Lisdexamfetamine

Vyvanselisdexamfetamine dimesylatelisdexamphetamineparticularVyvanse (Elvanse in the European market)
Lisdexamfetamine, sold under the brand name Vyvanse among others, is a medication that is used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as for moderate to severe binge eating disorder in adults.wikipedia
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Stimulant

stimulantspsychostimulantpsychostimulants
Lisdexamfetamine is a central nervous system (CNS) stimulant that works after being converted by the body into dextroamphetamine.
The most frequently prescribed stimulants as of 2013 were lisdexamfetamine, methylphenidate, and amphetamine.

Binge eating disorder

Binge Eatingbinge-eating disorderBinge Eating Disorder (BED)
Lisdexamfetamine, sold under the brand name Vyvanse among others, is a medication that is used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as for moderate to severe binge eating disorder in adults.
Counselling and certain medication, such as lisdexamfetamine and selective serotonin reuptake inhibitor (SSRIs), may help.

Dextroamphetamine

Dexedrined-amphetamineDexamphetamine
Lisdexamfetamine is a central nervous system (CNS) stimulant that works after being converted by the body into dextroamphetamine. The optical isomers of amphetamine, i.e., dextroamphetamine and levoamphetamine, are TAAR1 agonists and vesicular monoamine transporter 2 inhibitors that can enter monoamine neurons; this allows them to release monoamine neurotransmitters (dopamine, norepinephrine, and serotonin, among others) from their storage sites in the presynaptic neuron, as well as prevent the reuptake of these neurotransmitters from the synaptic cleft. Lisdexamfetamine is a substituted amphetamine with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L -lysine.
Dextroamphetamine is sometimes prescribed as the inactive prodrug lisdexamfetamine dimesylate, which is converted into dextroamphetamine after absorption.

Serotonin syndrome

hyperserotonemiaserotonin toxicitycentral toxic serotonin reaction
Serotonin syndrome may occur if used with certain other medications.

Codrug

composed of
Chemically, lisdexamfetamine is composed of the amino acid L -lysine, attached to dextroamphetamine.

Controlled Substances Act

Schedule ISchedule IISchedule III
It is a Schedule II controlled substance in the United Kingdom and a Schedule II controlled substance in the United States.

Amphetamine

Benzedrinespeedamphetamines
The optical isomers of amphetamine, i.e., dextroamphetamine and levoamphetamine, are TAAR1 agonists and vesicular monoamine transporter 2 inhibitors that can enter monoamine neurons; this allows them to release monoamine neurotransmitters (dopamine, norepinephrine, and serotonin, among others) from their storage sites in the presynaptic neuron, as well as prevent the reuptake of these neurotransmitters from the synaptic cleft.
Currently, pharmaceutical amphetamine is prescribed as racemic amphetamine, Adderall, dextroamphetamine, or the inactive prodrug lisdexamfetamine.

Psychosis

psychoticpsychosespsychotic break
The USFDA advises anyone with bipolar disorder, depression, elevated blood pressure, liver or kidney problems, mania, psychosis, Raynaud's phenomenon, seizures, thyroid problems, tics, or Tourette syndrome to monitor their symptoms while taking amphetamine.
Stimulants that may cause this include lisdexamfetamine.

Shire (pharmaceutical company)

ShireShire plcShire Pharmaceuticals
Lisdexamfetamine was developed by New River Pharmaceuticals, who were bought by Takeda Pharmaceuticals through its acquisition of Shire Pharmaceuticals, shortly before it began being marketed.
Originating in the United Kingdom with an operational base in the United States, its brands and products included Vyvanse, Lialda, and Adderall XR.

Monoamine oxidase inhibitor

MAOImonoamine oxidase inhibitorsMAOIs
It is also contraindicated in patients who have used a monoamine oxidase inhibitor (MAOI) within the last 14 days.

Substituted amphetamine

amphetaminesamphetaminesubstituted amphetamines
Lisdexamfetamine is a substituted amphetamine with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L -lysine.
A variety of prodrugs of amphetamine and/or methamphetamine exist, and include amfecloral, amphetaminil, benzphetamine, clobenzorex, D -deprenyl, dimethylamphetamine, ethylamphetamine, fencamine, fenethylline, fenproporex, furfenorex, lisdexamfetamine, mefenorex, mesocarb, prenylamine, and selegiline.

Adderall

Adderall XRamphetamine mixed saltsmixed amphetamine salts
As opposed to Adderall, which contains roughly equal parts of racemic amphetamine and dextroamphetamine salts, lisdexamfetamine is a single-enantiomer dextroamphetamine formula.

Prodrug

pro-drugprodrugsinactive prodrug
Lisdexamfetamine is an inactive prodrug that is converted in the body to dextroamphetamine, a pharmacologically active compound which is responsible for the drug's activity.

Attention deficit hyperactivity disorder

ADHDattention deficit disorderhyperactivity
Lisdexamfetamine, sold under the brand name Vyvanse among others, is a medication that is used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as for moderate to severe binge eating disorder in adults.

Methylphenidate

RitalinConcertaMethylin
In the United Kingdom it is usually less preferred than methylphenidate.

Insomnia

trouble sleepingsleeplessnessdifficulty sleeping
Common side effects of lisdexamfetamine include loss of appetite, anxiety, diarrhea, trouble sleeping, irritability, and nausea.

Mania

manicmanic episodemanic episodes
The USFDA advises anyone with bipolar disorder, depression, elevated blood pressure, liver or kidney problems, mania, psychosis, Raynaud's phenomenon, seizures, thyroid problems, tics, or Tourette syndrome to monitor their symptoms while taking amphetamine. Rare but serious side effects include mania, sudden cardiac death in those with underlying heart problems, and psychosis.

Cardiac arrest

sudden cardiac deathsudden deathcardiopulmonary arrest
Rare but serious side effects include mania, sudden cardiac death in those with underlying heart problems, and psychosis.

Stimulant psychosis

amphetamine psychosispsychosisdrug-induced psychosis
Rare but serious side effects include mania, sudden cardiac death in those with underlying heart problems, and psychosis.

Abuse

abusiveabuse of officemaltreatment
It has a high potential for abuse per the DEA.

Drug Enforcement Administration

DEAUnited States Drug Enforcement AdministrationU.S. Drug Enforcement Administration
It has a high potential for abuse per the DEA.

Pregnancy

pregnantfirst trimesterpregnant women
Its use during pregnancy may result in harm to the baby and use during breastfeeding is not recommended by the manufacturer.

Breastfeeding

breast feedingbreastfeedbreast-feeding
Its use during pregnancy may result in harm to the baby and use during breastfeeding is not recommended by the manufacturer.

Central nervous system

CNScentralcentral nervous system (CNS)
Lisdexamfetamine is a central nervous system (CNS) stimulant that works after being converted by the body into dextroamphetamine.

Amino acid

amino acidsresiduesresidue
Chemically, lisdexamfetamine is composed of the amino acid L -lysine, attached to dextroamphetamine.