Metabotropic receptor

metabotropicMetabotropic receptors
A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.wikipedia
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Metabotropic glutamate receptor

metabotropic glutamate receptorsmGluR 2/3 mGluR
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process.

GABAB receptor

GABA B receptorGABA B GABA B receptors
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.
GABA B receptors (GABA B R) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels.

Muscarinic acetylcholine receptor

muscarinicmuscarinic receptormuscarinic receptors
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.
Muscarinic acetylcholine receptors belong to a class of metabotropic receptors that use G proteins as their signaling mechanism.

Neuropeptide

neuropeptidesneuroactive dipeptideneuroactive peptide
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.
Generally, peptides act at metabotropic or G-protein-coupled receptors expressed by selective populations of neurons.

Dopamine

dopaminergic systemDAdopaminergic
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.
All of them function as metabotropic, G protein-coupled receptors, meaning that they exert their effects via a complex second messenger system.

Neuron

neuronsnerve cellsnerve cell
Metabotropic receptors on the presynaptic membrane can inhibit or, more rarely, facilitate neurotransmitter release from the presynaptic neuron.
Glutamate acts on several types of receptors, and has effects that are excitatory at ionotropic receptors and a modulatory effect at metabotropic receptors.

G protein-coupled receptor

G-protein coupled receptorG protein-coupled receptorsGPCR
Hence, G protein-coupled receptors are inherently metabotropic.
glutamate (metabotropic effect);

Eukaryote

Eukaryotaeukaryoticeukaryotes
A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.

Second messenger system

second messengersecond messengerssecondary messenger
A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.

Receptor (biochemistry)

receptorreceptorscellular receptors
Based on their structural and functional characteristics, the neurotransmitter receptor can be classified into two broad categories: metabotropic and ionotropic receptors.

Signal transduction

signaling pathwayssignaling cascadesignal transduction pathways
In contrast, metabotropic receptors are indirectly linked with ion channels on the plasma membrane of the cell through signal transduction mechanisms, often G proteins.

G protein

G-proteinG proteinsG-proteins
In contrast, metabotropic receptors are indirectly linked with ion channels on the plasma membrane of the cell through signal transduction mechanisms, often G proteins.

Receptor tyrosine kinase

receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptors
Other examples of metabotropic receptors include tyrosine kinases and guanylyl cyclase receptors.

Guanylate cyclase

guanylyl cyclaseguanylate cyclase (GC)NO receptor
Other examples of metabotropic receptors include tyrosine kinases and guanylyl cyclase receptors.

Neurotransmitter

neurotransmittersexcitatory neurotransmitterneurotransmitter system
Based on their structural and functional characteristics, the neurotransmitter receptor can be classified into two broad categories: metabotropic and ionotropic receptors. Metabotropic receptors have neurotransmitters as ligands, which, when bound to the receptors, initiate cascades that can lead to channel-opening or other cellular effects.

Serotonin

5-HTserotonergic5-hydroxytryptamine
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

Norepinephrine

noradrenalinenoradrenergicnoradrenalin
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

Adrenaline

epinephrineadrenaline junkieadrenalin
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

Histamine

histaminesHistaminantihistaminic
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

Cannabinoid

cannabinoidsendocannabinoidendocannabinoids
This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA B receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

N-terminus

N-terminalN terminusN-
The protein's N terminus is located on the extracellular side of the membrane and its C terminus is on the intracellular side.

Ligand (biochemistry)

affinityligandbinding affinity
Metabotropic receptors have neurotransmitters as ligands, which, when bound to the receptors, initiate cascades that can lead to channel-opening or other cellular effects.

Molecule

molecularmoleculesmolecular structure
Since opening channels by metabotropic receptors involves activating a number of molecules in turn, channels associated with these receptors take longer to open than ionotropic receptors do, and they are thus not involved in mechanisms that require quick responses.

Ligand-gated ion channel

ionotropicionotropic receptorligand-gated ion channels
Based on their structural and functional characteristics, the neurotransmitter receptor can be classified into two broad categories: metabotropic and ionotropic receptors. Since opening channels by metabotropic receptors involves activating a number of molecules in turn, channels associated with these receptors take longer to open than ionotropic receptors do, and they are thus not involved in mechanisms that require quick responses.

Potassium channel

potassium channelspotassiumpotassium ion channels
They can make a membrane more excitable by closing K + channels, retaining positive charge within the cell and thus reducing the amount of current necessary to cause an action potential.