A report on Plasmodium vivax and Mefloquine

Mefloquine (Lariam) 250mg tablets

Mefloquine is used as a treatment for chloroquine-sensitive or resistant Plasmodium falciparum malaria, and is deemed a reasonable alternative for uncomplicated chloroquine-resistant Plasmodium vivax malaria.

- Mefloquine

Mefloquine is a good alternative and in some countries is more readily available.

- Plasmodium vivax

3 related topics with Alpha

Overall
Malaria parasite connecting to a red blood cell

Malaria

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Mosquito-borne infectious disease that affects humans and other animals.

Mosquito-borne infectious disease that affects humans and other animals.

Malaria parasite connecting to a red blood cell
Main symptoms of malaria
The life cycle of malaria parasites. Sporozoites are introduced by a mosquito bite. They migrate to the liver, where they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Micrograph of a placenta from a stillbirth due to maternal malaria. H&E stain. Red blood cells are anuclear; blue/black staining in bright red structures (red blood cells) indicate foreign nuclei from the parasites.
Electron micrograph of a Plasmodium falciparum-infected red blood cell (center), illustrating adhesion protein "knobs"
The blood film is the gold standard for malaria diagnosis.
Ring-forms and gametocytes of Plasmodium falciparum in human blood
An Anopheles stephensi mosquito shortly after obtaining blood from a human (the droplet of blood is expelled as a surplus). This mosquito is a vector of malaria, and mosquito control is an effective way of reducing its incidence.
Man spraying kerosene oil in standing water, Panama Canal Zone, 1912
Walls where indoor residual spraying of DDT has been applied. The mosquitoes remain on the wall until they fall down dead on the floor.
A mosquito net in use.
An advertisement for quinine as a malaria treatment from 1927.
Deaths due to malaria per million persons in 2012
Past and current malaria prevalence in 2009
Ancient malaria oocysts preserved in Dominican amber
British doctor Ronald Ross received the Nobel Prize for Physiology or Medicine in 1902 for his work on malaria.
Chinese medical researcher Tu Youyou received the Nobel Prize for Physiology or Medicine in 2015 for her work on the antimalarial drug artemisinin.
Artemisia annua, source of the antimalarial drug artemisinin
U.S. Marines with malaria in a field hospital on Guadalcanal, October 1942
Members of the Malaria Commission of the League of Nations collecting larvae on the Danube delta, 1929
1962 Pakistani postage stamp promoting malaria eradication program
Malaria clinic in Tanzania
Child with malaria in Ethiopia
World War II poster
Disability-adjusted life year for malaria per 100,000 inhabitants in 2004 no data <10 0–100 100–500 500–1000 1000–1500 1500–2000 2000–2500 2500–2750 2750–3000 3000–3250 3250–3500 ≥3500

Most deaths are caused by P. falciparum, whereas P. vivax, P. ovale, and P. malariae generally cause a milder form of malaria.

The second medication may be either mefloquine, lumefantrine, or sulfadoxine/pyrimethamine.

Chloroquine

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Medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.

Medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.

Medical quinolines
Hemozoin formation in P. falciparum: many antimalarials are strong inhibitors of hemozoin crystal growth.
Resochin tablet package

]]Chloroquine has been used in the treatment and prevention of malaria from Plasmodium vivax, ''[[Plasmodium ovale|P.

In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

Antimalarial medication

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Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.

Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.

Quinine is an alkaloid that acts as a blood schizonticidal and weak gametocide against Plasmodium vivax and Plasmodium malariae.

It is especially useful in areas where there is known to be a high level of resistance to chloroquine, mefloquine, and sulfa drug combinations with pyrimethamine.