Marfan syndrome

Marfan's syndromeMarfanMarfanoidMarfans SyndromeGhent criteriaMarfan syndrome type IIMarfanoid Habitus
Marfan syndrome (MFS) is a genetic disorder of the connective tissue.wikipedia
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Heart

cardiachuman heartapex of the heart
The most serious complications involve the heart and aorta, with an increased risk of mitral valve prolapse and aortic aneurysm.

Propranolol

propanololInderalDexpropranolol
Management often includes the use of beta blockers such as propranolol or atenolol or, if that is not tolerated, calcium channel blockers or ACE inhibitors.

Atenolol

EsatenololTenorminAtehexal
Management often includes the use of beta blockers such as propranolol or atenolol or, if that is not tolerated, calcium channel blockers or ACE inhibitors.

Calcium channel blocker

calcium channel blockerscalcium-channel blockerscalcium antagonist
Management often includes the use of beta blockers such as propranolol or atenolol or, if that is not tolerated, calcium channel blockers or ACE inhibitors.

ACE inhibitor

ACE inhibitorsangiotensin converting enzyme inhibitorangiotensin-converting enzyme inhibitor
Management often includes the use of beta blockers such as propranolol or atenolol or, if that is not tolerated, calcium channel blockers or ACE inhibitors.

Heart valve

heart valvesvalvesatrioventricular valves
Surgery may be required to repair the aorta or replace a heart valve.

Pediatrics

pediatricianpediatricpaediatrics
It is named after Antoine Marfan, a French pediatrician who first described the condition in 1896.

Medical sign

signsclinical signsign
More than 30 different signs and symptoms are variably associated with Marfan syndrome.

Symptom

symptomsnon-specific symptomssymptomatic
More than 30 different signs and symptoms are variably associated with Marfan syndrome.

Human skeleton

skeletonskeletalskeletons
Most of the readily visible signs are associated with the skeletal system.

Lordosis

lumbar hyperlordosislordoticlumbar lordosis
Besides affecting height and limb proportions, people with Marfan syndrome may have abnormal lateral curvature of the spine (scoliosis), thoracic lordosis, abnormal indentation (pectus excavatum) or protrusion (pectus carinatum) of the sternum, abnormal joint flexibility, a high-arched palate with crowded teeth and an overbite, flat feet, hammer toes, stooped shoulders, and unexplained stretch marks on the skin.

Sternum

manubriumbreastbonesternal
Besides affecting height and limb proportions, people with Marfan syndrome may have abnormal lateral curvature of the spine (scoliosis), thoracic lordosis, abnormal indentation (pectus excavatum) or protrusion (pectus carinatum) of the sternum, abnormal joint flexibility, a high-arched palate with crowded teeth and an overbite, flat feet, hammer toes, stooped shoulders, and unexplained stretch marks on the skin.

Hammer toe

claw toeshammertoehammertoes
Besides affecting height and limb proportions, people with Marfan syndrome may have abnormal lateral curvature of the spine (scoliosis), thoracic lordosis, abnormal indentation (pectus excavatum) or protrusion (pectus carinatum) of the sternum, abnormal joint flexibility, a high-arched palate with crowded teeth and an overbite, flat feet, hammer toes, stooped shoulders, and unexplained stretch marks on the skin.

Speech disorder

speech impedimentmutespeech disorders
Some people with Marfan have speech disorders resulting from symptomatic high palates and small jaws.

Femoral head

head of the femurfemur headfovea
Other signs include limited range of motion in the hips due to the femoral head protruding into abnormally deep hip sockets.

Near-sightedness

myopiamyopicnearsightedness
Nearsightedness and blurred vision are common, but farsightedness can also result particularly if the lens is highly subluxated.

Astigmatism

against the rule astigmatismastigmaticastigmatic myopic
Nearsightedness and blurred vision are common, but farsightedness can also result particularly if the lens is highly subluxated.

Lens (anatomy)

lenscrystalline lenslenses
Subluxation (partial dislocation) of the lens can be detected clinically in 80% of people with Marfan syndrome by the use of a slit-lamp biomicroscope.

Slit lamp

slit-lampslit-lamp examinationSlit lamp examination
Subluxation (partial dislocation) of the lens can be detected clinically in 80% of people with Marfan syndrome by the use of a slit-lamp biomicroscope.

Strabismus

squintcross-eyedheterotropia
Other signs and symptoms affecting the eye include increased length along an axis of the globe, myopia, corneal flatness, strabismus, exotropia, and esotropia.

Exotropia

divergent strabismusexotropesExotropic
Other signs and symptoms affecting the eye include increased length along an axis of the globe, myopia, corneal flatness, strabismus, exotropia, and esotropia.

Esotropia

cross-eyedaccommodative esotropiaAlternating esotropia
Other signs and symptoms affecting the eye include increased length along an axis of the globe, myopia, corneal flatness, strabismus, exotropia, and esotropia.

Circulatory system

cardiovascularcirculationcardiovascular system
The most serious signs and symptoms associated with Marfan syndrome involve the cardiovascular system: undue fatigue, shortness of breath, heart palpitations, racing heartbeats, or chest pain radiating to the back, shoulder, or arm.

Fatigue

exhaustionOverexertiontiredness
The most serious signs and symptoms associated with Marfan syndrome involve the cardiovascular system: undue fatigue, shortness of breath, heart palpitations, racing heartbeats, or chest pain radiating to the back, shoulder, or arm.

Shortness of breath

dyspnearespiratory distressdyspnoea
The most serious signs and symptoms associated with Marfan syndrome involve the cardiovascular system: undue fatigue, shortness of breath, heart palpitations, racing heartbeats, or chest pain radiating to the back, shoulder, or arm.