrogen receptors first characterized in 1958 are water-soluble proteins located in the interior of cells that are activated by estrogenenic hormones such as estradiol and several of its metabolites such as estrone or estriol.

Estrogen receptor beta

3 links

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.

Endogenous estrogens (e.g., estradiol, estrone, estriol, estetrol)

Aromatase

2 links

Enzyme responsible for a key step in the biosynthesis of estrogens.

Enzyme responsible for a key step in the biosynthesis of estrogens.

It catalyzes the last steps of estrogen biosynthesis from androgens (specifically, it transforms androstenedione to estrone and testosterone to estradiol).

Aromatase inhibitors, which stop the production of estrogen in postmenopausal women, have become useful in the management of patients with breast cancer whose lesion was found to be estrogen receptor positive.