Lysophosphatidic acid phosphatase type 6

ACP6
Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene.wikipedia
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Acid phosphatase

acid phosphatasesacidic phosphatase
Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene. It acts as a phosphomonoesterase at low pHs.

1q21.1 deletion syndrome

1q211q21.1
Genes related to 1q21.1 deletion in the distal area are PDE4DIP, HYDIN2, PRKAB2, PDIA3P, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, NBPF10, GPR89B, GPR89C, PDZK1P1 and NBPF11.

1q21.1 duplication syndrome

Genes related to 1q21.1 deletion in the distal area are HYDIN2, PRKAB2, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, and GPR89B.

Enzyme

enzymologyenzymesenzymatic
Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene.

Gene

genesnumber of genesgene sequence
Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene.

PH

pH levelneutralpH value
It acts as a phosphomonoesterase at low pHs.

Hydrolysis

hydrolyzedhydrolysehydrolyze
It is responsible for the hydrolysis of Lysophosphatidic acids (LPAs) to their respective monoacylglycerols and the release a free phosphate group in the process.

Lysophosphatidic acid

LPALPA specieslysophosphatidic acid (LPA)
It is responsible for the hydrolysis of Lysophosphatidic acids (LPAs) to their respective monoacylglycerols and the release a free phosphate group in the process.

Monoglyceride

monoacylglycerolmonoglyceridesmono-
It is responsible for the hydrolysis of Lysophosphatidic acids (LPAs) to their respective monoacylglycerols and the release a free phosphate group in the process.

Myristic acid

myristicmyristoylmyristate
The enzyme has higher activity for myristate-LPA (14 carbon chain), oleate-LPA (18 carbon chain and one unsaturated carbon-carbon bond), laurate-LPA (12 carbon chain) or palmitate-LPA (16 carbon chain).

Oleic acid

oleicoleateoleoyl
The enzyme has higher activity for myristate-LPA (14 carbon chain), oleate-LPA (18 carbon chain and one unsaturated carbon-carbon bond), laurate-LPA (12 carbon chain) or palmitate-LPA (16 carbon chain).

Lauric acid

lauriclauratedodecanoic acid
The enzyme has higher activity for myristate-LPA (14 carbon chain), oleate-LPA (18 carbon chain and one unsaturated carbon-carbon bond), laurate-LPA (12 carbon chain) or palmitate-LPA (16 carbon chain).

Palmitic acid

palmitatepalmitichexadecanoic acid
The enzyme has higher activity for myristate-LPA (14 carbon chain), oleate-LPA (18 carbon chain and one unsaturated carbon-carbon bond), laurate-LPA (12 carbon chain) or palmitate-LPA (16 carbon chain).

Stearate

salt
When the substrate is stearate-LPA (18 carbon chain), the enzyme has reduced activity.

Angiogenesis

angiogenicvascularizationvascularized
LPAs are necessary for healthy cell growth, survival and pro-angiogenic factors for both in vivo and in vitro cells.

In vivo

in-vivoliving tissueanimal
LPAs are necessary for healthy cell growth, survival and pro-angiogenic factors for both in vivo and in vitro cells.

In vitro

in-vitrolaboratoryartificially
LPAs are necessary for healthy cell growth, survival and pro-angiogenic factors for both in vivo and in vitro cells.

Metabolic disorder

metabolic disordersmetabolic diseasemetabolic diseases
Unbalanced concentrations of lysophosphatidic acid phosphatase can frequently lead to unbalanced LPA concentrations, which can cause metabolic disorders, and lead to ovarian cancer in women.

Ovarian cancer

ovarianovarian carcinomaovary
Unbalanced concentrations of lysophosphatidic acid phosphatase can frequently lead to unbalanced LPA concentrations, which can cause metabolic disorders, and lead to ovarian cancer in women.

Monomer

monomersmonomeric-mer
Lysophosphatidic acid phosphatase is a monomer composed of two domains.

Protein domain

domainsdomainstructural domain
Lysophosphatidic acid phosphatase is a monomer composed of two domains.

Alpha helix

alpha helicesα-helicesalpha-helices
The enzyme has two alpha helices on one side, seven beta sheets in the middle, and two more α helices on the opposite side.

Beta sheet

β-sheetbeta sheetsbeta strand
The enzyme has two alpha helices on one side, seven beta sheets in the middle, and two more α helices on the opposite side.

Hydrophile

hydrophilichydrophilicityHydrophilia
This channel is lined with hydrophilic residues that lead the water molecule to the active site, where the terminal water molecule interacts with Asp-335 residue and is then activated.