A report on Estrogen receptor and Mammary gland

A dimer of the ligand-binding region of ERβ (PDB rendering based on ).
Cross-section of the human mammary gland. 1. Chest wall 2. Pectoralis muscles 3. Lobules 4. Nipple 5. Areola 6. Milk duct 7. Fatty tissue 8. Skin
The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation.
Cross-section of the human mammary gland. 1. Chest wall 2. Pectoralis muscles 3. Lobules 4. Nipple 5. Areola 6. Milk duct 7. Fatty tissue 8. Skin
A dimer of the ligand-binding region of ERα (PDB rendering based on ).
Light micrograph of a human proliferating mammary gland during estrous cycle. Sprouting gland tissue can be seen in the upper left field (haematoxylin eosin staining)
Nolvadex (tamoxifen) 20 mg
Cross section of the breast of a human female
Arimidex (anastrozole) 1 mg
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Cattle
Cat
Pig
Goat
Elephant

However, GH itself also acts independently of IGF-1 to stimulate ductal development by upregulating estrogen receptor (ER) expression in mammary gland tissue, which is a downstream effect of mammary gland GHR activation.

- Mammary gland

First, binding of estrogen to the ER stimulates proliferation of mammary cells, with the resulting increase in cell division and DNA replication, leading to mutations.

- Estrogen receptor
A dimer of the ligand-binding region of ERβ (PDB rendering based on ).

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