Meibomian gland

meibomian glandstarsal glandsmeibomian gland dysfunctionmeibomianmeibumtarsal glandwaterline
Meibomian glands (often written with a small "m" and also called tarsal glands) are holocrine type exocrine glands, along the rims of the eyelid inside the tarsal plate.wikipedia
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Eyelid

eyelidspalpebralpalpebra
Meibomian glands (often written with a small "m" and also called tarsal glands) are holocrine type exocrine glands, along the rims of the eyelid inside the tarsal plate.
The meibomian glands lie within the eyelid and secrete the lipid part of the tear film.

Blepharitis

blephartiseyelidsgranulation of the eyelids
They may also contribute to blepharitis.
The overall etiology is a result of bacteria and inflammation from congested meibomian oil glands at the base of each eyelash.

Tears

lacrimationteartear film
They produce meibum, an oily substance that prevents evaporation of the eye's tear film.

Sebaceous gland

sebumsebaceous glandssebaceous
The biochemical composition of meibum is extremely complex and very different from that of sebum.
In the eyelids, meibomian glands, also called tarsal glands, are a type of sebaceous gland that secrete a special type of sebum into tears.

Holocrine

holocrine glandsholocrine process
Meibomian glands (often written with a small "m" and also called tarsal glands) are holocrine type exocrine glands, along the rims of the eyelid inside the tarsal plate.
Examples of holocrine glands include the sebaceous glands of the skin and the meibomian glands of the eyelid.

Dry eye syndrome

keratoconjunctivitis siccadry eyedry eyes
Dysfunctional meibomian glands often cause dry eyes, one of the more common eye conditions.
This can result from contact lens use, meibomian gland dysfunction, allergies, pregnancy, Sjögren syndrome, vitamin A deficiency, LASIK surgery, and certain medications such as antihistamines, some blood pressure medication, hormone replacement therapy, and antidepressants.

Exocrine gland

exocrineexocrine glandssecretory gland
Meibomian glands (often written with a small "m" and also called tarsal glands) are holocrine type exocrine glands, along the rims of the eyelid inside the tarsal plate.

Tarsus (eyelids)

tarsal plateSuperior tarsustarsi
Meibomian glands (often written with a small "m" and also called tarsal glands) are holocrine type exocrine glands, along the rims of the eyelid inside the tarsal plate.
Along the inner margin of the tarsus are modified sebaceous glands known as tarsal glands (or meibomian glands), aligned vertically within the tarsi: 30 to 40 glands in the upper lid, and 20 to 30 in the lower lid, which secrete a lipid-rich product which helps keep the lacrimal secretions or tears from evaporating too quickly, thus keeping the eye moist.

Heinrich Meibom (doctor)

Heinrich MeibomIoannes Henricus MeibomiusHeinrich Meibome
The glands are named after Heinrich Meibom (1638–1700), a German physician.
He is known for his discovery of the sebaceous glands in the eyelid that are named after him, the Meibomian glands.

Thygeson's superficial punctate keratopathy

keratopathypunctate epithelial keratopathypunctate keratopathy
Besides leading to dry eyes, the obstructions can be degraded by bacterial lipases, resulting in the formation of free fatty acids, which irritate the eyes and sometimes cause punctate keratopathy.
However, there seem to be indications that dysfunctioning of the Meibomian gland can cause the condition.

Intense pulsed light

IPLblood vessel removalIntense pulse light
Intense pulsed light (IPL) treatments have also been shown to reduce inflammation and improve the gland function in patients.
IPL is increasingly used in optometry and ophthalmology as well, to treat evaporative dry eye disease due to meibomian gland dysfunction.

Lifitegrast

Lifitegrast and Restasis are topical medication commonly used to control the inflammation and improve the oil quality.
It is often used in conjunction with ciclosporin (Ikervis or Restasis) for dry eye treatment including meibomian gland dysfunction and inflammatory dry eye.

Ciclosporin

cyclosporinecyclosporincyclosporin A
Lifitegrast and Restasis are topical medication commonly used to control the inflammation and improve the oil quality.
It is also approved in the US for treating of rheumatoid arthritis and psoriasis, persistent nummular keratitis following adenoviral keratoconjunctivitis, and as eye drops for treating dry eyes caused by Sjögren's syndrome and meibomian gland dysfunction.

Chalazion

ChalaziaChalazion cysteyelid cysts
The blocked gland is usually the meibomian gland but can also be the gland of Zeis.

List of glands of the human body

List of specialized glands within the human integumentary system

Isotretinoin

Accutane13-cis retinoic acidRoaccutane
Meibomian gland dysfunction may be caused by some prescription medications, notably isotretinoin.
Isotretinoin is known to cause meibomian gland dysfunction which causes persistent keratoconjunctivitis sicca (dry eye).

Human eye

eyeeyeseyeball
They produce meibum, an oily substance that prevents evaporation of the eye's tear film.

Lipid

lipidsglycerolipidfat
Lipids are the major components of meibum (also known as "meibomian gland secretions").

Mass spectrometry

mass spectrometerMSmass spectrometric
Currently, the most sensitive and informative approach to lipidomic analysis of meibum is mass spectrometry either with direct infusion or in combination with liquid chromatography.

Chromatography

liquid chromatographychromatographicstationary phase
Currently, the most sensitive and informative approach to lipidomic analysis of meibum is mass spectrometry either with direct infusion or in combination with liquid chromatography.

Lipase

lipaseslipase LIPFE1104
Besides leading to dry eyes, the obstructions can be degraded by bacterial lipases, resulting in the formation of free fatty acids, which irritate the eyes and sometimes cause punctate keratopathy.

Fatty acid

fatty acidsfree fatty acidsfree fatty acid
Besides leading to dry eyes, the obstructions can be degraded by bacterial lipases, resulting in the formation of free fatty acids, which irritate the eyes and sometimes cause punctate keratopathy.

Demodex brevis

Factors that contribute to meibomian gland dysfunction can include things such as a person's age and/or hormones or severe infestation of Demodex brevis mite.

Warm compress

warm compresseswarm moist compress
Treatment can include warm compresses or expression of the gland by a professional.

Medication

pharmaceuticalpharmaceuticalspharmaceutical drug
Meibomian gland dysfunction may be caused by some prescription medications, notably isotretinoin.