Gluten challenge test

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The gluten challenge test is a medical test in which gluten-containing foods are consumed and (re-)occurrence of symptoms is observed afterwards to determine whether and how much a person reacts to these foods.wikipedia
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Medical test

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The gluten challenge test is a medical test in which gluten-containing foods are consumed and (re-)occurrence of symptoms is observed afterwards to determine whether and how much a person reacts to these foods.

Coeliac disease

celiac diseaseceliac spruecoeliac
Gluten challenge protocols have significant limitations because a symptomatic relapse generally precedes the onset of a serological and histological relapse, and therefore becomes unacceptable for most patients. Currently, gluten challenge is no longer required to confirm the diagnosis in patients with intestinal lesions compatible with coeliac disease and a positive response to a gluten-free diet. For people eating a gluten-free diet who are unable to perform an oral gluten challenge, an alternative to identify a possible celiac disease is an in vitro gliadin challenge of small bowel biopsies, but this test is available only at selected specialized tertiary-care centers.
For those who have already started on a gluten-free diet, it may be necessary to perform a rechallenge with some gluten-containing food in one meal a day over 6 weeks before repeating the investigations.

Non-celiac gluten sensitivity

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A recently proposed criteria to non-coeliac gluten sensitivity diagnosis concludes that an improvement of gastrointestinal symptoms and extra-intestinal manifestations higher than 50% with a gluten-free diet (GFD), assessed through a rating scale, may confirm the clinical diagnosis of non-coeliac gluten sensitivity.
To exclude a placebo effect, a double-blind placebo-controlled gluten challenge is a useful tool, although it is expensive and complicated for routine clinical use, and so is usually performed in research studies.

Gluten

glutinouswheat glutenglutin
The gluten challenge test is a medical test in which gluten-containing foods are consumed and (re-)occurrence of symptoms is observed afterwards to determine whether and how much a person reacts to these foods.

Gluten-related disorders

gluten intolerancegluten sensitivityGluten intolerant
The test may be performed in people with suspected gluten-related disorders in very specific occasions and under medical supervision, for example in people who had started a gluten-free diet without performing duodenal biopsy.

Puberty

pubescentpubescencesexual development
Gluten challenge is discouraged before the age of 5 years and during pubertal growth.

Gluten-free diet

gluten-freegluten freegluten free diet
A recently proposed criteria to non-coeliac gluten sensitivity diagnosis concludes that an improvement of gastrointestinal symptoms and extra-intestinal manifestations higher than 50% with a gluten-free diet (GFD), assessed through a rating scale, may confirm the clinical diagnosis of non-coeliac gluten sensitivity. Currently, gluten challenge is no longer required to confirm the diagnosis in patients with intestinal lesions compatible with coeliac disease and a positive response to a gluten-free diet. For people eating a gluten-free diet who are unable to perform an oral gluten challenge, an alternative to identify a possible celiac disease is an in vitro gliadin challenge of small bowel biopsies, but this test is available only at selected specialized tertiary-care centers.

Placebo

placebo effectplacebosplacebo studies
To exclude a placebo effect, a double-blind placebo-controlled gluten challenge is a useful tool, although it is expensive and complicated in routine clinical ground, and therefore, is only performed in research studies.

Placebo-controlled study

placebo-controlledplacebo-controlled studiesplacebo
To exclude a placebo effect, a double-blind placebo-controlled gluten challenge is a useful tool, although it is expensive and complicated in routine clinical ground, and therefore, is only performed in research studies.

Clinical trial

clinical trialsclinical studiesclinical study
The test is also frequently used in clinical trials, for example for assessing the efficacy of novel drugs for patients with coeliac disease.

Randomized controlled trial

randomized controlled trialsrandomized clinical trialrandomized control trial
A double-blind placebo-controlled gluten challenge can be performed by means of capsules containing gluten powder (or wheat powder) or a placebo, respectively, although it is expensive and complicated in routine clinical ground, and therefore, is only performed in research studies.

In vitro

in-vitrolaboratoryartificially
For people eating a gluten-free diet who are unable to perform an oral gluten challenge, an alternative to identify a possible celiac disease is an in vitro gliadin challenge of small bowel biopsies, but this test is available only at selected specialized tertiary-care centers.

Gliadin

For people eating a gluten-free diet who are unable to perform an oral gluten challenge, an alternative to identify a possible celiac disease is an in vitro gliadin challenge of small bowel biopsies, but this test is available only at selected specialized tertiary-care centers.

Dermatitis herpetiformis

Duhring's diseaseskin condition
As of January 4, 2019 the vaccine has entered phase 2 trials to assess the efficacy of the vaccine in individuals with celiac disease who are given a gluten-challenge test.