IgA nephropathy

Berger's diseaseBerger diseaseglomerulonephritis, igaIgA nephropathy 3IgA-nephropathy
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.wikipedia
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Hematuria

blood in the urinehaematuriabloody urine
The classic presentation for the non-aggressive form (in 40–50% of the cases) is episodic hematuria, which usually starts within a day or two of a non-specific upper respiratory tract infection (hence synpharyngitic), as opposed to post-streptococcal glomerulonephritis, which occurs some time (weeks) after initial infection.

Henoch–Schönlein purpura

Henoch-Schonlein purpuraIgA vasculitispurpura, schoenlein-henoch
There are other diseases associated with glomerular IgA deposits, the most common being IgA vasculitis (formerly known as Henoch–Schönlein purpura [HSP]), which is considered by many to be a systemic form of IgA nephropathy.
As with IgA nephropathy, serum levels of IgA are high in HSP and there are identical findings on renal biopsy; however, IgA nephropathy has a predilection for young adults while HSP is more predominant among children.

Proteinuria

protein in the urineproteinIsolated proteinuria
A smaller proportion (20-30%), usually the older population, have microscopic hematuria and proteinuria (less than 2 gram/day).

Microhematuria

microscopic hematuriaMicroscopic amounts of blood
The gross hematuria may resolve after a few days, though microscopic hematuria will persist, it is however more common with aggressive Berger's disease for gross hematuria to persist rather than microscopic hematuria.
While not dangerous in itself, it may be a symptom of kidney disease, such as IgA nephropathy or Sickle cell trait, which should be monitored by a doctor.

Glomerulonephritis

C3 glomerulonephritisglomerular nephritisglomerulonephritis, membranoproliferative
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.
IgA nephropathy, also known as Berger's disease, is the most common type of glomerulonephritis, and generally presents with isolated visible or occult hematuria, occasionally combined with low grade proteinuria, and rarely causes a nephritic syndrome characterised by protein in the urine, and visible blood in the urine.

Thin basement membrane disease

Benign familial hematuriaThin glomerular basement membrane disease
Other renal causes of isolated hematuria include thin basement membrane disease and Alport syndrome, the latter being a hereditary disease associated with hearing impairment and eye problems.
Thin basement membrane disease (TBMD, also known as benign familial hematuria and thin basement membrane nephropathy or TBMN) is, along with IgA nephropathy, the most common cause of hematuria without other symptoms.

Glomerulus (kidney)

glomerulusglomeruliglomerular
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.
Examples are diabetic kidney disease, glomerulonephritis, and IgA nephropathy.

Chronic kidney disease

chronic renal failureend-stage renal diseasechronic kidney failure
In general, the entry into chronic kidney failure is slow as compared to most other glomerulonephritides – occurring over a time scale of 30 years or more (in contrast to the 5 to 15 years in other glomerulonephritides), however in aggressive Berger's disease the time scale is within 5–10 years and often sooner.

Rapidly progressive glomerulonephritis

Rapidly progressing glomerulonephritiscrescentsglomerular crescent
These diseases include systemic lupus erythematosus, acute proliferative glomerulonephritis, Henoch–Schönlein purpura, and IgA nephropathy.

ACE inhibitor

ACE inhibitorsangiotensin converting enzyme inhibitorangiotensin-converting enzyme inhibitor
However, Angiotensin converting enzyme inhibitors and Angiotensin II receptor antagonists are favoured due to their anti-proteinuric effect.
The most compelling evidence for the treatment of nephropathy has been found: This combination therapy partially reversed the proteinuria and also exhibited a renoprotective effect in patients afflicted with diabetic nephropathy, and pediatric IgA nephropathy.

Immunoglobulin A

IgASecretory IgAIgA1
Primary IgA nephropathy is characterized by deposition of the IgA antibody in the glomerulus.
IgA nephropathy is caused by IgA deposits in the kidneys.

Kidney disease

renal diseasenephropathykidney damage
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.

Immune system

immuneimmune responseimmune function
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.

Inflammation

inflammatoryinflammatory responseinflamed
IgA nephropathy (IgAN), also known Berger's disease (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.

Liver

hepaticliver protein synthesislivers
Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart.

Skin

cutaneousskin cellanimal skin
Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart.

Heart

cardiachuman heartapex of the heart
Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart.

National Organization for Rare Disorders

National Organization for Rare DisorderNORD
IgA nephropathy is the most common glomerulonephritis worldwide; however, aggressive Berger's disease is on the NORD list of rare diseases.

Antibody

antibodiesimmunoglobulinimmunoglobulins
Primary IgA nephropathy is characterized by deposition of the IgA antibody in the glomerulus.

Purpura

purpuricFood-induced purpuraPurpura secondary to clotting disorders
IgA vasculitis presents with a characteristic purpuric skin rash, arthritis, and abdominal pain, and occurs more commonly in young adults (16–35 years old).

Arthritis

arthriticjoint inflammationarthritic changes
IgA vasculitis presents with a characteristic purpuric skin rash, arthritis, and abdominal pain, and occurs more commonly in young adults (16–35 years old).

Upper respiratory tract infection

upper respiratory infectionupper respiratory tract infectionsupper respiratory infections
The classic presentation for the non-aggressive form (in 40–50% of the cases) is episodic hematuria, which usually starts within a day or two of a non-specific upper respiratory tract infection (hence synpharyngitic), as opposed to post-streptococcal glomerulonephritis, which occurs some time (weeks) after initial infection.

Acute proliferative glomerulonephritis

post-streptococcal glomerulonephritispoststreptococcal glomerulonephritisPost-infectious glomerulonephritis
The classic presentation for the non-aggressive form (in 40–50% of the cases) is episodic hematuria, which usually starts within a day or two of a non-specific upper respiratory tract infection (hence synpharyngitic), as opposed to post-streptococcal glomerulonephritis, which occurs some time (weeks) after initial infection.

Loin

loinstenderloinLoin (also called lumbus)
With both aggressive and non-aggressive Berger's disease loin pain can also occur.

Acute kidney injury

acute renal failureacute kidney failureuremic poisoning
Renal function usually remains normal with non-aggressive Berger's disease, though rarely acute kidney failure may occur (see below).