Interrupted aortic arch

Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the aorta is not completely developed.wikipedia
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Coarctation of the aorta

aortic coarctationcoarctation of aortacoarctation
In a sense it is the complete form of a coarctation of the aorta.
Physiologically its complete form is manifested as interrupted aortic arch.

DiGeorge syndrome

22q11.2 deletion syndromevelocardiofacial syndrome22q11 deletion syndrome
Interrupted aortic arch (especially Type B) is often associated with DiGeorge syndrome.
Cardiac abnormality (commonly interrupted aortic arch, truncus arteriosus and tetralogy of Fallot)

Aorta

aorticaortic archaortic root
Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the aorta is not completely developed.

Apoptosis

apoptoticprogrammed cell deathcell death
It is thought that an interrupted aortic arch occurs through excessive apoptosis in the developing, embryonic aorta.

Echocardiography

echocardiogramechocardiographicultrasound of the heart
It can be diagnosed with a standard echocardiogram.

Ultrasound

ultrasonicultrasonicsultrasounds
The diagnosis can also be made prior to birth via ultrasound.

Tachypnea

rapid breathingtachypnoeaincreased rate of breathing
Patients will have a loss of appetite, appear tired and weak, and exhibit rapid breathing and a rapid heart rate.

Tachycardia

fast heart rateincreased heart raterapid heart rate
Patients will have a loss of appetite, appear tired and weak, and exhibit rapid breathing and a rapid heart rate.

Brachial artery

brachialbrachial arteriesbrachioradial artery
The pattern of pulse abnormalities is dependent upon the classification; e.g., for type B interrupted aortic arch, the right brachial pulse will be palpable and the left brachial and femoral pulses will be impalpable due to closure of the ductus arteriosus.

Palpation

palpablepalpatedpalpate
The pattern of pulse abnormalities is dependent upon the classification; e.g., for type B interrupted aortic arch, the right brachial pulse will be palpable and the left brachial and femoral pulses will be impalpable due to closure of the ductus arteriosus.

Femoral artery

femoralsuperficial femoral arteryfemoral arteries
The pattern of pulse abnormalities is dependent upon the classification; e.g., for type B interrupted aortic arch, the right brachial pulse will be palpable and the left brachial and femoral pulses will be impalpable due to closure of the ductus arteriosus.

Ductus arteriosus

ductus arteriosisductal
The pattern of pulse abnormalities is dependent upon the classification; e.g., for type B interrupted aortic arch, the right brachial pulse will be palpable and the left brachial and femoral pulses will be impalpable due to closure of the ductus arteriosus.

Intracranial aneurysm

brain aneurysmcerebral aneurysmaneurysm
Rarely, an interrupted aortic arch can be associated with an intracranial aneurysm.

Ischemia

ischemicischaemiaischaemic
Signs of ischemia due to interrupted aortic arch can be separated by the organ system involved:

CHARGE syndrome

Australasian Charge Syndrome AssociationCHARGECHARGE Association
CHARGE syndrome, a specific, rare pattern of genetic abnormalities, commonly features conotruncal and aortic arch heart defects, which can include an interrupted aortic arch.

Bulbus cordis

conotruncal
CHARGE syndrome, a specific, rare pattern of genetic abnormalities, commonly features conotruncal and aortic arch heart defects, which can include an interrupted aortic arch.

Aortic arch

arch of the aortaaortic knobisthmus of aorta
CHARGE syndrome, a specific, rare pattern of genetic abnormalities, commonly features conotruncal and aortic arch heart defects, which can include an interrupted aortic arch.

Hepatotoxicity

liver damagehepatotoxicliver toxicity
Liver injury: elevated serum glutamic oxaloacetic transaminase (SGOT) (also known as aspartate transaminase, AST) and lactic acid dehydrogenase (LDH)

Aspartate transaminase

ASTaspartate aminotransferaseserum glutamic oxaloacetic transaminase
Liver injury: elevated serum glutamic oxaloacetic transaminase (SGOT) (also known as aspartate transaminase, AST) and lactic acid dehydrogenase (LDH)

Lactate dehydrogenase

LDHlactic acid dehydrogenaselactic dehydrogenase
Liver injury: elevated serum glutamic oxaloacetic transaminase (SGOT) (also known as aspartate transaminase, AST) and lactic acid dehydrogenase (LDH)

Nephrotoxicity

nephrotoxicnephrotoxinKidney damage
Kidney injury: elevated serum creatinine

Creatinine

serum creatininenormal renal functioncreatinin
Kidney injury: elevated serum creatinine

Gastrointestinal tract

intestinegastrointestinaldigestive tract
Intestinal injury: signs of necrotizing enterocolitis, such as bloody stools

Necrotizing enterocolitis

necrotising enterocolitisenterocolitis, necrotizingNEC
Intestinal injury: signs of necrotizing enterocolitis, such as bloody stools

Blood in stool

blood in the stoolbloody stoolbloody stools
Intestinal injury: signs of necrotizing enterocolitis, such as bloody stools