A report on Extracellular matrix
Three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
- Extracellular matrix53 related topics with Alpha
Collagen
10 linksCollagen is the main structural protein in the extracellular matrix found in the body's various connective tissues.
Basement membrane
7 linksThe basement membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling.
Integrin
9 linksIntegrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion.
Epithelium
5 linksOne of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
One of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
It is a thin, continuous, protective layer of compactly packed cells with a little intercellular matrix.
Focal adhesion
6 linksIn cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell.
Wound healing
6 linksWound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.
Proliferation (growth of new tissue): In this phase, angiogenesis, collagen deposition, granulation tissue formation, epithelialization, and wound contraction occur. In angiogenesis, vascular endothelial cells form new blood vessels. In fibroplasia and granulation tissue formation, fibroblasts grow and form a new, provisional extracellular matrix (ECM) by excreting collagen and fibronectin. Concurrently, re-epithelialization of the epidermis occurs, in which epithelial cells proliferate and 'crawl' atop the wound bed, providing cover for the new tissue. In wound contraction, myofibroblasts decrease the size of the wound by gripping the wound edges and contracting using a mechanism that resembles that in smooth muscle cells. When the cells' roles are close to complete, unneeded cells undergo apoptosis.
Fibronectin
4 linksFibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.
Lung
4 linksThe lungs are the primary organs of the respiratory system in humans and most animals, some fish and some snails.
The lungs are the primary organs of the respiratory system in humans and most animals, some fish and some snails.
Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres.
Perlecan
3 linksProtein that in humans is encoded by the HSPG2 gene.
Protein that in humans is encoded by the HSPG2 gene.
Perlecan is a large multidomain (five domains, labeled I-V) proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules.