A report on Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
- Estrogen receptor42 related topics with Alpha
Coumestrol
2 linksNatural organic compound in the class of phytochemicals known as coumestans.
Natural organic compound in the class of phytochemicals known as coumestans.
However, continued exposure inhibited the growth of the uterus and decreased levels of estrogen receptors within uterine tissue.
Sp1 transcription factor
1 linksProtein that in humans is encoded by the SP1 gene.
Protein that in humans is encoded by the SP1 gene.
Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level.
Osteoporosis
3 linksSystemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk.
Systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk.
The α-form of the estrogen receptor appears to be the most important in regulating bone turnover.
Hormone receptor positive breast tumor
0 linksTumor which consists of cells that express receptors for certain hormones.
Tumor which consists of cells that express receptors for certain hormones.
The term most commonly refers to estrogen receptor positive tumors (i.e. tumors that contain estrogen receptor positive cells), but can also include progesterone receptor positive tumors.
Elwood V. Jensen
1 linksThe Distinguished University Professor, George and Elizabeth Wile Chair in Cancer Research at the University of Cincinnati College of Medicine's Vontz Center for Molecular Studies.
The Distinguished University Professor, George and Elizabeth Wile Chair in Cancer Research at the University of Cincinnati College of Medicine's Vontz Center for Molecular Studies.
In 2004 he received the Albert Lasker Award for Basic Medical Research for his research on estrogen receptors.
ICI-164384
0 linksSteroidal antiestrogen and a synthetic derivative of estradiol which is closely related to fulvestrant and was never marketed.
Steroidal antiestrogen and a synthetic derivative of estradiol which is closely related to fulvestrant and was never marketed.
It is a silent antagonist of the estrogen receptor (ER) with no intrinsic estrogenic activity and hence is a pure antiestrogen, unlike selective estrogen receptor modulators (SERMs) like tamoxifen.
Endometrial cancer
4 linksCancer that arises from the endometrium .
Cancer that arises from the endometrium .
This treatment is effective in endometrial stromal sarcomas because they typically have estrogen and/or progestin receptors.
Mammary gland
0 linksExocrine gland in humans and other mammals that produces milk to feed young offspring.
Exocrine gland in humans and other mammals that produces milk to feed young offspring.
However, GH itself also acts independently of IGF-1 to stimulate ductal development by upregulating estrogen receptor (ER) expression in mammary gland tissue, which is a downstream effect of mammary gland GHR activation.
Ovarian cancer
3 linksCancer that forms in or on an ovary.
Cancer that forms in or on an ovary.
Despite the fact that 60% of ovarian tumors have estrogen receptors, ovarian cancer is only rarely responsive to hormonal treatments.
Aromatase
5 linksEnzyme responsible for a key step in the biosynthesis of estrogens.
Enzyme responsible for a key step in the biosynthesis of estrogens.
Aromatase inhibitors, which stop the production of estrogen in postmenopausal women, have become useful in the management of patients with breast cancer whose lesion was found to be estrogen receptor positive.