A report on Leo Sternbach

Villa Adriatic where Leo Sternbach spent his childhood in Opatija, Croatia

Polish American chemist who is credited with first synthesizing benzodiazepines, the main class of tranquilizers.

- Leo Sternbach

9 related topics with Alpha

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Structural formula of benzodiazepines.

Benzodiazepine

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Fusion of a benzene ring and a diazepine ring.

Fusion of a benzene ring and a diazepine ring.

Structural formula of benzodiazepines.
Midazolam 1 & 5 mg/mL injections (Canada)
Temazepam (Normison) 10 mg tablets
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Benzodiazepines were ranked in this graph 7th in dependence, physical harm, and social harm.
Diazepam 2 mg and 5 mg diazepam tablets, which are commonly used in the treatment of benzodiazepine withdrawal.
Chlordiazepoxide 5 mg capsules, which are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam it has a long elimination half-life and long-acting active metabolites.
Schematic diagram of the (α1)2(β2)2(γ2) GABAA receptor complex that depicts the five-protein subunits that form the receptor, the chloride (Cl−) ion channel pore at the center, the two GABA active binding sites at the α1 and β2 interfaces and the benzodiazepine (BZD) allosteric binding site at the α1 and γ2 interface.
Left: The 1,4-benzodiazepine ring system. Right: 5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one forms the skeleton of many of the most common benzodiazepine pharmaceuticals, such as diazepam (7-chloro-1-methyl substituted).
A pharmacophore model of the benzodiazepine binding site on the GABAA receptor. White sticks represent the carbon atoms of the benzodiazepine diazepam, while green represents carbon atoms of the nonbenzodiazepine CGS-9896. Red and blue sticks are oxygen and nitrogen atoms that are present in both structures. The red spheres labeled H1 and H2/A3 are, respectively, hydrogen bond donating and accepting sites in the receptor, while L1, L2, and L3 denote lipophilic binding sites.
The molecular structure of chlordiazepoxide, the first benzodiazepine. It was marketed by Hoffmann–La Roche from 1960 branded as Librium.
Xanax (alprazolam) 2 mg tri-score tablets

The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963.

Rohypnol 1 mg tablets.

Flunitrazepam

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Benzodiazepine used to treat severe insomnia and assist with anesthesia.

Benzodiazepine used to treat severe insomnia and assist with anesthesia.

Rohypnol 1 mg tablets.
Hypnodorm 1 mg flunitrazepam tablets, Australia
Rohypnol
Icelandic Flunitrazepam

Flunitrazepam was discovered at Roche as part of the benzodiazepine work led by Leo Sternbach; the patent application was filed in 1960 and it was first marketed in 1972.

Jagiellonian University

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Public research university in Kraków, Poland.

Public research university in Kraków, Poland.

The founding of the University in 1364, painted by Jan Matejko (1838–1893)
The main assembly hall of the university's Collegium Maius
The main baroque entrance to the university's Collegium Iuridicum
The Collegium Novum in the Old Town District
Count Stanisław Tarnowski was, between 1871 and 1909, twice rector of the university.
The university around 1930
The Jagiellonian Library's main site
The Jagiellonian Library extension
Monument to Nicolaus Copernicus next to Jagiellonian University's Collegium Novum
Ignacy Łukasiewicz
Bronisław Malinowski
Krzysztof Penderecki
Wisława Szymborska
Pope John Paul II
Heraldic frieze on the building of Collegium Maius depicting coats of arms of the Kraków bishops, chancellors, cardinals as well as Elizabeth of Austria, Crown of the Kingdom of Poland, Grand Duchy of Lithuania and the Kraków Academy

In addition to Copernicus, the university's notable alumni include heads of state King John III Sobieski, Pope John Paul II, and Andrzej Duda; Polish prime ministers Beata Szydło and Józef Cyrankiewicz; renowned cultural figures Jan Kochanowski, Stanisław Lem, and Krzysztof Penderecki; and leading intellectuals and researchers such as Hugo Kołłątaj, Bronisław Malinowski, Carl Menger, Leo Sternbach, and Norman Davies.

Diazepam tablets (10, 5, and 2 mg)

Diazepam

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Medicine of the benzodiazepine family that acts as an anxiolytic.

Medicine of the benzodiazepine family that acts as an anxiolytic.

Diazepam tablets (10, 5, and 2 mg)
5 mg Valium Roche packaging Australia

Diazepam was the second benzodiazepine invented by Leo Sternbach of Hoffmann-La Roche at the company's Nutley, New Jersey, facility following chlordiazepoxide (Librium), which was approved for use in 1960.

Moses Wolf Goldberg

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Dr Moses Wolf Goldberg (June 30, 1905 – February 17, 1964) was an Estonian-Jewish chemist who, along with Leo Henryk Sternbach, developed a process for the synthesis of biotin (a B vitamin) in 1949.

Opatija

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Town and a municipality in Primorje-Gorski Kotar County in western Croatia.

Town and a municipality in Primorje-Gorski Kotar County in western Croatia.

Seaside of Opatija in September 2006.
Villa Angiolina in October 2007.
1911 poster
Maiden with the Seagull
St. Jacob's Church
Villa Angiolina
Hotel Kvarner
Hotel Opatija
Fiat Mokarabia at the Chocolate Festival
Miroslav Krleža statue
Opatija at night
"Ambasador" Hotel
Beaches
Bronze bust of Anton Chekhov

Leo Sternbach (1908–2005), born in Opatija

Gustav Sorge

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SS senior NCO (Hauptscharführer).

SS senior NCO (Hauptscharführer).

Among the many people who were murdered at Sachsenhausen by Sorge was Leon Sternbach, a professor of classical philology at the Jagiellonian University and the paternal uncle of famed chemist, Leo Sternbach.

Upper Montclair, New Jersey

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Census-designated place , unincorporated community and neighborhood within Montclair in Essex County, New Jersey, United States.

Census-designated place , unincorporated community and neighborhood within Montclair in Essex County, New Jersey, United States.

Mt. Hebron Middle School
Mountain Avenue station
#66, stopping in Upper Montclair
Aldrin walks on the surface of the Moon during Apollo 11.
Yael Averbuch
Business district in Upper Montclair, which is around the intersection of Valley Road and Bellevue Avenue
Upper Montclair's library, which is called the Bellevue Branch
A landmark in Upper Montclair, a clock owned by Chase bank that is situated in the center of town and was installed around 1910. About 2004, the clock was sent away for needed refurbishment.
Anderson Park
Presby Memorial Iris Gardens
A movie being filmed in Upper Montclair
the Montclair Women's Club
Brookdale Park

Dr. Leo Sternbach (1908–2005), chemist, invented precursor to Valium.

Chapel Hill, North Carolina

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Town in Orange, Durham and Chatham counties in the U.S. state of North Carolina.

Town in Orange, Durham and Chatham counties in the U.S. state of North Carolina.

A mural at Amber Alley between Franklin and Rosemary streets
Chapel Hill fire truck, painted with the colors of the University of North Carolina at Chapel Hill
The Sorrell building on Franklin Street has housed a movie theater (currently called the Varsity Theatre) since its construction in 1927.
UNC's wooded campus buffers the town center

Leo Sternbach, chemist and discoverer of benzodiazepines