A report on Fibromyalgia

The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia
A woman feeling stress
The location of the nine paired tender points that comprise the 1990 American College of Rheumatology criteria for fibromyalgia
Widespread pain index (WPI) areas
Stress and trauma are strongly linked to fibromyalgia

Medical condition defined by the presence of chronic widespread pain, fatigue, waking unrefreshed, cognitive symptoms, lower abdominal pain or cramps, and depression.

- Fibromyalgia
The location of the 19 pain areas for the Widespread Pain Index of fibromyalgia

40 related topics with Alpha

Overall
Generic tramadol HCl tablets marketed by Amneal Pharmaceuticals

Tramadol

2 links

Opioid pain medication used to treat moderate to moderately severe pain.

Opioid pain medication used to treat moderate to moderately severe pain.

Generic tramadol HCl tablets marketed by Amneal Pharmaceuticals
Tramadol HCl for injection
Foil pack of 10 Utracet tablets
Main side effects of tramadol: Red color denotes more serious effects, requiring immediate contact with health provider.
Desmetramadol.

There is moderate evidence for use as a second-line treatment for fibromyalgia but it is not FDA approved for this use; however, its use is approved for treatment of fibromyalgia as a secondary painkiller by the NHS.

Individual with EDS displaying skin hyperelasticity

Ehlers–Danlos syndromes

4 links

Ehlers–Danlos syndromes (EDS) are a group of thirteen genetic connective-tissue disorders that are in the current classification, with a fourteenth type discovered in 2018.

Ehlers–Danlos syndromes (EDS) are a group of thirteen genetic connective-tissue disorders that are in the current classification, with a fourteenth type discovered in 2018.

Individual with EDS displaying skin hyperelasticity
Individual with EDS displaying skin hyperelasticity
The collagen fibril and EDS: (a) Normal collagen fibrils are of uniform size and spacing. Fibrils from a person with dermatosparaxis (b) show dramatic alterations in fibril morphology with severe effects on the tensile strength of connective tissues. A person with classical EDS (c) shows composite fibrils. Fibrils from a TNX-deficient person (d) are uniform in size and no composite fibrils are seen. TNX-null (e) fibrils are less densely packed and not as well aligned to neighboring fibrils.
Stevie Boebi and Annie Elainey, who have EDS, standing with walking aids on the red carpet.
Pageant contestant Victoria Graham has EDS.
Individual with EDS showing hypermobile fingers, including the "swan-neck" malformation on the 2nd–5th digits, and a hypermobile thumb
Individual with EDS displaying hypermobile thumb
Individual with EDS displaying hypermobile metacarpophalangeal joints
Kyphoscoliosis of the back of someone with kyphoscoliosis EDS
Severe joint hypermobility in a girl with EDS arthrochalasia type
Atrophic scar in a case of EDS
Translucent skin in vascular EDS
Individual with EDS displaying skin hyperelasticity
Piezogenic papules on the heel of an individual with hypermobile EDS
Skin hyperelasticity in the wrist
Gorlin's sign in a case of EDS
Keratoglobus in a case of EDS with brittle cornea syndrome
EDS in a dog
Same dog with EDS
EDS in the same dog showing an atrophic scar

People are commonly misdiagnosed with fibromyalgia, bleeding disorders, or other disorders that can mimic EDS symptoms.

Non-celiac gluten sensitivity

1 links

Removed from the diet, and celiac disease and wheat allergy have been excluded".

Removed from the diet, and celiac disease and wheat allergy have been excluded".

As of 2019, reviews have concluded that although FODMAPs may play a role in NCGS, they explain only certain gastrointestinal symptoms, such as bloating, but not the extra-digestive symptoms that people with NCGS may develop, such as neurological disorders, fibromyalgia, psychological disturbances, and dermatitis.

Temporomandibular joint

Temporomandibular joint dysfunction

0 links

Umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).

Umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).

Temporomandibular joint
Modern digitalised panoramic X-ray devices are capable to take TMJ images, which provides information about articular fossa and condyle.
A lower, full coverage occlusal splint after 8 years in use.
An upper, full coverage occlusal splint.
Left medial and lateral pterygoid muscles
Left temporalis muscle
Left masseter muscle (red highlight)

It is hypothesized that there is a great deal of similarity between TMD and other pain syndromes like fibromyalgia, irritable bowel syndrome, interstitial cystitis, headache, chronic lower back pain and chronic neck pain.

Cold sensitivity

0 links

Unusual discomfort felt by some people when in a cool environment.

Unusual discomfort felt by some people when in a cool environment.

Cold sensitivity may be a symptom of hypothyroidism, anemia, fibromyalgia or vasoconstriction.

Fibromyalgia is the classic example of nociplastic pain, being diagnosed when pain is felt in four different quadrants of the body using measures such as the Widespread Pain Index shown

Nociplastic pain

0 links

Type of pain which is mechanically different from the normal nociceptive pain caused by inflammation and tissue damage or the neuropathic pain which results from nerve damage.

Type of pain which is mechanically different from the normal nociceptive pain caused by inflammation and tissue damage or the neuropathic pain which results from nerve damage.

Fibromyalgia is the classic example of nociplastic pain, being diagnosed when pain is felt in four different quadrants of the body using measures such as the Widespread Pain Index shown

This type of pain typically arises in some chronic pain conditions, with the archetypal condition being fibromyalgia.

The autonomic nervous system

Dysautonomia

1 links

Condition in which the autonomic nervous system does not work properly.

Condition in which the autonomic nervous system does not work properly.

The autonomic nervous system
Vincristine
Valsalva maneuver
The H2 receptor antagonist, Cimetidine

In the sympathetic nervous system (SNS), predominant dysautonomia is common along with fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis, raising the possibility that such dysautonomia could be their common clustering underlying pathogenesis.

Cyclobenzaprine

1 links

Medication used for muscle spasms from musculoskeletal conditions of sudden onset.

Medication used for muscle spasms from musculoskeletal conditions of sudden onset.

Cyclobenzaprine 10mg tablets

A 2004 review found benefit for fibromyalgia symptoms, with a reported number needed to treat of 4.8 (meaning that 1 person out of every 4.8 benefits from treatment) for pain reduction, but no change in fatigue or tender points.

Schematic overview of the classes of stresses that plants are exposed to

Stress (biology)

1 links

Organism's response to a stressor such as an environmental condition.

Organism's response to a stressor such as an environmental condition.

Schematic overview of the classes of stresses that plants are exposed to
Neuro-hormonal response to stress
A diagram of the General Adaptation Syndrome model.

Stress may contribute to various disorders, such as fibromyalgia, chronic fatigue syndrome, depression, and functional somatic syndromes.

Small fiber peripheral neuropathy

1 links

Type of peripheral neuropathy that occurs from damage to the small unmyelinated and myelinated peripheral nerve fibers.

Type of peripheral neuropathy that occurs from damage to the small unmyelinated and myelinated peripheral nerve fibers.

Other notable studies have shown a link between erythromelalgia, fibromyalgia, and Ehlers–Danlos Syndrome.