Fordyce spots

Not to be confused with angiokeratoma of Fordyce or Fox-Fordyce diseasewikipedia
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Sebaceous gland

sebumsebaceous glandssebaceous
Fordyce spots (also termed Fordyce granules) are visible sebaceous glands that are present in most individuals.
Fordyce spots are ectopic (misplaced) sebaceous glands found usually on the lips, gums and inner cheeks, and genitals.

Vermilion border

vermillion bordervermilion
They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face. The most common site is along the line between the vermilion border and the oral mucosa of the upper lip, or on the buccal mucosa (inside the cheeks) in the commissural region, often bilaterally.
2) This epithelium contains eleidin which is transparent and the blood vessels are near the surface of the papillary layer, revealing the "red blood cell" color. At the angles of the mouth, there are sebaceous glands, without hair follicles, which are called Fordyce's spots.

Oral mucosa

buccal mucosaalveolar mucosabuccal membrane
The most common site is along the line between the vermilion border and the oral mucosa of the upper lip, or on the buccal mucosa (inside the cheeks) in the commissural region, often bilaterally.
A variable number of Fordyce spots or granules are scattered throughout the nonkeratinized tissue.

John Addison Fordyce

Fordyce
They are named after an American dermatologist, John Addison Fordyce.
John Addison Fordyce (born 16 February 1858 in Guernsey County, Ohio, died on 4 June 1925 in New York City) was an American dermatologist, whose name is associated with Fordyce's spot, (also known as Fordyce's disease or Fordyce's lesion), Angiokeratoma of Fordyce, Brooke–Fordyce trichoepithelioma, and Fox–Fordyce disease.

Hirsuties coronae glandis

pearly penile papuleshirsuties papillaris genitalis
On the foreskin they are called Tyson's glands, not to be confused with hirsuties coronae glandis.
Fordyce spots

Sex organ

genitaliagenitalsgenital
They appear on the genitals and/or on the face and in the mouth.

Penis

peniledickcock
They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face.

Labia

interlabial sulcilabiumbeef curtains
They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face.

Lip

upper liplower liplips
They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face.

Face

human facefacialfacial feature
They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face.

Sexually transmitted infection

venereal diseasesexually transmitted diseasesexually transmitted diseases
Persons with this condition sometimes consult a dermatologist because they are worried they may have a sexually transmitted disease (especially genital warts) or some form of cancer.

Genital wart

genital wartscondylomacondylomata acuminata
Persons with this condition sometimes consult a dermatologist because they are worried they may have a sexually transmitted disease (especially genital warts) or some form of cancer.

Cancer

cancersmalignanciescancerous
Persons with this condition sometimes consult a dermatologist because they are worried they may have a sexually transmitted disease (especially genital warts) or some form of cancer.

Sebaceous hyperplasia

hyperplasia
Occasionally, several adjacent glands will coalesce into a larger cauliflower-like cluster similar to sebaceous hyperplasia of the skin. In such an instance, it may be difficult to determine whether or not to diagnose the lesion as sebaceous hyperplasia or sebaceous adenoma.

Sebaceous adenoma

sebaceous gland tumours
In such an instance, it may be difficult to determine whether or not to diagnose the lesion as sebaceous hyperplasia or sebaceous adenoma.

Sebaceous carcinoma

sebaceous tumorsebaceous tumors
Sebaceous carcinoma of the oral cavity has been reported, presumably arising from Fordyce granules or hyperplastic foci of sebaceous glands.

Hair follicle

hair folliclesfolliclefollicles
Normally, sebaceous glands are only found in association with a hair follicle.

Rheumatism

rheumaticrheumatic diseasesrheumatic disease
They appear to be more obvious in people with oily skin types, with some rheumatic disorders, and in hereditary nonpolyposis colorectal cancer.

Hereditary nonpolyposis colorectal cancer

Lynch syndromehereditary nonpolyposis colon cancercolorectal neoplasms, hereditary nonpolyposis
They appear to be more obvious in people with oily skin types, with some rheumatic disorders, and in hereditary nonpolyposis colorectal cancer.

Gums

gingivagumgingival
In the latter, the most common site for Fordyce spots is the lower gingiva (gums) and vestibular mucosa.

Epidermoid cyst

epidermoid cystsepidermal cystepidermoid
Large numbers of lobules coalescing into a definitely elevated mass may be called benign sebaceous hyperplasia, and occasional small keratin-filled pseudocysts may be seen and must be differentiated from epidermoid cyst or dermoid cyst with sebaceous adnexa.

Dermoid cyst

dermoidbenign mature cystic teratomaDermoid cysts
Large numbers of lobules coalescing into a definitely elevated mass may be called benign sebaceous hyperplasia, and occasional small keratin-filled pseudocysts may be seen and must be differentiated from epidermoid cyst or dermoid cyst with sebaceous adnexa.

Sebaceous lymphadenoma

The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous lymphadenoma and [[sebaceous and their malignant counterparts sebaceous lymphadenocarcinoma and sebaceous carcinoma.

Cytoplasm

cytoplasmiccytosolicintracytoplasmic
Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm

Human skin

skinoily skinskin aging
Sebaceous glands are normal structures of the skin but may also be found ectopically in the mouth, where they are referred to as oral Fordyce granules or ectopic sebaceous glands.