A report on Fibromyalgia and Pregabalin

The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia
Box of 150 mg Lyrica (pregabalin) capsules from Finland
Pregabalin is not a GABAA or GABAB receptor agonist.
A woman feeling stress
Chemical structures of GABA, pregabalin and two other gabapentinoids, gabapentin and phenibut.
The location of the nine paired tender points that comprise the 1990 American College of Rheumatology criteria for fibromyalgia
Widespread pain index (WPI) areas
Stress and trauma are strongly linked to fibromyalgia

Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal and generalized anxiety disorder (GAD).

- Pregabalin

The medications duloxetine, milnacipran, or pregabalin have been approved by the US Food and Drug Administration (FDA) for the management of fibromyalgia.

- Fibromyalgia
The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia

2 related topics with Alpha

Overall
Gate control theory of pain

Neuropathic pain

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Pain caused by damage or disease affecting the somatosensory system.

Pain caused by damage or disease affecting the somatosensory system.

Gate control theory of pain
Microglia (identified by alpha-coronin1a), and neurons in culture. Microglia are proposed to release molecules that alter the excitability of neurons.

First line treatments are certain antidepressants (tricyclic antidepressants and serotonin–norepinephrine reuptake inhibitors), anticonvulsants (pregabalin and gabapentin).

Gabapentin may reduce symptoms associated with neuropathic pain or fibromyalgia in some people.

Chemical structure of morphine, the prototypical opioid.

Opioid

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Opioids are substances that act on opioid receptors to produce morphine-like effects.

Opioids are substances that act on opioid receptors to produce morphine-like effects.

Chemical structure of morphine, the prototypical opioid.
US. Top line represents the number of benzodiazepine deaths that also involved opioids. Bottom line represents benzodiazepine deaths that did not involve opioids.
Locants of the morphine molecule
INTA: selective agonist of KOR-DOR and KOR-MOR heteromers. Does not recruit β-arrestin II. Antinociceptive devoid of aversion, tolerance, and dependence in mice.
A sample of raw opium
US yearly deaths from all opioid drugs. Included in this number are opioid analgesics, along with heroin and illicit .<ref name=NIDA-deaths/>
US yearly deaths involving other, predominately Fentanyl.<ref name=NIDA-deaths/>
US yearly deaths involving prescription opioids. is a category dominated by illegally acquired fentanyl, and has been excluded.<ref name=NIDA-deaths>Overdose Death Rates. By National Institute on Drug Abuse (NIDA).</ref>
US yearly overdose deaths involving heroin.<ref name=NIDA-deaths/>

Guidelines have suggested that the risk of opioids is likely greater than their benefits when used for most non-cancer chronic conditions including headaches, back pain, and fibromyalgia.

Anticonvulsants such as gabapentin or pregabalin