ITGAE

CD103AECD103 + αeβ7
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.wikipedia
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Integrin

integrinsintegrin receptorintegrin alpha1
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.

Integrin beta 7

ITGB7β7 subunitalpha 4 beta 7 integrin
CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name.
It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor αβ, or with ITGAE (CD103) to form αβ.

Intraepithelial lymphocyte

intraepithelial lymphocytesintra-epithelial lymphocytes
CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs).
In both humans and mice IELs express higher levels of CD103, activation marker CD69, granzyme B and perforin cytolytic granules.

Enteropathy-associated T-cell lymphoma

Enteropathy type T-cell lymphomaenteropathy-associated T cell lymphomalymphoma (EATL)
It is useful in identifying hairy cell leukemia which is positive for this marker in contrast to most other hematologic malignancies which are negative for CD103 except enteropathy-associated T cell lymphoma.
These cells also express CD103 and, frequently, CD30.

Hairy cell leukemia

Hairy cell leukaemialeukemia, hairy cellHairy-cell leukemia
It is useful in identifying hairy cell leukemia which is positive for this marker in contrast to most other hematologic malignancies which are negative for CD103 except enteropathy-associated T cell lymphoma.
The hairy cells are larger than normal and positive for CD19, CD20, CD22, CD11c, CD25, CD103, and FMC7.

Tissue-resident memory T cell

The main cell surface markers that has been associated with TRM in human tissues are CD69 and CD103.

Gene

genesnumber of genesgene sequence
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.

Integrin alpha 4

CD49dITGA4A4
Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).

Gamma delta T cell

γδ T cellsγδ T cellVγ9/Vδ2 T cells
CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs).

Regulatory T cell

regulatory T cellsTregTregs
CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs).

Lamina propria

mucosaThe lamina propria
It has also been reported on lamina propria T cells.

Dendritic cell

dendritic cellsmyeloid dendritic cellsdendritic
A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes, known as CD103 dendritic cells, also expresses this marker.

Mucous membrane

mucosamucous membranesmucosal
A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes, known as CD103 dendritic cells, also expresses this marker.

Mesenteric lymph nodes

mesentericmesenteric glands
A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes, known as CD103 dendritic cells, also expresses this marker.

CDH1 (gene)

E-cadherinCDH1CD324
The chief ligand for αEβ7 is E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells.

Cell adhesion molecule

adhesion moleculescell adhesion moleculesadhesion molecule
The chief ligand for αEβ7 is E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells.

Epithelium

epithelialepithelial cellsepithelial cell
The chief ligand for αEβ7 is E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells.

Autoimmune disease

autoimmune diseasesautoimmune disorderautoimmune
Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases.

CD4

CD4+CD4 + CD4 count
Tregs are defined as CD4 + /CD25 + /Foxp3 + cells.

IL2RA

CD25alpha chainCD25 +
Tregs are defined as CD4 + /CD25 + /Foxp3 + cells.

FOXP3

forkhead box protein 3FOXP3 (a transcription factor)
Tregs are defined as CD4 + /CD25 + /Foxp3 + cells.

Cluster of differentiation

CDC'''luster of '''D'''ifferentiationclusters of differentiation

Monoclonal B-cell lymphocytosis

monoclonal B-cell lymphocytosis (MBL)
Cases of non-CLL/SLL MBL in which the monoclonal B cells do not express CD5, CD23, CD10, or CD103 but strongly express CD79B and light chain Ig have been tentatively designated as having monoclonal B-cell lymphocytosis of the marginal zone (i.e. CBL-MZ).

Pancreatic islet macrophage

In terms of expression markers, islet macrophages are positive for; F4/80, CD11b, CD11c, MHC-II, CD64, CD68, LyzM (lysozyme), Cx3cr1 and are negative for; CD206 (mannose receptor), CD301, CD103.

List of human clusters of differentiation

antigens, differentiation, b-lymphocyteantigens, differentiation, myelomonocyticantigens, differentiation, t-lymphocyte