MT-TN

Mitochondrially encoded tRNA asparagine also known as MT-TN is a transfer RNA which in humans is encoded by the mitochondrial MT-TN gene.wikipedia
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Mitochondrial DNA

mtDNAmitochondrialmitochondrial genome
The MT-TN gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 73 base pairs.

Gene

genesnumber of genesgene sequence
Mitochondrially encoded tRNA asparagine also known as MT-TN is a transfer RNA which in humans is encoded by the mitochondrial MT-TN gene.

Locus (genetics)

locuslociq arm
The MT-TN gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 73 base pairs.

Transfer RNA

tRNAanticodontRNAs
Mitochondrially encoded tRNA asparagine also known as MT-TN is a transfer RNA which in humans is encoded by the mitochondrial MT-TN gene. The structure of a tRNA molecule is a distinctive folded structure which contains three hairpin loops and resembles a three-leafed clover.

Clover

Trifoliumcloversalsike
The structure of a tRNA molecule is a distinctive folded structure which contains three hairpin loops and resembles a three-leafed clover.

RNA

ribonucleic aciddsRNAdouble-stranded RNA
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Asparagine

AsnL-asparagineasparagin
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Peptide

polypeptidepeptidespolypeptides
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Ribosome

ribosomesribosomal70S
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Protein

proteinsproteinaceousstructural proteins
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Translation (biology)

translationtranslatedprotein translation
MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Ophthalmoparesis

ophthalmoplegiadifficulty moving the eyesextraocular muscle paresis
Mutations in MT-TN have been associated with isolated ophthalmoplegia.

Hearing loss

deafdeafnesshearing impairment
Common symptoms of the disorder include hearing loss, loss of sensation in the limbs, ataxia, and neuropathy.

Ataxia

gluten ataxiaataxicloss of coordination
Common symptoms of the disorder include hearing loss, loss of sensation in the limbs, ataxia, and neuropathy.

Peripheral neuropathy

neuropathyneuropathiesneuropathic
Common symptoms of the disorder include hearing loss, loss of sensation in the limbs, ataxia, and neuropathy.

Mitochondrion

mitochondriamitochondrialmitochondrial membrane
Mitochondrially encoded tRNA asparagine also known as MT-TN is a transfer RNA which in humans is encoded by the mitochondrial MT-TN gene.

Failure to thrive

growth failurepoor growthfailed to thrive
In addition, a 5728A>G transition of MT-TN was found to result in a combined deficiency of complex I and IV, with symptoms of failure to thrive, renal failure, and mental retardation.

Kidney failure

renal failurekidney problemsrenal impairment
In addition, a 5728A>G transition of MT-TN was found to result in a combined deficiency of complex I and IV, with symptoms of failure to thrive, renal failure, and mental retardation.

Intellectual disability

mental retardationintellectually disabledintellectual disabilities
In addition, a 5728A>G transition of MT-TN was found to result in a combined deficiency of complex I and IV, with symptoms of failure to thrive, renal failure, and mental retardation.

Electron transport chain

respiratory chainelectron transportmitochondrial respiratory chain
MT-TN mutations have been associated with complex IV deficiency of the mitochondrial respiratory chain, also known as the cytochrome c oxidase deficiency.

Cytochrome c oxidase

cytochrome oxidaseComplex IVCOI
MT-TN mutations have been associated with complex IV deficiency of the mitochondrial respiratory chain, also known as the cytochrome c oxidase deficiency.

Skeletal muscle

skeletal musclesskeletalmuscle
Cytochrome c oxidase deficiency is a rare genetic condition that can affect multiple parts of the body, including skeletal muscles, the heart, the brain, or the liver.

Heart

cardiachuman heartapex of the heart
Cytochrome c oxidase deficiency is a rare genetic condition that can affect multiple parts of the body, including skeletal muscles, the heart, the brain, or the liver.

Brain

brain functionmammalian braincerebral
Cytochrome c oxidase deficiency is a rare genetic condition that can affect multiple parts of the body, including skeletal muscles, the heart, the brain, or the liver.

Liver

hepaticliver protein synthesislivers
Cytochrome c oxidase deficiency is a rare genetic condition that can affect multiple parts of the body, including skeletal muscles, the heart, the brain, or the liver.