A report on Familial adenomatous polyposis
Autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine.
- Familial adenomatous polyposis19 related topics with Alpha
Colorectal cancer
7 linksDevelopment of cancer from the colon or rectum (parts of the large intestine).
Development of cancer from the colon or rectum (parts of the large intestine).
Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases.
Gardner's syndrome
4 links
Gardner's syndrome (also known as Gardner syndrome, familial polyposis of the colon, or familial colorectal polyposis ) is a subtype of familial adenomatous polyposis (FAP).
Cancer
4 linksGroup of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
COX-2 inhibitors may decrease the rate of polyp formation in people with familial adenomatous polyposis; however, it is associated with the same adverse effects as NSAIDs.
Adenomatous polyposis coli
2 linksProtein that in humans is encoded by the APC gene.
Protein that in humans is encoded by the APC gene.
Familial adenomatous polyposis (FAP) is caused by an inherited, inactivating mutation in the APC gene.
Catenin beta-1
2 linksProtein that in humans is encoded by the CTNNB1 gene.
Protein that in humans is encoded by the CTNNB1 gene.
Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Colorectal polyp
1 linksPolyp occurring on the lining of the colon or rectum.
Polyp occurring on the lining of the colon or rectum.
Familial adenomatous polyposis (FAP)
Polyp (medicine)
2 linksAbnormal growth of tissue projecting from a mucous membrane.
Abnormal growth of tissue projecting from a mucous membrane.
Familial adenomatous polyposis
Aggressive fibromatosis
1 linksRare condition.
Rare condition.
Most cases are sporadic, but some are associated with familial adenomatous polyposis (FAP).
Gardner fibroma
1 linksBenign fibroblastic tumor (i.e. a tumor containing fibroblasts, the most common cell type in connective tissue).
Benign fibroblastic tumor (i.e. a tumor containing fibroblasts, the most common cell type in connective tissue).
In the majority of cases, GF tumors are manifestations of the genetic disease, familial adenomatous polyposis (FAP), or its variant, the Gardner syndrome (GS).
Carcinogenesis
2 linksFormation of a cancer, whereby normal cells are transformed into cancer cells.
Formation of a cancer, whereby normal cells are transformed into cancer cells.
Other inherited tumor suppressor gene syndromes include Rb mutations, linked to retinoblastoma, and APC gene mutations, linked to adenopolyposis colon cancer.