Membranous glomerulonephritis

membranous nephropathymembranous nephritisglomerulonephritis, membranousMembranous glomerularnephritis
Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 and 50 years, usually Caucasian.wikipedia
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Nephrotic syndrome

a serious kidney disorderGlomerulosclerosisidiopathic nephrotic syndrome
It is the second most common cause of nephrotic syndrome in adults, with focal segmental glomerulosclerosis (FSGS) recently becoming the most common. Some people may present as nephrotic syndrome with proteinuria, edema with or without kidney failure.
Causes include a number of kidney diseases such as focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease.

Proteinuria

protein in the urineproteinIsolated proteinuria
Some people may present as nephrotic syndrome with proteinuria, edema with or without kidney failure. Others may not have symptoms and may be picked up on screening or urinalysis as having high amounts of protein loss in the urine.

Hepatitis B

Bchronic hepatitis Bhepatitis B virus
Hepatitis B virus has been linked to the development of membranous glomerulonephritis (MGN).

Membranoproliferative glomerulonephritis

mesangiocapillary glomerulonephritisdense deposit diseaseMPGN
By contrast, membranoproliferative glomerulonephritis has a similar name, but is considered a separate condition with a distinctly different causality.
It should not be confused with membranous glomerulonephritis, a condition in which the basement membrane is thickened, but the mesangium is not.

Jones' stain

The Jones stain demonstrates the spiked GBM, caused by subepithelial deposits, seen in membranous nephropathy.

Glomerulonephritis

C3 glomerulonephritisglomerular nephritisglomerulonephritis, membranoproliferative
Membranoproliferative glomerulonephritis involves the basement membrane and mesangium, while membranous glomerulonephritis involves the basement membrane but not the mesangium.
Membranous glomerulonephritis may cause either nephrotic or a nephritic picture.

Kidney

kidneysrenalkidney disorder
Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 and 50 years, usually Caucasian.

Focal segmental glomerulosclerosis

focal segmental glomerular sclerosisFSGSFocal and segmental glomerular lesions
It is the second most common cause of nephrotic syndrome in adults, with focal segmental glomerulosclerosis (FSGS) recently becoming the most common.

Edema

dropsyoedemaswelling
Some people may present as nephrotic syndrome with proteinuria, edema with or without kidney failure.

Kidney failure

renal failurekidney problemsrenal impairment
Some people may present as nephrotic syndrome with proteinuria, edema with or without kidney failure.

Clinical urine tests

urinalysisurine testurine sample
Others may not have symptoms and may be picked up on screening or urinalysis as having high amounts of protein loss in the urine.

Biopsy

biopsiestissue biopsybiopsied
A definitive diagnosis of membranous nephropathy requires a kidney biopsy.

Idiopathic disease

idiopathiccryptogenicunknown
85% of MGN cases are classified as primary membranous glomerulonephritis—that is to say, the cause of the disease is idiopathic (of unknown origin or cause).

Phospholipase A

One study has identified antibodies to an M-type phospholipase A 2 receptor in 70% (26 of 37) cases evaluated.

Neprilysin

CD10neutral endopeptidasemembrane metallo-endopeptidase
Other studies have implicated neutral endopeptidase and cationic bovine serum albumin as antigens.

Albumin

albuminsalbuminousalbumin protein
Other studies have implicated neutral endopeptidase and cationic bovine serum albumin as antigens.

Infection

infectious diseaseinfectious diseasesinfections

Syphilis

syphilitictertiary syphilissecondary syphilis

HIV

human immunodeficiency virusHIV-positiveHIV positive