A report on Korsakoff syndrome

Thiamine

Disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.

- Korsakoff syndrome
Thiamine

13 related topics with Alpha

Overall

Thiamine

Wernicke–Korsakoff syndrome

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Thiamine
Axial MRI FLAIR image showing hyperintense signal in the mesial dorsal thalami, a common finding in Wernicke encephalopathy. This patient was nearly in coma when IV thiamine was started, he responded moderately well but was left with some Korsakoff type deficits.
Axial MRI B=1000 DWI image showing hyperintense signal indicative of restricted diffusion in the mesial dorsal thalami.
Axial MRI FLAIR image showing hyperintense signal in the periaqueductal gray matter and tectum of the dorsal midbrain.

Wernicke–Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and Korsakoff syndrome.

Amnesie

Amnesia

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Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Amnesie

This type of dissociation between declarative and procedural memory can also be found in patients with diencephalic amnesia such as Korsakoff's syndrome.

A beriberi patient during the early twentieth century in Southeast Asia, displaying characteristic difficulty with walking

Thiamine deficiency

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Medical condition of low levels of thiamine .

Medical condition of low levels of thiamine .

A beriberi patient during the early twentieth century in Southeast Asia, displaying characteristic difficulty with walking
Oxidation of thiamine derivatives to fluorescent thiochromes by potassium ferricyanide under alkaline conditions

Wernicke encephalopathy and Korsakoff syndrome are forms of dry beriberi.

Hypothalamus

Wernicke encephalopathy

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Presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

Presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

Hypothalamus
Cerebellum

The condition is part of a larger group of thiamine deficiency disorders that includes beriberi, in all its forms, and alcoholic Korsakoff syndrome.

Korsakov in 1885

Sergei Korsakoff

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Russian neuropsychiatrist, known for his studies on alcoholic psychosis.

Russian neuropsychiatrist, known for his studies on alcoholic psychosis.

Korsakov in 1885
Ob alkogol’nom paraliche (Alcoholic Paralysis) - 1887
Ob alkogol’nom paraliche (Alcoholic Paralysis) - 1887 - author's dedication

His name is lent to the eponymous Korsakoff's syndrome and Wernicke–Korsakoff syndrome.

Alcohol (drug)

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Psychoactive drug that is the active ingredient in drinks such as beer, wine, and distilled spirits .

Psychoactive drug that is the active ingredient in drinks such as beer, wine, and distilled spirits .

Symptoms of varying BAC levels. Additional symptoms may occur.
A 2010 study ranking various illegal and legal drugs based on statements by drug-harm experts. Alcohol was found to be the overall most dangerous drug, and the only drug that mostly damaged others.
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational substances. Alcohol was ranked 6th in dependence, 11th in physical harm, and 2nd in social harm.
Diagram of mucosal layer

Alcohol can cause brain damage, Wernicke's encephalopathy and Alcoholic Korsakoff syndrome (AKS) which frequently occur simultaneously, known as Wernicke–Korsakoff syndrome (WKS).

Confabulation

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Memory error defined as the production of fabricated, distorted, or misinterpreted memories about oneself or the world.

Memory error defined as the production of fabricated, distorted, or misinterpreted memories about oneself or the world.

This type of confabulation is commonly seen in Korsakoff's syndrome.

Retrograde amnesia

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Loss of memory-access to events that occurred or information that was learned in the past.

Loss of memory-access to events that occurred or information that was learned in the past.

RA can also progress and further deteriorate memory recollection, as in the case of Korsakoff syndrome and Alzheimer's disease, due to the ongoing nature of the damage caused by the illnesses.

Hippocampus (brain)

Anterograde amnesia

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Loss of the ability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

Loss of the ability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

Hippocampus (brain)

Chronic alcoholism often leads to a thiamine (vitamin B1) deficiency in the brain, causing Korsakoff's syndrome, a neurological disorder which is generally preceded by an acute neurological condition known as Wernicke's encephalopathy (WE).

Micrograph showing gliosis in the cerebellum. Reactive astrocytes on the left display severe proliferation and domain overlap.

Gliosis

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Nonspecific reactive change of glial cells in response to damage to the central nervous system .

Nonspecific reactive change of glial cells in response to damage to the central nervous system .

Micrograph showing gliosis in the cerebellum. Reactive astrocytes on the left display severe proliferation and domain overlap.

Additionally, gliosis is present in a wide variety of CNS pathologies, including Alzheimer's disease, Korsakoff's syndrome, multiple system atrophy, prion disease, multiple sclerosis, AIDS dementia complex, vasculitis, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease.