MDMA

ecstasymethylenedioxymethamphetamineE3,4-methylenedioxy-''N''-methylamphetaminemolly3,4-methylenedioxymethamphetamineecstasy pillsecstasy tabletsXTCMDMA (ecstasy)
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (E), is a psychoactive drug primarily used as a recreational drug.wikipedia
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Recreational drug use

recreational drugdrug usedrugs
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (E), is a psychoactive drug primarily used as a recreational drug.
What controlled substances are considered illegal drugs varies by country, but usually includes methamphetamines, heroin, cocaine, LSD, psilocybin mushrooms, MDMA and club drugs.

Psychoactive drug

psychoactivepsychotropicdrug
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (E), is a psychoactive drug primarily used as a recreational drug.
Example: MDMA (Ecstasy), MDA, 6-APB, AMP

Stimulant

psychostimulantstimulantspsychostimulants
It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.
It is estimated that the percentage of the population that has abused amphetamine-type stimulants (e.g., amphetamine, methamphetamine, MDMA, etc.) and cocaine combined is between 0.8% and 2.1%.

Substituted amphetamine

amphetaminesamphetaminesubstituted amphetamines
It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.
Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, mephentermine, bupropion, methoxyphenamine, selegiline, amfepramone, pyrovalerone, MDMA (ecstasy), and DOM (STP).

Empathogen–entactogen

entactogenentactogenicempathogen
Entactogenic effects – increased empathy or feelings of closeness with others and oneself
Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA).

Amphetamine

speedbenzedrineamphetamines
It is often sold mixed with other substances such as ephedrine, amphetamine, and methamphetamine.
It is also the parent compound of its own structural class, the substituted amphetamines, which includes prominent substances such as bupropion, cathinone, MDMA, and methamphetamine.

Insomnia

sleeplessnesstrouble sleepingdifficulty sleeping
Adverse effects include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating, and a rapid heartbeat.
Use of psychoactive drugs (such as stimulants), including certain medications, herbs, caffeine, nicotine, cocaine, amphetamines, methylphenidate, aripiprazole, MDMA, modafinil, or excessive alcohol intake.

Mephedrone

4-Methylmethcathinone4-MMCMiaow-Miaow
In part due to the global supply shortage of sassafras oil, substances that are sold as molly frequently contain no MDMA and instead contain methylone, ethylone, MDPV, mephedrone, or any other of the group of compounds commonly known as bath salts.
It comes in the form of tablets or a powder, which users can swallow, snort or inject, producing similar effects to MDMA, amphetamines and cocaine.

Methylone

3,4-Methylenedioxy-''N''-methylcathinone
In part due to the global supply shortage of sassafras oil, substances that are sold as molly frequently contain no MDMA and instead contain methylone, ethylone, MDPV, mephedrone, or any other of the group of compounds commonly known as bath salts.
Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone.

Bruxism

sleep bruxismteeth grindinggrinding of teeth
Adverse effects include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating, and a rapid heartbeat.
Methylenedioxymethamphetamine (MDMA, ecstasy) has been reported to be associated with bruxism, which occurs immediately after taking the drug and for several days afterwards.

Adulterant

adulterationadulteratedfood adulteration
MDMA has become widely known as ecstasy (shortened "E", "X", or "XTC"), usually referring to its tablet form, although this term may also include the presence of possible adulterants or dilutants.
Cutting agents used to adulterate (or "cut") illicit drugs—for example, shoe polish in hashish, amphetamines in ecstasy, lactose in cocaine

Electronic dance music

EDMdanceelectronic dance
MDMA is commonly associated with dance parties, raves, and electronic dance music.
Both places became synonymous with acid house, and it was during this period that MDMA gained prominence as a party drug.

Serotonin

5-HTserotonergic5-hydroxytryptamine
MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine, and noradrenaline in parts of the brain.
The empathogen-entactogen MDMA releases serotonin from synaptic vesicles of neurons.

Euphoria

euphoriceuphorianthigh
Euphoria – a sense of general well-being and happiness
Dopaminergic stimulants like amphetamine, methamphetamine, cocaine, MDMA, and methylphenidate are euphoriants.

Serotonin syndrome

hyperserotonemiaserotonin toxicitycentral toxic serotonin reaction
Acute toxicity is mainly caused by serotonin syndrome and sympathomimetic effects.
This may include selective serotonin reuptake inhibitor (SSRI), serotonin norepinephrine reuptake inhibitor (SNRI), monoamine oxidase inhibitor (MAOI), tricyclic antidepressants (TCAs), amphetamines, pethidine (meperidine), tramadol, dextromethorphan, buspirone, L-tryptophan, 5-HTP, St. John's wort, triptans, ecstasy (MDMA), metoclopramide, ondansetron, or cocaine.

Substance dependence

addictiondependencedrug dependence
One study found approximately 15% of chronic MDMA users met the DSM-IV diagnostic criteria for substance dependence.

3,4-Methylenedioxy-N-ethylamphetamine

MDEAmethylenedioxyethylamphetamineMDE
Tablets sold as ecstasy sometimes contain 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxyethylamphetamine (MDEA), other amphetamine derivatives, caffeine, opiates, or painkillers.
MDEA is used recreationally in a similar manner to MDMA (also called ecstasy), however the subjective effects of MDEA are milder and shorter lasting.

Hyperthermia

heat stressheat strokehyperthermic
The most serious short-term physical health risks of MDMA are hyperthermia and dehydration.
Various stimulant drugs, including amphetamines and cocaine, and hallucinogenic drugs, including PCP, LSD, and MDMA can produce hyperthermia as an adverse effect.

Hallucinogen

hallucinogenicpsychedelic drughallucinogens
It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.
Despite being scheduled as a controlled substance in the mid-1980s, MDMA's popularity has been growing since that time in western Europe and in the United States.

Dopamine

DAdopaminergic systemdopaminergic
MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine, and noradrenaline in parts of the brain.
Cocaine, substituted amphetamines (including methamphetamine), Adderall, methylphenidate (marketed as Ritalin or Concerta), MDMA (ecstasy) and other psychostimulants exert their effects primarily or partly by increasing dopamine levels in the brain by a variety of mechanisms.

Neurotransmitter

neurotransmittersexcitatory neurotransmitterneurotransmitter system
MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine, and noradrenaline in parts of the brain.

Monoamine oxidase inhibitor

monoamine oxidase inhibitorsMAOIMAOIs
Severe overdose resulting in death has also been reported in people who took MDMA in combination with certain monoamine oxidase inhibitors, such as phenelzine (Nardil), tranylcypromine (Parnate), or moclobemide (Aurorix, Manerix).
Certain combinations can cause lethal reactions, common examples including SSRIs, tricyclics, MDMA, meperidine, tramadol, and dextromethorphan.

Stimulant psychosis

amphetamine psychosispsychosisdrug-induced psychosis
Common amphetamines include dextroamphetamine, cathinone, DOM, ephedrine, MDMA, methamphetamine, and methcathinone though a large number of such compounds have been synthesized.

Monoamine transporter

MATmonoamine reuptake transporterreuptake transporter
MDMA is also a monoamine transporter substrate (i.e., a substrate for DAT, NET, and SERT), so it enters monoamine neurons via these neuronal membrane transport proteins; by acting as a monoamine transporter substrate, MDMA produces competitive reuptake inhibition at the neuronal membrane transporters (i.e., it competes with endogenous monoamines for reuptake).
Furthermore, drugs such as MDMA ("ecstasy", "molly") and natural alkaloids such as cocaine exert their effects in part by their interaction with MATs, by blocking the transporters from mopping up dopamine, serotonin, and other neurotransmitters from the synapse.

3,4-Methylenedioxyamphetamine

MDAtenamfetaminemethylenedioxyamphetamine
Tablets sold as ecstasy sometimes contain 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxyethylamphetamine (MDEA), other amphetamine derivatives, caffeine, opiates, or painkillers.
MDA is rarely sought after as a recreational drug compared to other drugs in the amphetamine family, however it remains an important and widely used drug due to it being a primary metabolite, the product of hepatic N-dealkylation, of MDMA (ecstasy), In addition, it is not uncommon to find MDA as an adulterant of illicitly produced MDMA.