Megavitamin therapy

A bottle of B-complex vitamin pills

Use of large doses of vitamins, often many times greater than the recommended dietary allowance in the attempt to prevent or treat diseases.

- Megavitamin therapy
A bottle of B-complex vitamin pills

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Linus Pauling in 1962

Linus Pauling

American chemist, biochemist, chemical engineer, peace activist, author, and educator.

American chemist, biochemist, chemical engineer, peace activist, author, and educator.

Linus Pauling in 1962
Herman Henry William Pauling, Linus Pauling's father, c. 1900
Pauling's graduation photo from Oregon State University, 1922
Linus Pauling with an inset of his Nobel Prize in 1955
Pauling in 1941
An alpha helix in ultra-high-resolution electron density contours, with O atoms in red, N atoms in blue, and hydrogen bonds as green dotted lines (PDB file 2NRL, 17–32).
Pauling in 1948
Beckman D2 Oxygen Analyzer, ca.1950
Beckman Model 735 Dissolved O2 Analyzer, later model based on Pauling's design, 1968
Beckman Model D Oxygen Meter, based on Pauling's design, with infant incubator, 1959
Denial letter from Ruth B. Shipley, Chief Passport Division, Department of State to Linus Pauling on February 14, 1952
Pauling's beret on display at the Nobel Prize Museum
Pauling's book, How to Live Longer and Feel Better, advocated very high intake of Vitamin C.
The Pauling children at a gathering in celebration of the 1954 Nobel Prizes in Stockholm, Sweden. Seated from left: Linus Pauling, Jr., Peter Pauling and Linda Pauling. Standing from left: an unidentified person, and Crellin Pauling

In his later years he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy, and dietary supplements.

Marcia Angell: "There cannot be two kinds of medicine – conventional and alternative".

Orthomolecular medicine

Form of alternative medicine that aims to maintain human health through nutritional supplementation.

Form of alternative medicine that aims to maintain human health through nutritional supplementation.

Marcia Angell: "There cannot be two kinds of medicine – conventional and alternative".

The approach is sometimes referred to as megavitamin therapy, because its practice evolved out of, and in some cases still uses, doses of vitamins and minerals many times higher than the recommended dietary intake.

Abram Hoffer

Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders.

Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders.

According to Hoffer, megavitamin therapy and other nutritional interventions are potentially effective treatments for cancer and schizophrenia.

Chemical structure of vitamin C

Vitamin C megadosage

Term describing the consumption or injection of vitamin C in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day.

Term describing the consumption or injection of vitamin C in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day.

Chemical structure of vitamin C
3D molecular model of vitamin C
Linus Pauling's popular and influential 1986 book How to Live Longer and Feel Better advocated very high doses of vitamin C

Orthomolecular-based megadose recommendations for vitamin C are based mainly on theoretical speculation and observational studies, such as those published by Fred R. Klenner from the 1940s through the 1970s.

Staphylococcus aureus (AB Test)

Claus W. Jungeblut

American bacteriologist and vitamin researcher.

American bacteriologist and vitamin researcher.

Staphylococcus aureus (AB Test)

In the 1930s, Jungeblut conducted some of the first experiments on vitamin C therapy (megavitamin therapy).

List of people in alternative medicine

List of people in alternative medicine who are notable for developing, founding, inventing, promoting, practicing, marketing, commentating or researching on alternative medicine.

List of people in alternative medicine who are notable for developing, founding, inventing, promoting, practicing, marketing, commentating or researching on alternative medicine.

Linus Pauling – Coined the term "orthomolecular medicine," the controversial use of Vitamin C and other megavitamin therapies. Pauling was however not a general supporter of alternative medicine.

The prevalence of mental illness is higher in more economically unequal countries

Orthomolecular psychiatry

Use of orthomolecular medicine for mental illness.

Use of orthomolecular medicine for mental illness.

The prevalence of mental illness is higher in more economically unequal countries

Diagnostic measures and therapies commonly employed include "individual biochemical workup", fasting, identifying suggested allergies, dietary changes, megavitamin therapy, amino acids, and other so-called "pharmacologic nutrients".

Chronology of the universe as deduced by the prevailing Big Bang theory, a result from science and obtained knowledge

List of topics characterized as pseudoscience

List of topics that have, either currently or in the past, been characterized as pseudoscience by academics or researchers.

List of topics that have, either currently or in the past, been characterized as pseudoscience by academics or researchers.

Chronology of the universe as deduced by the prevailing Big Bang theory, a result from science and obtained knowledge

Orthomolecular medicine, sometimes referred to as megavitamin therapy, is a form of alternative medicine that aims to maintain human health through nutritional supplementation. The concept builds on the idea of an optimum nutritional environment in the body and suggests that diseases reflect deficiencies in this environment. Treatment for disease, according to this view, involves attempts to correct "imbalances or deficiencies based on individual biochemistry" by use of substances such as vitamins, minerals, amino acids, trace elements and fatty acids. The notions behind orthomolecular medicine are not supported by sound medical evidence and the therapy is not effective; even the validity of calling the orthomolecular approach a form of medicine has been questioned since the 1970s.

Saint Francis University

Private Catholic university in Loretto, Pennsylvania.

Private Catholic university in Loretto, Pennsylvania.

Fred R. Klenner (1907–1984) – author and medical researcher; received both BS and MS in biology from Saint Francis University.

Supplements of calcium and vitamin D

Hypervitaminosis

Condition of abnormally high storage levels of vitamins, which can lead to various symptoms as over excitement, irritability, or even toxicity.

Condition of abnormally high storage levels of vitamins, which can lead to various symptoms as over excitement, irritability, or even toxicity.

Supplements of calcium and vitamin D

Generally, toxic levels of vitamins stem from high supplement intake and not always from natural sources but rather the mix of natural, derived vitamins and enhancers (vitamin boosters).