Janus kinase 3

JAK3
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.wikipedia
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Tyrosine kinase 2

TYK2TYK
Other members of the Janus family include JAK1, JAK2 and TYK2.
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).

Janus kinase

JAKJAK kinasesJanus Kinases
Janus kinase 3 is a tyrosine kinase that belongs to the janus family of kinases.

Interleukin 2

IL-2interleukin-2IL2
IL-2 plays a role in intestinal epithelial cell (IEC) homeostasis through concentration-dependent regulation of IEC proliferation and cell death. JAK3 is activated only by cytokines whose receptors contain the common gamma chain (γc) subunit: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.
This leads to the activation of Janus kinases JAK1 and JAK3 which subsequently phosphorylate T338 on CD122.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.
ITK; JAK1; JAK2; JAK3;

Janus kinase 3 inhibitor

inhibition of JAK3inhibitor of Janus kinase 3JAK3 inhibitor
Moreover, unlike other JAKs, JAK3 is primarily expressed in hematopoietic cells, so a highly specific JAK3 inhibitor should have precise effects on immune cells and minimal pleiotropic defects.
Janus Kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus Kinase 3.

Interleukin 15

IL-15interleukin-15IL15
JAK3 is activated only by cytokines whose receptors contain the common gamma chain (γc) subunit: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.
Upon binding IL-15β subunit activates Janus kinase 1 (Jak1) and γc subunit Janus kinase 3 (Jak3), which leads to phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5.

Severe combined immunodeficiency

SCIDSevere Combined Immune DeficiencySevere combined immunodeficiency (SCID)
Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease), while activating Janus kinase 3 mutations lead to the development of leukemia.

Tofacitinib

tasocitinibTofacitinib citrateXeljanz
CP-690550 (Tofacitinib) is currently being market by Pfizer as Xeljanz for the treatment of rheumatoid arthritis.
It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3), which means that it interferes with the JAK-STAT signaling pathway, which transmits extracellular information into the cell nucleus, influencing DNA transcription.

CD247

ζ-chainCD3ζCD3-zeta
Janus kinase 3 has been shown to interact with CD247, TIAF1 and IL2RG.
CD247 has been shown to interact with Janus kinase 3 and Protein unc-119 homolog.

TIAF1

Janus kinase 3 has been shown to interact with CD247, TIAF1 and IL2RG.
TIAF1 has been shown to interact with Janus kinase 3 and TRIB3.

Common gamma chain

IL2RGCD132gamma
JAK3 is activated only by cytokines whose receptors contain the common gamma chain (γc) subunit: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Janus kinase 3 has been shown to interact with CD247, TIAF1 and IL2RG. JAK3 is required for signaling of the type I receptors that use the common gamma chain (γc).
IL2RG has been shown to interact with Janus kinase 3.

Enzyme

enzymologyenzymesenzymatic
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.

Gene

genesnumber of genesgene sequence
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.

Janus kinase 1

JAK1JAKJAK 1
Other members of the Janus family include JAK1, JAK2 and TYK2.

Janus kinase 2

JAK22JAK
Other members of the Janus family include JAK1, JAK2 and TYK2.

Granulocyte-macrophage colony-stimulating factor

GM-CSFgranulocyte macrophage colony-stimulating factorgranulocyte-macrophage colony stimulating factor