Gluten immunochemistry

Immunochemistry of gluteninnate response to gliadinthis pageα2-gliadinα2-gliadin fragment
The immunochemistry of Triticeae glutens is important in several inflammatory diseases.wikipedia
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Gliadin

In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase.
Immunochemistry of gluten

Coeliac disease

celiac diseasecoeliacceliac
In addition, innate immunity to IRP peptide is involved in coeliac disease, dermatitis herpetiformis and possibly juvenile diabetes.
This innate response to gliadin results in immune-system signalling that attracts inflammatory cells and increases the release of inflammatory chemicals.

Wheat allergy

Wheatallergic to wheatbaker's asthma
In wheat allergy, the response pathways are mediated through IgE against other wheat proteins and other forms of gliadin.
Gluten immunochemistry

Larazotide

larazotide acetate
In celiac disease, one pathway that allows fragments of gliadin protein to get past the intestinal epithelium and subsequently trigger an immune response begins with binding of indigestible gliadin fragments to the chemokine CXC motif receptor 3 (CXCR3) on the luminal side of the intestinal epithelium (see this page).

Chaitan Khosla

His group play a large role in identifying the role of the α2-gliadin fragment in immune responses.

Enteropathy-associated T-cell lymphoma

enteropathy-associated T cell lymphomalymphoma (EATL)
(See Coeliac Disease, HLA-DQ, HLA DR3-DQ2) A DQ isoform that appears to be responsible for EATL in the overwhelming number of cases is highly effective at presenting a proteolytically protected region of α2-gliadin to T-cells, constant over-stimulation of T-cell eventually results in neoplastic growth.

Immunochemistry

Immunochemicalimmunochemistimmunochemical analysis
The immunochemistry of Triticeae glutens is important in several inflammatory diseases.

Triticeae glutens

Triticeae'' glutensglutenglutens
The immunochemistry of Triticeae glutens is important in several inflammatory diseases.

MHC class II

class IIHLA class IIMHC II
It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition.

MHC class I

class Iclass I MHCMHC I
It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition.

Antibody

antibodiesimmunoglobulinimmunoglobulins
In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase. It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition. Innate immunity to gluten refers to an immune response that works independently of T-cell receptor or antibody recognition of the 'innate' peptide.

Gluten

glutinouswheat glutenglutin
The responses to gluten proteins and polypeptide regions differs according to the type of gluten sensitivity. Innate immunity to gluten refers to an immune response that works independently of T-cell receptor or antibody recognition of the 'innate' peptide.

Protein

proteinsprotein synthesisproteinaceous
The responses to gluten proteins and polypeptide regions differs according to the type of gluten sensitivity.

Human leukocyte antigen

HLAhuman leukocyte antigenshuman leucocyte antigen
The response is also dependent on the genetic makeup of the human leukocyte antigen genes.

Innate immune system

innate immunityinnateinnate immune response
In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase. Innate immunity to gluten refers to an immune response that works independently of T-cell receptor or antibody recognition of the 'innate' peptide.

HLA-DQ

DQDQ heterodimerDQ2
In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase. It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition.

Transglutaminase

transglutaminasesTGMtransglutaminases (TGs
In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase.

Immunoglobulin E

IgEImmunoglobulin E (IgE)immunoglobulin epsilon-chains
In wheat allergy, the response pathways are mediated through IgE against other wheat proteins and other forms of gliadin.

Immune response

immunological responseimmuneadaptative immune response
Innate immunity to gluten refers to an immune response that works independently of T-cell receptor or antibody recognition of the 'innate' peptide.

T-cell receptor

TCRT cell receptorT cell receptors
Innate immunity to gluten refers to an immune response that works independently of T-cell receptor or antibody recognition of the 'innate' peptide.

Enterocyte

enterocytescellsintestinal cells
In bypassing these filters gliadin alters the normal behavior of both digestive cells, called enterocytes or epithelial cells, and lymphocytes.

Interleukin 15

IL-15interleukin-15IL15
Once inside, α-9 gliadin 31-55 shows the ability to activate undifferentiated immune cells that then proliferate and also produce inflammatory cytokines, notably interleukin 15 (IL-15).

Peptide

polypeptidepeptidespolypeptides
The responses to gluten proteins and polypeptide regions differs according to the type of gluten sensitivity.