Integrin-linked kinase

ILKILK1
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction.wikipedia
36 Related Articles

Signal transduction

signaling pathwayssignaling cascadesignal transduction pathways
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction.
Integrins lack kinase activity; hence, integrin-mediated signal transduction is achieved through a variety of intracellular protein kinases and adaptor molecules, the main coordinator being integrin-linked kinase.

High Affinity K+ transporter HAK5

HAK5
High Affinity Potassium uptake mediators such as HAK5 have also been found to be integral in the signaling of flg22.
The main kinase that works with this transporter is Intergrin- Linked Kinase 1 (ILK1).

LIMS1

LIMS3
LIMS1 has been shown to interact with Integrin-linked kinase and NCK2.

ILKAP

Enzyme

enzymologyenzymesenzymatic
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction.

Gene

genesnumber of genesgene sequence
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction.

Cell migration

migrationcell motilitymigrate
Since its discovery, ILK has been associated with multiple cellular functions including cell migration, proliferation, and adhesion.

Cell growth

proliferationcell proliferationgrowth
Since its discovery, ILK has been associated with multiple cellular functions including cell migration, proliferation, and adhesion.

Cell adhesion

adhesioncellular adhesioncell-cell adhesion
Since its discovery, ILK has been associated with multiple cellular functions including cell migration, proliferation, and adhesion.

Ankyrin

ankyrin repeatsANK2ankyrin repeats domain
The structure of ILK consists of three features: 5 ankyrin repeats in the N-terminus, Phosphoinositide binding motif and extreme N-terminus of kinase catalytic domain.

Phosphatidylinositol

phosphoinositidephosphoinositidesphosphatidyl inositol
The structure of ILK consists of three features: 5 ankyrin repeats in the N-terminus, Phosphoinositide binding motif and extreme N-terminus of kinase catalytic domain.

Kinase

kinaseskinase domainprotein kinase C
The structure of ILK consists of three features: 5 ankyrin repeats in the N-terminus, Phosphoinositide binding motif and extreme N-terminus of kinase catalytic domain.

Focal adhesion

focal adhesionsadhesion plaquesfocal-adhesion
In mammals ILK lacks catalytic activity but supports scaffolding protein functions for focal adhesions.

Extracellular matrix

ECMmatrixextracellular matrices
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins.

Integrin

integrinsintegrin receptorintegrin alpha1
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins.

Cytoplasm

cytoplasmiccytosolicintracytoplasmic
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins.

Centrosome

centrosomescentrosomalcentrosomal proteins
In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.

Spindle apparatus

mitotic spindlespindlemitotic apparatus
In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.

Protein–protein interaction

interactprotein-protein interactionsprotein-protein interaction
Integrin-linked kinase has been shown to interact with:

Pathogen-associated molecular pattern

PAMPspathogen-associated molecular patternsPAMP
PAMPs functions by activating regulators of bacterial pathogen alert system.

Calmodulin

CaMcalcium/calmodulincalcium/calmodulin (Ca2+/CaM)
While CLM9 primarily regulates Ca 2+ it is linked to a yet identified K + /Ca 2+ influx channel.

Reactive oxygen species

ROSreactive oxygenoxygen radicals
ILK1 increases PAMP response and basal immunity through phosphorylation of MPK3 and MPK6 and operates independently in reactive oxygen species (ROS) production.

Biochemical cascade

cascadecascadescascading
In order to function, integrins have to form complexes with ILK and Fak proteins.