A report on Ovarian cancer and Estrogen receptor

Micrograph of a mucinous ovarian carcinoma stained by H&E.

A dimer of the ligand-binding region of ERβ (PDB rendering based on ).

The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation.

Women with ovarian or breast cancer in a pedigree chart of a family

A dimer of the ligand-binding region of ERα (PDB rendering based on ).

A very large ovarian cancer as seen on CT

Micrograph of serous carcinoma, a type of ovarian cancer, diagnosed in peritoneal fluid

Ovarian cancers in women aged 20+, with area representing relative incidence and color representing five-year relative survival rate

A pathological specimen of ovarian carcinoma

Hobnail cells seen in a clear cell carcinoma sample

Ovarian adenocarcinoma deposit in the mesentery of the small bowel

Relative five-year survival of invasive epithelial ovarian cancer by stage

Ovarian tumors (including non-cancerous tumors) by incidence and risk of ovarian cancer.

Ovarian cancer cases diagnosed by age group in the US

Age-standardized death from ovarian cancer per 100,000 inhabitants in 2004
no data
less than 0.6
0.6–1.2
1.2–1.8
1.8–2.4
2.4–3
3–3.6
3.6–4.2
4.2–4.8
4.8–5.4
5.4–6
6–7
more than 7

Estrogen and the ERs have also been implicated in breast cancer, ovarian cancer, colon cancer, prostate cancer, and endometrial cancer.

- Estrogen receptor

Despite the fact that 60% of ovarian tumors have estrogen receptors, ovarian cancer is only rarely responsive to hormonal treatments.

- Ovarian cancer

3 related topics with Alpha

Breast cancer

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Cancer that develops from breast tissue.

Breast cancer showing an inverted nipple, lump, and skin dimpling

Tumor in the breast visualized by Breast-Computertomography (Breast-CT)

All types of alcoholic beverages, including beer, wine, or liquor, cause breast cancer.

Ducts and lobules, the main locations of breast cancers

Overview of signal transduction pathways involved in programmed cell death. Mutations leading to loss of this ability can lead to cancer formation.

Histopathologic types of breast cancer, with relative incidences and prognoses

A mobile breast cancer screening unit in New Zealand

Breasts after double mastectomy followed by nipple-sparing reconstruction with implants

An extreme example of an advanced recurrent breast cancer with an ulcerating axillary mass

Radical mastectomy, Halsted's surgical papers

The pink ribbon is a symbol to show support for breast cancer awareness.

Excised human breast tissue, showing an irregular, dense, white stellate area of cancer 2cm in diameter, within yellow fatty tissue

High-grade invasive ductal carcinoma, with minimal tubule formation, marked pleomorphism, and prominent mitoses, 40x field

Micrograph showing a lymph node invaded by ductal breast carcinoma, with an extension of the tumor beyond the lymph node

Neuropilin-2 expression in normal breast and breast carcinoma tissue

F-18 FDG PET/CT: A breast cancer metastasis to the right scapula

Elastography shows stiff cancer tissue on ultrasound imaging.

Ultrasound image shows irregularly shaped mass of breast cancer.

Infiltrating (invasive) breast carcinoma

Mammograms showing a normal breast (left) and a breast with cancer (right)

Additionally, G-protein coupled estrogen receptors have been associated with various cancers of the female reproductive system including breast cancer.

In the United States, 10 to 20 percent of women with breast cancer or ovarian cancer have a first- or second-degree relative with one of these diseases.

Endometrial cancer

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Cancer that arises from the endometrium .

The autosomal dominant inheritance pattern seen in Lynch syndrome

Immunohistochemistry of endometrial endometrioid carcinoma with wild-type pattern of p53 expression, with variable proportion of tumor cell nuclei staining with variable intensity.

Vaginal ultrasonography with an endometrial fluid accumulation (darker area) in a postmenopausal uterus, a finding that is highly suspicious for endometrial cancer

Relative incidences of endometrial carcinomas by histopathology.

Endometrioid endometrial adenocarcinoma—very high magnification—H&E stain

A keyhole hysterectomy, one possible surgery to treat endometrial cancer

alt=A diagram of stage IA and IB endometrial cancer|Stage IA and IB endometrial cancer

alt=A diagram of stage II endometrial cancer|Stage II endometrial cancer

alt=A diagram of stage III endometrial cancer|Stage III endometrial cancer

alt=A diagram of stage IV endometrial cancer|Stage IV endometrial cancer

This makes it the third most common cause of death in cancers which only affect women, behind ovarian and cervical cancer.

This treatment is effective in endometrial stromal sarcomas because they typically have estrogen and/or progestin receptors.

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.

ERβ is a potent tumor suppressor and plays a crucial role in many cancer types such as prostate cancer and ovarian cancer.