Interleukin 1 beta

IL-1βinterleukin-1βIL1Binterleukin-1 betainterleukin 1βIL-1betaIL-1βIL-1BIL1-βinterleukin 1-beta
Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.wikipedia
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Caspase 1

caspase-1CASP1Caspase-1/Interleukin-1 converting enzyme
IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursor s of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.

IL1A

IL-1αinterleukin-1 alphaIL-1 alpha
There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene).
It was not until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta.

Cryopyrin-associated periodic syndrome

CAPSCryopyrin-Associated Periodic Syndromes (CAPS)
Increased production of IL-1β causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as Cryopyrin-Associated Periodic Syndromes (CAPS), due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1B. Canakinumab is a human monoclonal antibody targeted at IL-1B, and approved in many countries for treatment of cryopyrin-associated periodic syndromes.
Cryopyrin-associated periodic syndrome is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin 1β-mediated systemic inflammation and clinical symptoms involving skin, joints, central nervous system, and eyes.

Periodic fever syndrome

autoinflammatoryautoinflammatory diseaseAutoinflammatory syndromes
Increased production of IL-1β causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as Cryopyrin-Associated Periodic Syndromes (CAPS), due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1B.
The mutated pyrin protein is thought to cause inappropriate activation of the inflammasome, leading to release of the pro-inflammatory cytokine IL-1β.

Inflammation

inflammatoryinflammatory responseinflamed
This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Inflammatory mediators that contribute to neoplasia include prostaglandins, inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-15 and chemokines such as IL-8 and GRO-alpha.

Canakinumab

Ilaris
Canakinumab is a human monoclonal antibody targeted at IL-1B, and approved in many countries for treatment of cryopyrin-associated periodic syndromes.
Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta.

Interleukin-1 family

IL-1interleukin-1interleukin 1
There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene).
In 1985 two distinct, but distantly related complementary DNAs encoding proteins sharing human IL-1 activity were reported to be isolated from a macrophage cDNA library, thus defining two individual members of the IL-1 family – IL-1α and IL-1β.

Cytokine

cytokineschemical signalscytokine-
Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

Protein

proteinsproteinaceousstructural proteins
Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

Gene

genesnumber of genesgene sequence
Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

Fever

pyrexiafebrileague
The fever-producing property of human leukocytic pyrogen (interleukin 1) was purified by Dinarello in 1977 (PNAS) with a specific activity of 10–20 nanograms/kg.

Apoptosis

apoptoticprogrammed cell deathcell death
This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Prostaglandin-endoperoxide synthase 2

COX-2cyclooxygenase 2cyclooxygenase-2
The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.

Central nervous system

CNScentralcentral nervous system (CNS)
The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.

Pain

physical painacute painnociceptive pain
The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.

Chromosome 2

2human chromosome 2Chromosome 2 (human)
This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Dalton (unit)

kDaDaDalton
The molecular weight of the proteolytically processed IL-1β is 17.5 kDa.

Dysbiosis

abnormal composition of the gut flora
Intestinal dysbiosis has been observed to induce osteomyelitis through a IL-1β dependent manner.

Osteomyelitis

bone infectionboneosteomylitis
Intestinal dysbiosis has been observed to induce osteomyelitis through a IL-1β dependent manner.

Homoglyph

looks exactly likehomoglyphiclooks the same as
Because many authors of scientific manuscripts make the minor error of using a homoglyph, [[ß|sharp s]], instead of beta, mentions of "IL-1ß" [sic] often become "IL-1ss" [sic] upon automated transcoding (because ß transcodes to ss).

Beta

ββGreek letter Beta
Because many authors of scientific manuscripts make the minor error of using a homoglyph, [[ß|sharp s]], instead of beta, mentions of "IL-1ß" [sic] often become "IL-1ss" [sic] upon automated transcoding (because ß transcodes to ss).

Transcoding

transcodetranscodertranscodes
Because many authors of scientific manuscripts make the minor error of using a homoglyph, [[ß|sharp s]], instead of beta, mentions of "IL-1ß" [sic] often become "IL-1ss" [sic] upon automated transcoding (because ß transcodes to ss).

Murine respirovirus

Sendai virusHemagglutinating virus of JapanSendai
V protein of SeV also suppresses the production of interleukin-1β, by inhibiting the assembly of the inflammasome NLRP3.

Sulfonylurea

sulfonylureassulphonylureasulphonylureas
Sulfonylureas are also used experimentally to inhibit interleukin 1 beta release from the NALP3 (or NLRP3) inflammasome.

Interleukin

interleukinsinterleukin 1βinterleukin-1β
Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.