Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)
Sorrowing Old Man (At Eternity's Gate)
by Vincent van Gogh (1890)
Schematic overview of the classes of stresses that plants are exposed to
Locus coeruleus and its influence pathways
An 1892 lithograph of a woman diagnosed with melancholia
Neuro-hormonal response to stress
A cup analogy demonstrating the diathesis–stress model that under the same amount of stressors, person 2 is more vulnerable than person 1, because of their predisposition.
A diagram of the General Adaptation Syndrome model.
Caricature of a man with depression
Physical exercise is one recommended way to manage mild depression.
Sertraline (Zoloft) is used primarily to treat major depression in adults.
Diagnoses of depression go back at least as far as Hippocrates.
The 16th American president, Abraham Lincoln, had "melancholy", a condition that now may be referred to as clinical depression.

The locus coeruleus (LC), also spelled locus caeruleus or locus ceruleus, is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic.

- Locus coeruleus

Chronic stress, and a lack of coping resources available, or used by an individual, can often lead to the development of psychological issues such as delusions, depression and anxiety (see below for further information).

- Stress (biology)

The locus coeruleus may figure in clinical depression, panic disorder, Parkinson's disease, Alzheimer's disease and anxiety.

- Locus coeruleus

Third, decreased size of the locus coeruleus, decreased activity of tyrosine hydroxylase, increased density of alpha-2 adrenergic receptor, and evidence from rat models suggest decreased adrenergic neurotransmission in depression.

- Major depressive disorder

Excluded are a range of related diagnoses, including dysthymia, which involves a chronic but milder mood disturbance; recurrent brief depression, consisting of briefer depressive episodes; minor depressive disorder, whereby only some symptoms of major depression are present; and adjustment disorder with depressed mood, which denotes low mood resulting from a psychological response to an identifiable event or stressor.

- Major depressive disorder

Antishock phase: When the threat or stressor is identified or realized, the body starts to respond and is in a state of alarm. During this stage, the locus coeruleus and sympathetic nervous system activate the production of catecholamines including adrenaline, engaging the popularly-known fight-or-flight response. Adrenaline temporarily provides increased muscular tonus, increased blood pressure due to peripheral vasoconstriction and tachycardia, and increased glucose in blood. There is also some activation of the HPA axis, producing glucocorticoids (cortisol, aka the S-hormone or stress-hormone).

- Stress (biology)
Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)

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