Goblet cell

goblet cellsglandular epithelial cellsgobletgoblet cell metaplasiamucous cells
Goblet cells are simple columnar goblet shaped like epithelial cells that secrete gel-forming mucins, like mucin MUC5AC.wikipedia
163 Related Articles

Airway basal cell

basal cells
Biased differentiation of airway basal cells in the respiratory epithelium, into goblet cells plays a key role in the excessive mucus production, known as mucus hypersecretion seen in many respiratory diseases, including chronic bronchitis, and asthma.
Basal cells are the stem cells or progenitors of the airway epithelium and can differentiate to replenish all of the epithelial cells including the ciliated cells, and secretory goblet cells.

Trachea

windpipetrachealtracheae
They are found inside the trachea, bronchi, and larger bronchioles in the respiratory tract, small intestines, the large intestine, and conjunctiva in the upper eyelid.
It is lined with an epithelium that has goblet cells which produce protective mucins (see Respiratory epithelium).

Conjunctiva

conjunctivalbulbar conjunctivaconjunctival sac
They are found inside the trachea, bronchi, and larger bronchioles in the respiratory tract, small intestines, the large intestine, and conjunctiva in the upper eyelid. In the conjunctiva goblet cells are a source of mucin in tears and they also secrete different types of mucins onto the ocular surface.
It is composed of unkeratinized, stratified squamous epithelium with goblet cells, and stratified columnar epithelium.

Small intestine

small bowelsmall intestinessmall
They are found inside the trachea, bronchi, and larger bronchioles in the respiratory tract, small intestines, the large intestine, and conjunctiva in the upper eyelid.

Respiratory epithelium

bronchial epithelial cellsbronchiolar epitheliumbrush cell
Biased differentiation of airway basal cells in the respiratory epithelium, into goblet cells plays a key role in the excessive mucus production, known as mucus hypersecretion seen in many respiratory diseases, including chronic bronchitis, and asthma.
The cells in the respiratory epithelium are of four main types: a) ciliated cells, b) goblet cells, c) club cells, and d) airway basal cells.

Tears

lacrimationteartear film
In the conjunctiva goblet cells are a source of mucin in tears and they also secrete different types of mucins onto the ocular surface.

Bronchus

bronchibronchialbronchial tubes
They are found inside the trachea, bronchi, and larger bronchioles in the respiratory tract, small intestines, the large intestine, and conjunctiva in the upper eyelid.
The epithelium in the main bronchi contains goblet cells, which are glandular, modified simple columnar epithelial cells that produce mucins, the main component of mucus.

Mucus

mucousmucinousslime
Biased differentiation of airway basal cells in the respiratory epithelium, into goblet cells plays a key role in the excessive mucus production, known as mucus hypersecretion seen in many respiratory diseases, including chronic bronchitis, and asthma.
It is a viscous colloid containing inorganic salts, antimicrobial enzymes (such as lysozymes), immunoglobulins, and glycoproteins such as lactoferrin and mucins, which are produced by goblet cells in the mucous membranes and submucosal glands.

Bronchitis

chronic bronchitisbronchialbronchial affection
Biased differentiation of airway basal cells in the respiratory epithelium, into goblet cells plays a key role in the excessive mucus production, known as mucus hypersecretion seen in many respiratory diseases, including chronic bronchitis, and asthma.
The excess mucus is produced by goblet cells and enlarged submucosal glands in response to long-term irritation.

Respiratory tract

airwayupper respiratory tractlower respiratory tract
Goblet cells are found scattered among the epithelial lining of organs, such as the intestinal and respiratory tracts. Distinct forms of mucin are produced in different organs: while MUC2 is prevalent in the intestine, MUC5AC and MUC5B are the main forms found in the human airway.
There are glands and mucus produced by goblet cells in parts, as well as smooth muscle, elastin or cartilage.

Bronchiole

bronchiolesbronchialrespiratory bronchiole
They are found inside the trachea, bronchi, and larger bronchioles in the respiratory tract, small intestines, the large intestine, and conjunctiva in the upper eyelid.
Terminal bronchioles contain a limited number of ciliated cells and no goblet cells.

Mucin 2

MUC2
Distinct forms of mucin are produced in different organs: while MUC2 is prevalent in the intestine, MUC5AC and MUC5B are the main forms found in the human airway.
Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine.

Foveolar cell

foveolaeMucous neck and pit cellsmucous neck cell
There are other cells that secrete mucus (such as the foveolar cells of the stomach) but these are distinguished histologically from goblet cells.
The mucus-secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells, another type of mucus-secreting cell.

Barrett's esophagus

Barrett's oesophagusBarrett’s esophagusBarrett esophagus
Goblet cells may be an indication of metaplasia, such as in Barrett's esophagus.
Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from normal stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine, and large intestine.

Interleukin 13

IL-13interleukin-13IL13
Goblet cell metaplasia in allergic asthma is due to the action of the cytokine IL-13.
Interleukin-13 has a critical role in the Goblet cell metaplasia.

Intestinal villus

villiintestinal villivillus
Enterocytes, along with goblet cells, represent the principal cell types of the epithelium of the villi in the small intestine.

Epithelium

epithelialepithelial cellsepithelial cell
Goblet cells are found scattered among the epithelial lining of organs, such as the intestinal and respiratory tracts. Goblet cells are simple columnar goblet shaped like epithelial cells that secrete gel-forming mucins, like mucin MUC5AC.

Mucin

mucinsSialomucinMUC12
Goblet cells are simple columnar goblet shaped like epithelial cells that secrete gel-forming mucins, like mucin MUC5AC.

Merocrine

eccrineeccrine ductsmerocrine secretion
The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress.

Apocrine

apocrine glandapocrine glands
The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress.

Chalice

gobletchalicesgoblets
The term goblet refers to the cell's goblet-like shape.

Microvillus

microvillimicovillimicrovilli-covered
The apical plasma membrane projects short microvilli to give an increased surface area for secretion.

Asthma

asthma attackbronchial asthmaasthmatic
Biased differentiation of airway basal cells in the respiratory epithelium, into goblet cells plays a key role in the excessive mucus production, known as mucus hypersecretion seen in many respiratory diseases, including chronic bronchitis, and asthma.