A report on Malaria and Splenomegaly

Malaria parasite connecting to a red blood cell
CT scan in a patient with chronic lymphocytic leukemia, showing splenomegaly. Yellow arrows point at the spleen.
Main symptoms of malaria
Maximum dimension of the spleen on abdominal ultrasonography.
The life cycle of malaria parasites. Sporozoites are introduced by a mosquito bite. They migrate to the liver, where they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Normal spleen (in green)
Micrograph of a placenta from a stillbirth due to maternal malaria. H&E stain. Red blood cells are anuclear; blue/black staining in bright red structures (red blood cells) indicate foreign nuclei from the parasites.
Electron micrograph of a Plasmodium falciparum-infected red blood cell (center), illustrating adhesion protein "knobs"
The blood film is the gold standard for malaria diagnosis.
Ring-forms and gametocytes of Plasmodium falciparum in human blood
An Anopheles stephensi mosquito shortly after obtaining blood from a human (the droplet of blood is expelled as a surplus). This mosquito is a vector of malaria, and mosquito control is an effective way of reducing its incidence.
Man spraying kerosene oil in standing water, Panama Canal Zone, 1912
Walls where indoor residual spraying of DDT has been applied. The mosquitoes remain on the wall until they fall down dead on the floor.
A mosquito net in use.
An advertisement for quinine as a malaria treatment from 1927.
Deaths due to malaria per million persons in 2012
Past and current malaria prevalence in 2009
Ancient malaria oocysts preserved in Dominican amber
British doctor Ronald Ross received the Nobel Prize for Physiology or Medicine in 1902 for his work on malaria.
Chinese medical researcher Tu Youyou received the Nobel Prize for Physiology or Medicine in 2015 for her work on the antimalarial drug artemisinin.
Artemisia annua, source of the antimalarial drug artemisinin
U.S. Marines with malaria in a field hospital on Guadalcanal, October 1942
Members of the Malaria Commission of the League of Nations collecting larvae on the Danube delta, 1929
1962 Pakistani postage stamp promoting malaria eradication program
Malaria clinic in Tanzania
Child with malaria in Ethiopia
World War II poster
Disability-adjusted life year for malaria per 100,000 inhabitants in 2004 no data <10 0–100 100–500 500–1000 1000–1500 1500–2000 2000–2500 2500–2750 2750–3000 3000–3250 3250–3500 ≥3500

malaria

- Splenomegaly

An enlarged spleen, enlarged liver or both of these, severe headache, low blood sugar, and haemoglobin in the urine with kidney failure may occur.

- Malaria
Malaria parasite connecting to a red blood cell

2 related topics with Alpha

Overall
Figure shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin.

Hemolytic anemia

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Form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular).

Form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular).

Figure shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin.

In addition, symptoms related to hemolysis may be present such as chills, jaundice, dark urine, and an enlarged spleen.

Acquired hemolytic anemia is also encountered in burns and as a result of certain infections (e.g. malaria).

The human spleen is located in the upper left abdomen, behind the stomach

Spleen

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Organ found in all vertebrates.

Organ found in all vertebrates.

The human spleen is located in the upper left abdomen, behind the stomach
A 3D medical animation still of spleen structure & exact location
Visceral surface of the spleen
Micrograph of splenic tissue showing the red pulp (red), white pulp (blue) and a thickened inflamed capusule (mostly pink – top of image). H&E stain.
The spleen contains two different tissues, white pulp (A) and red pulp (B). The white pulp functions in producing and growing immune and blood cells. The red pulp functions in filtering blood of antigens, microorganisms, and defective or worn-out red blood cells.
Thalassemia enlarged spleen taken after splenectomy
Laparoscopic view of a horse's spleen (the purple and grey mottled organ)
Spleen seen on abdominal ultrasonography
Maximum length of spleen on abdominal ultrasonography
Back of lumbar region, showing surface markings for kidneys, ureters, and spleen
Side of thorax, showing surface markings for bones, lungs (purple), pleura (blue), and spleen (green)
Transverse section of the spleen, showing the trabecular tissue and the splenic vein and its tributaries
Spleen
Laparoscopic view of human spleen

Enlargement of the spleen is known as splenomegaly.

It may be caused by sickle cell anemia, sarcoidosis, malaria, bacterial endocarditis, leukemia, polycythemia vera, pernicious anemia, Gaucher's disease, leishmaniasis, Hodgkin's disease, Banti's disease, hereditary spherocytosis, cysts, glandular fever (mononucleosis or 'Mono' caused by the Epstein–Barr virus, infection from cytomegalovirus), and tumours.