A report on Mefloquine

Mefloquine (Lariam) 250mg tablets

Medication used to prevent or treat malaria.

- Mefloquine

9 related topics with Alpha

Overall

Chloroquine

4 links

Medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.

Medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.

Medical quinolines
Hemozoin formation in P. falciparum: many antimalarials are strong inhibitors of hemozoin crystal growth.
Resochin tablet package

In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

Antimalarial medication

4 links

Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.

Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.

It is especially useful in areas where there is known to be a high level of resistance to chloroquine, mefloquine, and sulfa drug combinations with pyrimethamine.

Malaria parasite connecting to a red blood cell

Malaria

3 links

Mosquito-borne infectious disease that affects humans and other animals.

Mosquito-borne infectious disease that affects humans and other animals.

Malaria parasite connecting to a red blood cell
Main symptoms of malaria
The life cycle of malaria parasites. Sporozoites are introduced by a mosquito bite. They migrate to the liver, where they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Micrograph of a placenta from a stillbirth due to maternal malaria. H&E stain. Red blood cells are anuclear; blue/black staining in bright red structures (red blood cells) indicate foreign nuclei from the parasites.
Electron micrograph of a Plasmodium falciparum-infected red blood cell (center), illustrating adhesion protein "knobs"
The blood film is the gold standard for malaria diagnosis.
Ring-forms and gametocytes of Plasmodium falciparum in human blood
An Anopheles stephensi mosquito shortly after obtaining blood from a human (the droplet of blood is expelled as a surplus). This mosquito is a vector of malaria, and mosquito control is an effective way of reducing its incidence.
Man spraying kerosene oil in standing water, Panama Canal Zone, 1912
Walls where indoor residual spraying of DDT has been applied. The mosquitoes remain on the wall until they fall down dead on the floor.
A mosquito net in use.
An advertisement for quinine as a malaria treatment from 1927.
Deaths due to malaria per million persons in 2012
Past and current malaria prevalence in 2009
Ancient malaria oocysts preserved in Dominican amber
British doctor Ronald Ross received the Nobel Prize for Physiology or Medicine in 1902 for his work on malaria.
Chinese medical researcher Tu Youyou received the Nobel Prize for Physiology or Medicine in 2015 for her work on the antimalarial drug artemisinin.
Artemisia annua, source of the antimalarial drug artemisinin
U.S. Marines with malaria in a field hospital on Guadalcanal, October 1942
Members of the Malaria Commission of the League of Nations collecting larvae on the Danube delta, 1929
1962 Pakistani postage stamp promoting malaria eradication program
Malaria clinic in Tanzania
Child with malaria in Ethiopia
World War II poster
Disability-adjusted life year for malaria per 100,000 inhabitants in 2004
no data
<10
0–100
100–500
500–1000
1000–1500
1500–2000
2000–2500
2500–2750
2750–3000
3000–3250
3250–3500
≥3500

The second medication may be either mefloquine, lumefantrine, or sulfadoxine/pyrimethamine.

Plasmodium vivax

3 links

Protozoal parasite and a human pathogen.

Protozoal parasite and a human pathogen.

Mefloquine is a good alternative and in some countries is more readily available.

2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.

WHO Model List of Essential Medicines

1 links

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML ), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML ), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.
A skeletal model of the chemical structure of aspirin
A skeletal model of the chemical structure of albendazole
Pure crystals of ethambutol
Two capsules of atazanavir
Bag containing one unit of fresh frozen plasma
A vial of oral cholera vaccine

Artesunate/mefloquine (artesunate + mefloquine)

Halofantrine

1 links

Drug used to treat malaria.

Drug used to treat malaria.

The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with mefloquine.

Roche

0 links

Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

Participation certificate of the F. Hoffmann-LaRoche & Co AG, issued 15 January 1932
Tamiflu box

Lariam (mefloquine), for malaria (both prevention and treatment).

Boxed warning

0 links

Type of warning that appears on the package insert for certain prescription drugs, so called because

Type of warning that appears on the package insert for certain prescription drugs, so called because

In July 2013, the FDA issued a boxed warning for the antimalarial drug mefloquine, noting the drug's adverse neuropsychiatric side effects, and emphasizing neurological effects from the drug could "occur at any time during drug use, and can last for months to years after the drug is stopped or can be permanent".

T2-weighted MRI showing progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy

0 links

Rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal).

Rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal).

T2-weighted MRI showing progressive multifocal leukoencephalopathy

In June 2010, the first case report appeared of a PML patient being successfully treated with the antimalarial drug mefloquine with activity against the JC virus.