Genistein

Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen.wikipedia
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Daidzein

3′-hydroxydaidzein
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs like Kwao Krua (Pueraria mirifica) and Kudzu (Pueraria lobata).

Isoflavone

isoflavones
Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen. Besides functioning as antioxidant and anthelmintic, many isoflavones have been shown to interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen.
Soybeans are the most common source of isoflavones in human food; the major isoflavones in soybean are genistein and daidzein.

Kudzu

kudzu vineK''akkontō
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
Kudzu contains isoflavones, including puerarin (about 60% of the total isoflavones), daidzein, daidzin (structurally related to genistein), mirificin, and salvianolic acid, among numerous others identified.

Maackia amurensis

Maackia amurensis subsp. Buergeri
It can also be found in Maackia amurensis cell cultures.
The isoflavones daidzein, retusin, genistein and formononetin and the pterocarpans maackiain and medicarpin can be found in ''M.

Flemingia vestita

Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
It is rich in bioactive isoflavones such as genistein, daidzein, formononetin and pseudobaptigenin.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
Yet another possible and probable role of protein tyrosine kinase is that in the event of circulatory failure and organ dysfunction caused by endotoxin in rats, where the effects of inhibitors tyrphostin and genistein are involved with protein tyrosine kinase.

Genista tinctoria

dyer's greenweeddyer’s greenweeddyer's broom
It was first isolated in 1899 from the dyer's broom, Genista tinctoria; hence, the chemical name.
It was from this plant that the isoflavone genistein was first isolated in 1899; hence the name of the chemical compound.

Estrogen receptor

estrogenERestrogen receptors
Besides functioning as antioxidant and anthelmintic, many isoflavones have been shown to interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen.

Flemingia macrophylla

F. macrophylla
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
Genistein, 5, 7,3’, 4’-tetrahydroxyisoflavone, 5, 7, 4’-trihydroxyisoflavone-7-O-β-D-glucopyranoside, 5, 7,4’-trihydroxy-8,3’-diprenylflavanone, 5, 7,4’-trihydroxy-6-prenylisoflavone, flemichin D, lespedezaflavanone A and ouratea-catechin are isolated from the root, in which genistein and its isoflavones analogs are the main constituents.

Soybean

soysoybeansGlycine max
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
Soybeans contain the isoflavones, genistein and daidzein, which are phytoestrogen compounds under preliminary research in cardiovascular diseases and numerous other diseases.

Phytoestrogen

phytoestrogensestrogen-like compoundsphytoestorgenic
Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen.
A Cochrane Review of the use of phytoestrogens to relieve the vasomotor symptoms of menopause (hot flashes) stated that there was no conclusive evidence to suggest any benefit to their use, although genistein effects should be further investigated.

Medicinal plants

medicinal plantmedicinal herbmedicinal herbs
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.
Some important phytochemicals, including curcumin, epigallocatechin gallate, genistein and resveratrol are pan-assay interference compounds, meaning that in vitro studies of their activity often provide unreliable data.

Estrogen

oestrogenestrogensestrogenic
Besides functioning as antioxidant and anthelmintic, many isoflavones have been shown to interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen.

Estrogen receptor alpha

ERαESR1estrogen receptor α
However, genistein shows much higher affinity toward estrogen receptor β than toward estrogen receptor α.

Angiogenesis inhibitor

anti-angiogenicantiangiogenicangiogenesis inhibitors
Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen.

Genistin

It was first isolated in 1931 from the 90% methanol extract of a soybean meal, when it was found that hydrolysis with hydrochloric acid produced 1 mole each of genistein and glucose.

Topoisomerase inhibitor

inhibitorsDNA topoisomerase II inhibitorsinhibitor
Genistein was, among other flavonoids, found to be a strong topoisomerase inhibitor, similarly to some chemotherapeutic anticancer drugs ex. etoposide and doxorubicin.
EGCG, genistein, quercetin, resveratrol) possess strong topoisomerase inhibitory properties affecting both types of enzymes.

Flavonoid

flavonoidsflavanoidbioflavonoid
Genistein was, among other flavonoids, found to be a strong topoisomerase inhibitor, similarly to some chemotherapeutic anticancer drugs ex. etoposide and doxorubicin.

Equol

(S)-EquolS-Equol
While many more bacteria are involved in the related intermediate process of (S)-equol production, such as conversion of daidzin to daidzein, or genistein to 5-Hydroxy-equol, the bacteria that can produce a complete conversion of daidzein to (S)-equol, are the following:

Estrogen receptor beta

ERβESR2ER-β
However, genistein shows much higher affinity toward estrogen receptor β than toward estrogen receptor α.

Sanfilippo syndrome

mucopolysaccharidosis IIIMPS III-AMPS III-B
Genistein decreases pathological accumulation of glycosaminoglycans in Sanfilippo syndrome.
The flavonoid genistein decreases the accumulation of GAGs.

Lupinus

lupinlupinelupins
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.

Vicia faba

fava beansbroad beanbroad beans
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.

Psoralea

Hallialanceleaf breadrootlemon scurf-pea
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.

Coffee

coffee beansblack coffeegourmet coffee
Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee.