Fatigue

exhaustionOverexertionfeeling tiredtirednesslassitudelethargylethargicchronic fatiguetiredfatigued
Fatigue is a subjective feeling of tiredness that has a gradual onset.wikipedia
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Sleep deprivation

deprived of sleepsleep deprivedlack of sleep
The onset of muscle fatigue during physical activity is gradual, and depends upon an individual's level of physical fitness, and also upon other factors, such as sleep deprivation and overall health. Fatigue is a normal result of working, mental stress, overstimulation and understimulation, jet lag or active recreation, depression, boredom, disease, and lack of sleep.
A chronic sleep-restricted state can cause fatigue, daytime sleepiness, clumsiness and weight loss or weight gain.

Somnolence

drowsinesssleepinessdrowsy
It can manifest as somnolence, lethargy, or directed attention fatigue.
When a person is sufficiently fatigued, microsleeps may be experienced.

Directed attention fatigue

attention fatigue
It can manifest as somnolence, lethargy, or directed attention fatigue.
It is rather a temporary fatigue of the inhibitory mechanisms in the brain.

Lethargy

lethargiclack of energydepression
It can manifest as somnolence, lethargy, or directed attention fatigue.
Lethargy is a state of tiredness, weariness, fatigue, or lack of energy.

Multiple sclerosis

MSdisseminated sclerosisMultiple sclerosis (MS)
People with multiple sclerosis experience a form of overwhelming lassitude or tiredness that can occur at any time of the day, for any duration, and that does not necessarily recur in a recognizable pattern for any given patient, referred to as "neurological fatigue". Autoimmune diseases such as celiac disease, lupus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
The specific symptoms are determined by the locations of the lesions within the nervous system, and may include loss of sensitivity or changes in sensation such as tingling, pins and needles or numbness, muscle weakness, blurred vision, very pronounced reflexes, muscle spasms, or difficulty in moving; difficulties with coordination and balance (ataxia); problems with speech or swallowing, visual problems (nystagmus, optic neuritis or double vision), feeling tired, acute or chronic pain, and bladder and bowel difficulties, among others.

Medical sign

signsclinical signsign
Fatigue is considered a symptom, rather than a sign, because it is a subjective feeling reported by the patient, rather than an objective one that can be observed by others.
Signs are different from symptoms, the subjective experiences, such as fatigue, that patients might report to their examining physician.

Anemia

anaemiaanemicanaemic
Chronic blood loss frequently results in fatigue, as do other conditions that cause anemia.
When anemia comes on slowly, the symptoms are often vague and may include feeling tired, weakness, shortness of breath or a poor ability to exercise.

Boredom

ennuiboringbored
Fatigue is a normal result of working, mental stress, overstimulation and understimulation, jet lag or active recreation, depression, boredom, disease, and lack of sleep.
Lethargy is a state of tiredness, weariness, fatigue, or lack of energy.

Symptom

symptomssymptomaticnon-specific symptom
Fatigue is considered a symptom, rather than a sign, because it is a subjective feeling reported by the patient, rather than an objective one that can be observed by others. Medically, fatigue is a non-specific symptom, which means that it has many possible causes and accompanies many different conditions.
For example, fatigue is a feature of many acute and chronic medical conditions, which may or may not be mental, and may be either a primary or secondary symptom.

Jet lag

jetlagjet-lagcircadian disruption
Fatigue is a normal result of working, mental stress, overstimulation and understimulation, jet lag or active recreation, depression, boredom, disease, and lack of sleep.
Cognitive effects include poorer performance on mental tasks and concentration; increased fatigue, headaches, and irritability; and problems with digestion, including indigestion, changes in the frequency of defecation and consistency of faeces, and reduced interest in and enjoyment of food.

Exercise intolerance

exerciseexercise toleranceexertional
Fatigue may also be a side effect of certain medications (e.g., lithium salts, ciprofloxacin); beta blockers, which can induce exercise intolerance; and many cancer treatments, particularly chemotherapy and radiotherapy.
It also includes experiences of unusually severe post-exercise pain, fatigue, nausea, vomiting or other negative effects.

Systemic lupus erythematosus

lupusSLEsystemic lupus
Autoimmune diseases such as celiac disease, lupus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is most commonly on the face.

Autoimmune disease

autoimmune diseasesautoimmune disorderautoimmune
Autoimmune diseases such as celiac disease, lupus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
Common symptoms include low grade fever and feeling tired.

Sjögren syndrome

sjogren's syndromeanti-La antibodiesSjögren's syndrome
Autoimmune diseases such as celiac disease, lupus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
Other symptoms can include dry skin, vaginal dryness, a chronic cough, numbness in the arms and legs, feeling tired, muscle and joint pains, and thyroid problems.

Chronic fatigue syndrome

myalgic encephalomyelitisMEchronic fatigue
Chronic fatigue syndrome (CFS)
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other persistent symptoms that limit a person's ability to carry out ordinary daily activities.

Coeliac disease

celiac diseasecoeliacceliac
Autoimmune diseases such as celiac disease, lupus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
The inability to absorb carbohydrates and fats may cause weight loss (or failure to thrive/stunted growth in children) and fatigue or lack of energy.

Common cold

coldcoldsnasopharyngitis
Temporary fatigue is likely to be a minor illness like the common cold as one part of the sickness behavior response that happens when the immune system fights an infection.
The typical symptoms of a cold include a cough, a runny nose, nasal congestion and a sore throat, sometimes accompanied by muscle ache, fatigue, headache, and loss of appetite.

Hypoglycemia

low blood sugarhypoglycemichypoglycaemia
It may also have chemical causes, such as poisoning, low blood sugar, or mineral or vitamin deficiencies.
Fatigue, weakness, apathy, lethargy, daydreaming, sleep

Fibromyalgia

fibrositismuscular rheumatismfibromyalgia syndrome
Fibromyalgia
Other symptoms include tiredness to a degree that normal activities are affected, sleep problems and troubles with memory.

Major depressive disorder

depressionclinical depressionmajor depression
Fatigue is a normal result of working, mental stress, overstimulation and understimulation, jet lag or active recreation, depression, boredom, disease, and lack of sleep.
A depressed person may report multiple physical symptoms such as fatigue, headaches, or digestive problems; physical complaints are the most common presenting problem in developing countries, according to the World Health Organization's criteria for depression.

Gulf War syndrome

Gulf War Illnessadverse health outcomesafter-effects of his service during the 1991 Gulf War
Gulf War syndrome
A wide range of acute and chronic symptoms have been linked to it, including fatigue, muscle pain, cognitive problems, rashes and diarrhea.

Alcohol abuse

alcoholalcohol misuseabusing alcohol
Drug abuse including alcohol abuse
Alcohol abuse is also an important cause of chronic fatigue.

Infectious mononucleosis

mononucleosisglandular fevermono
Infectious diseases such as infectious mononucleosis.
In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and tiredness.

Hypothyroidism

hypothyroidhypo-underactive thyroid
Endocrine diseases like diabetes mellitus and hypothyroidism

Diabetes mellitus

diabetesdiabeticdiabetics
Endocrine diseases like diabetes mellitus and hypothyroidism
In addition to the known ones above, they include blurred vision, headache, fatigue, slow healing of cuts, and itchy skin.