Intracrine

intracrine signalingintracrine signalling
Intracrine refers to a hormone that acts inside a cell, regulating intracellular events.wikipedia
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Hormone

hormoneshormonalprohormone
Intracrine refers to a hormone that acts inside a cell, regulating intracellular events.
The term "hormone" is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signalling).

Endocrine system

endocrineendocrinologicalendocrine organ
In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface.
The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signalling) or nearby cells (paracrine signalling).

Renin–angiotensin system

renin–angiotensin–aldosterone systemrenin-angiotensin-aldosterone systemrenin angiotensin system

Angiotensin

angiotensin IIangiotensin Iangiotensinogen
Angiotensin II also increases aldosterone secretion, therefore, it acts as an endocrine, autocrine/paracrine, and intracrine hormone.

Autocrine signaling

autocrineautocrine signallingautocrine loop
In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface.
This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling.

Parathyroid hormone-related protein

PTHLHPTHrPparathyroid hormone-related peptide
PTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone.

Cell (biology)

cellcellscellular
Intracrine refers to a hormone that acts inside a cell, regulating intracellular events.

Receptor (biochemistry)

receptorreceptorscellular receptors
Steroid hormones act through intracellular (mostly nuclear) receptors and, thus, may be considered to be intracrines.

Peptide

polypeptidepeptidespolypeptides
In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface.

Protein

proteinsproteinaceousstructural proteins
In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface.

Paracrine signaling

paracrineparacrine signallinglocal hormones
In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface.

Gastrointestinal tract

intestinegastrointestinaldigestive tract
These digestive hormones, including gastrin, secretin, cholecystokinin, and ghrelin, are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are conserved structures throughout evolution.

Dihydrotestosterone

5α-DihydrotestosteroneDHT17-hydroxyandrostan-3-one
DHT signals mainly in an intracrine and paracrine manner in the tissues in which it is produced, playing only a minor role, if any, as a circulating endocrine hormone.

Endocrinology

endocrinologistendocrinologistsendocrinopathy
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical that acts within the same cell).

Cell signaling

cell signallingsignallingsignaling pathway
Signaling molecules interact with a target cell as a ligand to cell surface receptors, and/or by entering into the cell through its membrane or endocytosis for intracrine signaling.

Fibroblast growth factor

FGFfibroblast growth factorsFGFs
LMW FGF2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF2s are nuclear and exert activities through an intracrine mechanism.

Peptide hormone

peptide hormonesprotein hormonepolypeptide hormone
Some peptide/protein hormones (angiotensin II, basic fibroblast growth factor-2, parathyroid hormone-related protein) also interact with intracellular receptors located in the cytoplasm or nucleus by an intracrine mechanism.

Intracellular receptor

intracellularcytoplasmic and nuclear receptornuclear receptor
Some intracrine peptide hormones also have intracellular receptors.

Leukotriene C4

LTC4LTC 4 C4
Acting in an intracrine manner, LTC 4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ROS accumulation and oxidative DNA damage.